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イナムリノン

Inamrinone

Inamrinone lactate

強心薬IV犬猫

別名: Inocor · Amcoral · Vesistol · Wincoram · Amrinone lactate · Win-40680

VetSheet 獣医チームが監修更新日 2026年4月5日エビデンスに基づく獣医学リファレンス

1-3 mg/kg IV as a slow IV bolus followed by a 10-100 micrograms/kg/min IV CRI; ½ the initial bolus may be administered 20-30 minutes after the first bolus.IV· CRI

これは持続点滴（CRI）の速度依存用量です。単純な体重換算ではなく、注入速度を計算してください。

用量は獣医専門家向けの臨床参考資料です。必ず最新の医薬品情報および個別症例に基づいて確認してください。

動物種別用量

🌎 NA — North America🌍 EU — Europe

犬

適応用量経路頻度期間地域
Positive inotropic agent1-3 mg/kg IV as a slow IV bolus followed by a 10-100 micrograms/kg/min IV CRI; ½ the initial bolus may be administered 20-30 minutes after the first bolus.IVCRI—🌎 NA
Positive inotropic agent1-3 mg/kg IV followed by a 30-100 micrograms/kg/min IV CRIIVCRI—🌎 NA
Positive inotropic agent2 mg/kg bolus IV , followed by 30-300 micrograms/kg/min IV infusionIVCRI—🌎 NA
For patients coming off cardiopulmonary bypass with poor cardiac contractility0.25-0.6 mg/kg loading, then 5-45 micrograms/kg/min CRIIVCRI—🌎 NA
Adjunctive treatment for calcium channel blocker overdose30-100 micrograms/kg/min CRI.IVCRI—🌎 NA
  • Adjunctive treatment for calcium channel blocker overdose: Alternative to dopamine or dobutamine; used with fluids, IV calcium, and potentially glucagon.

猫

適応用量経路頻度期間地域
Positive inotropic agent1-3 mg/kg IV followed by 30-100 micro-grams/kg/min IV infusionIVCRI—🌎 NA
Positive inotropic agent1-3 mg/kg IV as a slow IV bolus followed by a 10-100 micrograms/kg/min IV CRI; ½ the initial bolus may be administered 20-30 minutes after the first bolus.IVCRI—🌎 NA

用量は獣医専門家向けの臨床参考資料です。必ず最新の医薬品情報および個別症例に基づいて確認してください。

診察中ですか？VetSheet の AI が薬剤・用量・投与期間を構造化された診察記録に直接記入します。VetSheet の仕組みを見る

概要

イナムリノン（旧名アムリノン）は、​ビピリジン系強心薬​および血管拡張薬です。

  • うっ血性心不全（CHF）の短期管理のための​二次選択薬​です。
  • 非常に高価であり、厳密なモニタリングが必要です。

​臨床のポイント：​ 抗不整脈薬のアミオダロン（amiodarone）との混同による致命的な医療過誤を防ぐため、薬名がアムリノンからイナムリノンに変更されました。

作用機序

Inamrinone acts primarily as a phosphodiesterase III (PDE3) inhibitor.

  • Inhibition of PDE3 → decreased breakdown of intracellular cyclic AMP (cAMP) → increased intracellular calcium in the myocardium → positive inotropy (direct stimulation of cardiac contractility).
  • In vascular smooth muscle, increased cAMP leads to relaxation → vasodilation, which effectively reduces both cardiac preload and afterload.

安全性・警告

禁忌

  • Severe aortic or pulmonic valve disease
  • Hypersensitivity to inamrinone or bisulfites

有害事象

  • Arrhythmias
  • Hypotension
  • Vomiting
  • Diarrhea
  • Thrombocytopenia (particularly with prolonged therapy)
  • Hepatotoxicity
  • Hypersensitivity reactions (variable symptomatology: pericarditis to myositis)

注意事項

Contraindicated in severe aortic or pulmonic valve disease. Use extreme caution in patients with hypertrophic cardiomyopathy. Reproductive safety data are conflicting (FDA Category C); use only when benefits outweigh risks. It is unknown if it is secreted in milk; exercise caution. Must only be used in settings where appropriate cardiovascular monitoring can be employed.

医薬品相互作用

Digoxin

Additive inotropic effect; generally considered a positive drug interaction.

Disopyramide

May cause excessive hypotension when used concurrently.

監視

  • Blood pressure
  • Heart rate/rhythm (continuous ECG recommended)
  • Body weight
  • Platelet counts

薬物動態

吸収

Rapidly absorbed after oral administration, though no oral commercial dosage forms are available. After initial IV injection, effects begin within 2-3 minutes and peak within 10 minutes.

分布

Apparent volume of distribution is 1.2 L/kg (in humans). Exhibits low to moderate protein binding (10-49%). Unknown if it crosses the placenta, blood-brain barrier, or enters maternal milk.

代謝

Not extensively described in the monograph.

消失

Eliminated primarily via the kidneys. About 63% of a dose is excreted (10-40% unchanged) into the urine. Duration of effect is dose-related (30 minutes to 2 hours in humans).

過剰投与

Because hypotension is the primary problem that would generally be seen, circulatory support should be instituted immediately. Only one human case of accidental massive overdose resulting in death has been reported (causal relationship not unequivocally established).

製品

製剤

  • Injection

ヒト用医薬品

  • Inamrinone Lactate for Injection: 5 mg/mL (as lactate) in 20 mL ampules

規制ステータス

規制データなし: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU

保管・安定性

Store at room temperature and protect from light. Stable for 2 years after manufacture. Compatible with 0.45% or 0.9% sodium chloride injection. Incompatible with solutions containing dextrose or sodium bicarbonate.

飼主向け情報

  • ​院内使用限定：​ この薬は、集中治療が可能な病院でのみ静脈内投与されます。
  • ​試験的な使用：​ 犬や猫に対するこの薬の使用は「試験的（適応外使用）」な性質があることをご理解ください。
  • ​厳密なモニタリング：​ この薬の投与中は、ペットの心拍リズム（心電図）と血圧を継続的に監視する必要があります。

VetSheet医薬品リファレンスは獣医専門家の臨床意思決定支援を目的としており、専門的判断または製造業者の最新医薬品情報の代替にはなりません。