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サイリウム

Psyllium

Psyllium hydrophilic mucilloid

膨張性消化管下剤 / 止瀉薬PONasogastric (NG) tube犬猫馬

別名: Metamucil · Equi-Psyllium · Sandclear · Vetasyl · Plantago seed · Psyllium seed husk · Ispaghula

VetSheet 獣医チームが監修更新日 2026年4月5日エビデンスに基づく獣医学リファレンス

2 tablespoonsful (1.33 grams/kg/day; range: 0.32-4.9 grams/kg/day) per day added to a highly digestible dietPO· q24h
— 🐕

用量は獣医専門家向けの臨床参考資料です。必ず最新の医薬品情報および個別症例に基づいて確認してください。

動物種別用量

🌎 NA — North America🌍 EU — Europe

犬

適応用量経路頻度期間地域
Trial to treat chronic idiopathic large bowel diarrhea2 tablespoonsful (1.33 grams/kg/day; range: 0.32-4.9 grams/kg/day) per day added to a highly digestible dietPOq24h—🌎 NA
To increase fiber in dogs with chronic colitis1-2 tablespoonsful (15-30 mL) per 25 kg body weightPOq24h—🌎 NA
Predominantly large bowel diarrhea (therapeutic trial)0.5 tablespoon for toy breeds, 1 tablespoon for small dogs, 2 tablespoons for medium dogs, and 3 tablespoons for large dogsPOq24h5-10 days🌎 NA
Dogs prone to constipation2% psyllium added as part of dietPOq24h—🌎 NA
Adjunct (source of soluble fiber) for treatment of hepatic encephalopathy1-3 teaspoons per day as a dietary supplementPOq24h—🌎 NA
  • Trial to treat chronic idiopathic large bowel diarrhea: Using Metamucil
  • To increase fiber in dogs with chronic colitis: Add to animal's regular diet
  • Predominantly large bowel diarrhea (therapeutic trial): Given alongside metronidazole 20-25 mg/kg PO twice daily
  • Dogs prone to constipation: 80% of studied dogs had easier defecation process

猫

適応用量経路頻度期間地域
Chronic constipation1-4 teaspoonsful per meal added to canned cat foodPOper meal—🌎 NA
Adjunctive treatment of feline megacolon1-4 teaspoonsful mixed with foodPOq12-24h—🌎 NA
  • Chronic constipation: Be sure cat is properly hydrated

馬

適応用量経路頻度期間地域
Sand colic1 gram/kgPO / NG tubeq12h—🌎 NA
Sand colic0.5 kg mixed with 1 liter of mashPOq12h—🌎 NA
Sand impactions8 ounces in waterNG tubeq24h—🌎 NA
  • Sand colic: Mix approx 1 lb powder with water and administer immediately via NG tube. If giving orally to foals, give small amounts to prevent esophageal obstruction. Pelleted form is more palatable.
  • Sand colic: Given with 2 liters of mineral oil via NG tube once daily

用量は獣医専門家向けの臨床参考資料です。必ず最新の医薬品情報および個別症例に基づいて確認してください。

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概要

サイリウムは膨張性下剤であり、主に馬の砂疝の治療と予防、および便秘の緩下剤として使用されます。また、慢性の水様性下痢の患者において便の硬さを増すためにも使用されます。

​臨床のポイント​：水溶性食物繊維であり、腸内で水分を吸収して膨張し、蠕動運動を促進します。下痢の際の便の硬さを改善しますが、便中の総水分量は変化しません。

作用機序

Psyllium acts primarily through mechanical and physical mechanisms in the gastrointestinal tract:

  • ​Water Absorption:​ The hemicellulose mucilage absorbs water in the intestinal lumen and swells.
  • ​Peristalsis Induction:​ The increased bulk distends the intestinal wall → stimulates stretch receptors → induces peristalsis and decreases overall intestinal transit time.
  • ​Sand Clearance (Horses):​ The mucilaginous gel formed by psyllium helps collect and bind sand, lubricating its passage through the GI tract for elimination.

安全性・警告

禁忌

  • Rabbits (may damage intestinal mucosa and cause blockage)
  • Fecal impaction (no feces being passed)
  • Intestinal obstruction
  • Conditions where prompt intestinal evacuation is required

有害事象

  • Flatulence
  • Esophageal obstruction (if administered with insufficient liquid)
  • Bowel obstruction (if administered with insufficient liquid)

注意事項

Bulk-forming laxatives must be administered with adequate water. If insufficient liquid is given, there is an increased possibility of esophageal or bowel obstruction occurring. Do not use in rabbits. Safe for use in pregnant and lactating animals (FDA Category B equivalent), as there is no appreciable systemic absorption.

医薬品相互作用

Aspirin (and other salicylates)

Potential exists for psyllium to bind and reduce absorption if given at the same time; separate doses by 3 hours or more.

Digoxin

Potential exists for psyllium to bind and reduce absorption if given at the same time; separate doses by 3 hours or more.

Nitrofurantoin

Potential exists for psyllium to bind and reduce absorption if given at the same time; separate doses by 3 hours or more.

監視

  • Stool consistency
  • Defecation frequency
  • Hydration status

薬物動態

吸収

Not absorbed when administered orally.

分布

Remains locally in the gastrointestinal tract.

代謝

Not metabolized systemically; may undergo partial fermentation by colonic bacteria.

消失

Excreted unchanged in feces. Laxative action may take up to 72 hours to occur.

過剰投与

If administered with sufficient liquid, psyllium overdose should cause only an increased amount of soft or loose stools. If administered without sufficient liquid, risk of severe esophageal or intestinal obstruction increases.

製品

製剤

  • Powder
  • Pellets
  • Tablets
  • Capsules

動物用医薬品

  • Equine Enteric Colloid (Techmix)
  • Equi-Phar Sweet Psyllium (Vedco)
  • Sandclear (Farnam)
  • Anipsyll Powder (AHC)
  • Purepsyll Powder (AHC)
  • Vita-Flex Sand Relief (Vita-lex)
  • Equa Aid Psyllium (Equi Aid)
  • Vetasyl Fiber Tablets for Cats 500 mg & 1000 mg (Virbac)

ヒト用医薬品

  • Metamucil (approx 3.4 grams of psyllium per rounded teaspoonful)
  • Various generic OTC psyllium powders and capsules

規制ステータス

規制データなし: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU

保管・安定性

Store psyllium products in tightly closed containers; protect from excess moisture or humidity.

飼主向け情報

​重要な警告​：このサプリメントを服用している間、ペットが常に新鮮な水を飲めるようにしてください。水分が不足すると、サイリウムが喉や腸内で膨張し、危険な閉塞を引き起こす可能性があります。

  • ​投与方法​：犬や猫の場合、十分な水分摂取を確保するため、粉末や顆粒をウェットフードや缶詰に混ぜることを強くお勧めします。
  • ​獣医師への連絡​：ペットが嘔吐し始めたり、腹痛の兆候を示したり、便が出ないのに排便しようと力んだりする場合は、すぐに獣医師に連絡してください。
  • ​効果の発現​：完全な排便効果が現れるまでに最大3日（72時間）かかる場合があります。

VetSheet医薬品リファレンスは獣医専門家の臨床意思決定支援を目的としており、専門的判断または製造業者の最新医薬品情報の代替にはなりません。