ムピロシン
ムピロシンは独自の化学構造を持つ局所用抗生物質であり、主に他の薬剤に耐性を示す細菌性皮膚感染症（特にブドウ球菌）の管理に用いられます。人医療ではMRSAの除菌のために予約されています。**臨床上の警告**：代替の治療選択肢がない場合にのみ使用し、耐性菌の発生を抑えるため7日間を超えて使用しないでください。
作用機序: Mupirocin blocks protein synthesis in bacteria by reversibly and specifically binding to and inhibiting **bacterial isoleucyl-tRNA synthetase** → prevents the incorporation of isoleucine into growing protein chains → halts bacterial growth and replication.
動物種別の用量
- Bacterial skin infections (pyotraumatic dermatitis, intertrigo, callus pyoderma, acne) · Apply a thin layer of cream to infected areas · topical · q8h · Maximum 7 days · 10 minutes contact time is required for activity.
- Bacterial skin infections (including feline acne) · Apply a thin layer of cream to infected areas · topical · q8h · Maximum 7 days · 10 minutes contact time is required for activity.
用量は獣医療従事者向けの臨床リファレンスです。必ず最新の添付文書と個々の患者で確認してください。
投与経路
禁忌
- Patients with known renal impairment (due to potential systemic absorption of the polyethylene glycol vehicle in some ointment formulations)
- Deep puncture wounds or severe burns
有害事象
- Stinging sensation at the application site
- Local irritation or erythema
モニタリング
- Resolution of clinical signs of skin infection
- Signs of local irritation or hypersensitivity at the application site
過量投与
Systemic toxicity from topical overdosage is highly unlikely due to minimal absorption and rapid metabolism of any absorbed drug. Ingestion may cause mild gastrointestinal upset. **Clinical Pearl:** The primary concern with excessive application is local irritation or potential toxicity from the polyethylene glycol (PEG) base in patients with renal compromise.
VetSheet の薬剤リファレンスは、獣医療従事者向けの臨床意思決定支援を目的としており、専門的判断やメーカーの最新添付文書に代わるものではありません。