メチオニン

動物種別の用量

用量は獣医療従事者向けの臨床リファレンスです。必ず最新の添付文書と個々の患者で確認してください。

投与経路

禁忌

• Renal failure
• Pancreatic disease
• Hepatic insufficiency
• Preexisting acidosis
• Oxalate or urate calculi
• Kittens
• Pre-existing metabolic acidosis
• Severe liver disease or hepatic encephalopathy
• Urate, cystine, or calcium oxalate urolithiasis
• Young growing animals
• Pregnant or nursing animals

有害事象

• Gastrointestinal distress (nausea, vomiting)
• Heinz-body hemolytic anemia (especially in cats)
• Methemoglobinemia
• Ataxia
• Cyanosis
• Metabolic acidosis
• Gastrointestinal upset (nausea, vomiting, diarrhea)
• Heinz body anemia (especially in cats at high doses)
• Worsening of hepatic encephalopathy in patients with liver disease

薬物相互作用

• Aminoglycosides (gentamicin, amikacin) · Urine acidification may diminish the effectiveness of aminoglycosides in treating bacterial urinary tract infections, as they are more effective in an alkaline medium.
• Erythromycin · Urine acidification may diminish the effectiveness of erythromycin in treating bacterial urinary tract infections.
• Quinidine · Urine acidification may increase the renal excretion of quinidine, potentially lowering its systemic levels.
• Other urinary acidifiers (e.g., ammonium chloride) · Additive acidification leading to severe metabolic acidosis · major
• Urinary acidifying diets · Excessive lowering of urine pH and increased risk of metabolic acidosis · major

モニタリング

• Urine pH (goal of therapy is typically ≤6.5)
• Blood pH (if signs of toxicity or metabolic acidosis are present)
• CBC in cats (if exhibiting signs of toxicity, to check for Heinz-body anemia)
• Urine pH
• Complete Blood Count (CBC) to monitor for Heinz bodies, especially in cats
• Acid-base status (blood gases) if overdosage is suspected
• Liver function

過量投与

**Feline Toxicity:** Cats are particularly sensitive to methionine overdose. * When administered at a dose of 2 grams orally per day to mature cats, it caused **anorexia, methemoglobinemia, Heinz body formation (with resultant hemolytic anemia), ataxia, and cyanosis**. * **Kittens:** Methionine may be highly toxic to kittens who consume other cats' food to which methionine has been added. **General Toxicity:** Metabolic acidosis can occur with overdoses in any species, particularly when used in combination with an acidifying diet. No specific information was located on the treatment of methionine overdosage; treatment should be symptomatic and supportive (e.g., correcting acid-base imbalances).