ナンドロロンデカン酸エステル
Nandrolone Decanoate
Nortestosterone decanoate
別名: Deca-Durabolin · Nortestosterone decanoate · Nortestosterone decylate
VetSheet 獣医チームが監修更新日 2026年4月5日エビデンスに基づく獣医学リファレンス
用量は獣医専門家向けの臨床参考資料です。必ず最新の医薬品情報および個別症例に基づいて確認してください。
動物種別用量
🌎 NA — North America🌍 EU — Europe
犬
| 適応 | 用量 | 経路 | 頻度 | 期間 | 地域 |
|---|---|---|---|---|---|
| Adjunctive treatment of chronic idiopathic myelofibrosis | 2 mg/kg IM weekly | IM | weekly | 3 weeks | 🌎 NA |
| Disuse muscle atrophy secondary to immobilization | 1.5 mg/kg IM once weekly | IM | once weekly | up to 8 weeks | 🌎 NA |
| Treatment of anemia in patients with chronic renal failure | 1-1.5 mg/kg IM once weekly | IM | once weekly | May require 2-3 months to achieve beneficial effects | 🌎 NA |
| Treatment of anemia in patients with chronic renal failure | 5 mg/kg IM (maximum of 200 mg/week) every 2-3 weeks | IM | every 2-3 weeks | — | 🌎 NA |
| Treatment of metabolic and endocrine anemias | 5 mg/kg IM once weekly | IM | once weekly | — | 🌎 NA |
| Aplastic anemia | 1-3 mg/kg IM weekly | IM | weekly | — | 🌎 NA |
| Appetite stimulant | 5 mg/kg IM weekly | IM | weekly | — | 🌎 NA |
- Adjunctive treatment of chronic idiopathic myelofibrosis: Used with prednisolone (2-3 mg/kg PO once daily for 3-4 weeks, then tapered). If anemia does not respond, azathioprine may be added.
- Disuse muscle atrophy secondary to immobilization: Start from the day of surgery/immobilization.
- Treatment of anemia in patients with chronic renal failure: Evidence to support use is poor.
- Treatment of metabolic and endocrine anemias: Maximum of 200 mg. Most resolve with correction of underlying disease process.
- Appetite stimulant: Maximum 200 mg/week.
猫
| 適応 | 用量 | 経路 | 頻度 | 期間 | 地域 |
|---|---|---|---|---|---|
| FeLV-induced anemia or as a general bone marrow stimulant | 10-20 mg IM once weekly | IM | once weekly | — | 🌎 NA |
| Chronic anemia secondary to feline cardiomyopathy | 50 mg IM weekly | IM | weekly | — | 🌎 NA |
- FeLV-induced anemia or as a general bone marrow stimulant: Is of questionable benefit.
爬虫類
| 適応 | 用量 | 経路 | 頻度 | 期間 | 地域 |
|---|---|---|---|---|---|
| To reduce protein catabolism in renal disease of lizard species | 1 mg/kg IM every 7-28 days | IM | every 7-28 days | — | 🌎 NA |
用量は獣医専門家向けの臨床参考資料です。必ず最新の医薬品情報および個別症例に基づいて確認してください。
概要
ナンドロロンデカン酸エステルは注射用アナボリックステロイドであり、過去には特定の貧血（慢性腎不全など）の患者における赤血球生成の促進や、食欲増進剤として使用されていました。現在ではより安全で効果的な代替薬（エリスロポエチンやミルタザピンなど）があるため、獣医療で推奨・使用されることは稀です。スケジュールIII規制薬物 (C-III)に指定されています。
作用機序
Nandrolone is a synthetic derivative of testosterone with enhanced anabolic and reduced androgenic properties.
- Anabolic Effects: Binds to intracellular androgen receptors (AR) → translocates to the nucleus → alters gene transcription. In the presence of adequate protein and calories, it promotes body tissue-building processes and reverses catabolism.
