プロリゲストン
**プロリゲストン**は、主に犬や猫の発情の延期または抑制に使用される合成プロゲストーゲンです。猫の粟粒性皮膚炎の治療にも認可されていますが、この適応症には通常、特定のグルココルチコイドが推奨されます。 > **臨床上の警告**: プロリゲストンには、嚢胞性子宮内膜増殖症（子宮蓄膿症）、糖尿病、乳腺腫瘍の発生リスクなど、長期的なプロゲストーゲン使用に特有のリスクがあります。慎重に使用する必要があり、糖尿病の動物には禁忌です。
作用機序: Proligestone alters the transcription of DNA → leads to alterations in cellular metabolism → mimics the physiological effects caused by endogenous **progesterone**.
動物種別の用量
- Suppression of oestrus · 10-33 mg/kg depending on body weight (<5kg: 100-150mg; 5-10kg: 150-250mg; 10-20kg: 250-350mg; 20-30kg: 350-450mg; 30-45kg: 450-550mg; 45-60kg: 550-600mg; >60kg: 10 mg/kg) · SC · Once · Single dose · Given once for suppression. Inject into medial side of flank fold.
- Permanent postponement of oestrus · 10-33 mg/kg depending on body weight (see weight table) · SC · 1st dose before pro-oestrus, 2nd dose 3 months later, 3rd dose 4 months later, then every 5 months · Ongoing · Once dosing ceases, bitches may come into oestrus on average 6-7 months later, but it may take up to 3 years in some cases.
- Acromegaly · 10-33 mg/kg depending on body weight (see weight table) · SC · Monthly · Until signs of hair growth are evident
- Postponement of oestrus / Miliary dermatitis · Dose not explicitly specified in text; refer to manufacturer guidelines · SC · Not specified · Not specified · Authorized for miliary dermatitis, but specific glucocorticoids are preferred.
用量は獣医療従事者向けの臨床リファレンスです。必ず最新の添付文書と個々の患者で確認してください。
投与経路
禁忌
- Diabetic animals (insulin requirements are likely to change unpredictably)
- Bitches before or at their first oestrus
有害事象
- Unpredictable duration of anoestrus (up to 3 years in some bitches)
- Temperament changes (listlessness and depression)
- Polyuria and polydipsia (increased thirst)
- Polyphagia (increased appetite)
- Cystic endometrial hyperplasia / Pyometra
- Diabetes mellitus
- Acromegaly
- Adrenocortical suppression
- Mammary enlargement, lactation, or neoplasia
- Injection site irritation
- Coat colour changes at the injection site
- Calcinosis circumscripta at the injection site
モニタリング
- Signs of pyometra (vaginal discharge, lethargy, polyuria/polydipsia)
- Blood glucose and clinical signs of diabetes mellitus (excessive thirst and urination)
- Mammary gland changes (enlargement, masses)
- Injection site reactions
過量投与
No specific information provided in the monograph. Overdosage may increase the risk and severity of progestational side effects, including cystic endometrial hyperplasia, diabetes mellitus, and adrenocortical suppression. Treatment is supportive.
VetSheet の薬剤リファレンスは、獣医療従事者向けの臨床意思決定支援を目的としており、専門的判断やメーカーの最新添付文書に代わるものではありません。