リシノプリル

動物種別の用量

用量は獣医療従事者向けの臨床リファレンスです。必ず最新の添付文書と個々の患者で確認してください。

投与経路

禁忌

• Known hypersensitivity to ACE inhibitors
• Pregnancy (especially 2nd and 3rd trimesters)

有害事象

• Anorexia
• Vomiting
• Diarrhea
• Lethargy or weakness
• Hypotension
• Renal dysfunction (azotemia)
• Hyperkalemia
• Cough (rare in animals compared to humans)

薬物相互作用

• Antidiabetic Agents (insulin, oral agents) · Possible increased risk for hypoglycemia; enhanced monitoring recommended.
• Diuretics (e.g., furosemide, hydrochlorothiazide) · Potential for increased hypotensive effects; reducing furosemide doses (by 25-50%) is often recommended when initiating ACE inhibitors in CHF.
• Potassium-Sparing Diuretics (e.g., spironolactone, triamterene) · Increased risk of hyperkalemia; enhanced monitoring of serum potassium recommended.
• Other Hypotensive Agents · Potential for additive hypotensive effects.
• Lithium · Increased serum lithium levels possible; increased monitoring required.
• NSAIDs · May reduce the anti-hypertensive or positive hemodynamic effects of lisinopril; may increase the risk of acute renal failure.
• Potassium Supplements · Increased risk for hyperkalemia.

モニタリング

• Clinical signs of CHF (respiratory rate/effort, exercise tolerance)
• Blood pressure (especially upon initiation or dose changes)
• Serum electrolytes (specifically potassium)
• Renal panel (BUN, Creatinine)
• Urine protein
• Periodic CBC with differential

過量投与

The primary concern with overdosage is **hypotension**. * **Toxicity Thresholds**: In dogs, the lowest dosage documented to cause hypotension is 27 mg/kg. Dosages below 20 mg/kg generally cause only mild signs (vomiting, lethargy). In cats, hypotension was noted at 4.9 mg/kg in a single case. In birds, mild somnolence occurred at 41 mg/kg. * **Clinical Signs**: Hypotension, lethargy, vomiting, and tachycardia. * **Treatment**: Recent overdoses should be managed using gut-emptying protocols when warranted. Supportive treatment with **volume expansion using normal saline** is recommended to correct blood pressure. Due to the drug's long duration of action, prolonged monitoring and treatment may be required.