- Erythropoiesis Stimulation: Enhances red blood cell counts by directly stimulating red cell precursors in the bone marrow, increasing red cell 2,3-diphosphoglycerate (2,3-DPG), and stimulating erythropoietin (EPO) production in the kidneys.
- Endocrine Feedback: Suppresses endogenous testosterone release by inhibiting luteinizing hormone (LH). Large doses impede spermatogenesis via negative feedback inhibition of follicle-stimulating hormone (FSH).
- Metabolic Effects: Causes retention of nitrogen, sodium, potassium, and phosphorus, and decreases urinary excretion of calcium.
安全性・警告
禁忌
- Hepatic dysfunction
- Hypercalcemia
- History of myocardial infarction
- Pituitary insufficiency
- Prostate carcinoma
- Mammary carcinoma
- Benign prostatic hypertrophy (BPH)
- Nephrotic stage of nephritis
- Pregnancy (FDA Category X - known teratogen)
有害事象
- Sodium, calcium, potassium, water, chloride, and phosphate retention
- Hepatotoxicity
- Behavioral changes (androgenic effects, e.g., increased aggression)
- Reproductive abnormalities (oligospermia, estrus suppression)
- Masculinization of female fetuses (teratogenic)
注意事項
Pregnancy Warning: FDA Category X. Anabolic steroids can cause masculinization of the fetus. The risk of use in pregnant animals clearly outweighs any possible benefit.
- Nursing Mothers: It is unknown if anabolic steroids are excreted in maternal milk. Due to the potential for serious adverse reactions in nursing offspring, a decision should be made to either discontinue nursing or discontinue the drug.
- Laboratory Alterations: Can decrease protein-bound iodine (PBI), thyroxine-binding globulin, and total T4 concentrations while increasing resin uptake of T3 and T4 (free thyroid hormones remain unaltered). Can decrease creatinine and creatine excretion, increase 17-ketosteroid excretion, alter blood glucose, suppress clotting factors (II, V, VII, X), and elevate liver enzymes (AST, ALT, ALP, bilirubin).
医薬品相互作用
Anabolic agents may potentiate the effects of anticoagulants; monitoring of INR and dosage adjustment of the anticoagulant are recommended.
Anabolics may enhance the edema that can be associated with ACTH or adrenal steroid therapy.
Anabolics may decrease blood glucose and decrease insulin requirements; diabetic patients may need dosage adjustments.
監視
- Androgenic side effects (behavioral changes)
- Fluid and electrolyte status (especially sodium, potassium, calcium)
- Liver function tests (AST, ALT, ALP, bilirubin)
- Red blood cell count and indices
- Weight and appetite
薬物動態
吸収
Administered via deep intramuscular injection. The decanoate ester provides a slow release from the injection site.
分布
No specific veterinary information located.
代謝
Metabolized in the liver.
消失
No specific veterinary information located.
過剰投与
No specific information was located for this agent in veterinary species. In humans, sodium and water retention can occur after overdosage of anabolic steroids.
- Treatment: Treat supportively. Monitor liver function and electrolyte status should an inadvertent overdose be administered.
製品
製剤
- Injectable solution (compounded, typically in sesame oil)
動物用医薬品
- None commercially available in the USA. Potentially available from compounding pharmacies.
ヒト用医薬品
- None commercially available in the USA.
規制ステータス
規制データなし: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
保管・安定性
Store at temperatures less than 40°C, preferably between 15-30°C (59-86°F). Protect from freezing and light.
飼主向け情報
- 規制薬物：人間による乱用の可能性があるため、この薬はスケジュールIII規制薬物 (C-III) に指定されています。子供の手の届かない安全な場所に保管してください。
- 副作用の観察：行動の変化（攻撃性の増加など）、むくみ、または黄疸（肝機能障害の兆候）がないかペットを注意深く観察してください。
- 定期的な診察：治療中は、肝機能や赤血球数を監視するために定期的な血液検査が必要です。
VetSheet医薬品リファレンスは獣医専門家の臨床意思決定支援を目的としており、専門的判断または製造業者の最新医薬品情報の代替にはなりません。