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中鎖脂肪酸トリグリセリド (MCTオイル)

Medium Chain Triglycerides (MCT Oil)

Triglycerida saturata media

栄養補助食品 / 脂質PO犬猫

別名: MCT Oil · Alembicol D · Liprocil · Liquigen · Mytic 810 · Structolipid · Teceeme · Triglycerida saturata media · Caprylic/Capric Triglycerides

VetSheet 獣医チームが監修更新日 2026年4月5日エビデンスに基づく獣医学リファレンス

0.5-2 mL/kg per day added to foodPO· daily
— 🐕

用量は獣医専門家向けの臨床参考資料です。必ず最新の医薬品情報および個別症例に基づいて確認してください。

動物種別用量

🌎 NA — North America🌍 EU — Europe

犬

適応用量経路頻度期間地域
To offset caloric reduction when long-chain triglycerides are restricted½-4 teaspoons divided per day with foodPOdivided daily—🌎 NA
To offset caloric reduction when long-chain triglycerides are restricted0.5-2 mL/kg per day added to foodPOdaily—🌎 NA
To offset caloric reduction when long-chain triglycerides are restricted1-2 mL/kg per dayPOdaily—🌎 NA

猫

適応用量経路頻度期間地域
Base-vehicle to administer drugs0.1 mL/kgPOas needed—🌎 NA
  • Base-vehicle to administer drugs: Owner-perceived acceptability by cats of MCT oil was significantly higher than gelatin capsules.

用量は獣医専門家向けの臨床参考資料です。必ず最新の医薬品情報および個別症例に基づいて確認してください。

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概要

中鎖脂肪酸トリグリセリド（MCT）は、小腸の慢性浸潤性疾患や脂肪吸収不良症候群により脂肪制限が必要な犬にカロリーを提供するために使用される脂質サプリメントです。猫では経口薬の基剤として使用されることもあります。

作用機序

MCTs bypass the traditional, complex lipid digestion and absorption pathways required by long-chain triglycerides (LCTs):

Triglycerides → hydrolyzed by gastric and pancreatic lipases (requires significantly less bile acids than LCTs) → ​Medium-chain fatty acids (MCFAs)​ → absorbed directly into enterocytes → enter the portal vein directly (bypassing chylomicron formation and lymphatic transport) → rapid oxidation in the liver for immediate energy.

Because they do not rely on the lymphatic system, they are ideal for patients with lymphatic obstruction or dilation (e.g., lymphangiectasia).

安全性・警告

禁忌

  • Significant hepatic disease (e.g., portosystemic shunts, cirrhosis, hepatic failure)

有害事象

  • Unpalatability (especially in dogs)
  • Bloating
  • Flatulence
  • Diarrhea
  • Food aversion (rare in cats)

注意事項

​Hepatic Disease Warning:​ Use with extreme caution in patients with significant hepatic disease (e.g., portacaval shunts, cirrhosis). Because MCTs are rapidly absorbed via the portal vein, impaired hepatic clearance can lead to significantly high systemic blood and cerebrospinal fluid (CSF) levels of medium-chain fatty acids. This can precipitate or exacerbate hepatic encephalopathy/coma.

  • ​Gastrointestinal Upset:​ Rapid introduction can cause severe osmotic diarrhea. Always start at the low end of the dose range and titrate up gradually.
  • ​Nutritional Deficiencies:​ Does not provide essential fatty acids. Fat-soluble vitamin supplementation is recommended if used as the primary fat source.

医薬品相互作用

Griseofulvin

MCT oil may decrease absorption, as griseofulvin requires long-chain dietary fats for optimal oral absorption.

Fat-soluble vitamins (A, D, E, K)

Absorption may be impaired if LCTs are completely replaced by MCTs; supplementation may be required.

監視

  • Gastrointestinal tolerance (vomiting, bloating, flatulence, stool consistency)
  • Efficacy (maintenance of body weight and body condition score)
  • Signs of hepatic encephalopathy in patients with underlying liver disease

薬物動態

吸収

Rapidly hydrolyzed and absorbed directly into the enterocytes. Requires less bile acids for digestion compared to long-chain fats.

分布

Transported directly via the portal vein to the liver. Not dependent on chylomicron formation or lymphatic transport.

代謝

Rapidly oxidized in the liver to provide energy.

消失

Primarily utilized for energy; minimal elimination of intact MCTs.

過剰投与

Overdosage primarily exacerbates gastrointestinal adverse effects, leading to bloating, flatulence, and severe diarrhea.

​Treatment:​

  • Discontinue or reduce the dose of MCT oil.
  • Treat severe diarrhea supportively (e.g., fluid therapy to correct dehydration and electrolyte imbalances) if necessary.

製品

製剤

  • Oral oil liquid

ヒト用医薬品

  • Medium Chain Triglycerides Oil: in quart bottles; MCT (Mead Johnson Nutritionals); (OTC)

規制ステータス

規制データなし: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU

保管・安定性

Unless otherwise noted by the manufacturer, store at room temperature in glass bottles.

飼主向け情報

MCTオイルは犬にとって嗜好性が低いため、与える前に少量の食事によく混ぜてください。下痢や鼓腸が起こる可能性があるため、低用量から始めて徐々に増やすことをお勧めします。重度の下痢が見られる場合は獣医師にご相談ください。

VetSheet医薬品リファレンスは獣医専門家の臨床意思決定支援を目的としており、専門的判断または製造業者の最新医薬品情報の代替にはなりません。