セコバルビタールおよびシンコカイン
Secobarbital and Cinchocaine
Secobarbital / Cinchocaine
別名: Somulose · Quinalbarbitone/Cinchocaine · Secobarbital sodium/Cinchocaine hydrochloride
VetSheet 獣医チームが監修更新日 2026年4月5日エビデンスに基づく獣医学リファレンス
用量は獣医専門家向けの臨床参考資料です。必ず最新の医薬品情報および個別症例に基づいて確認してください。
動物種別用量
🌎 NA — North America🌍 EU — Europe
犬
| 適応 | 用量 | 経路 | 頻度 | 期間 | 地域 |
|---|---|---|---|---|---|
| Euthanasia | 0.25 ml/kg | IV | once | over 10-15 seconds | 🌍 EU |
- Euthanasia: Administer over 10-15 seconds to minimize premature cardiac arrest. IV catheter recommended.
猫
| 適応 | 用量 | 経路 | 頻度 | 期間 | 地域 |
|---|---|---|---|---|---|
| Euthanasia | 0.25 ml/kg | IV | once | over 10-15 seconds | 🌍 EU |
- Euthanasia: Administer over 10-15 seconds to minimize premature cardiac arrest. IV catheter recommended.
用量は獣医専門家向けの臨床参考資料です。必ず最新の医薬品情報および個別症例に基づいて確認してください。
概要
バルビツール酸系（セコバルビタール）と局所麻酔薬（シンコカイン）を組み合わせた強力な動物用安楽死薬であり、犬および猫の安楽死に専ら使用されます。臨床上の警告： 人間に対して非常に毒性が高いため、誤って自己注射しないよう細心の注意が必要です。麻酔目的での使用は厳禁です。
作用機序
The combination works synergistically to ensure rapid and peaceful euthanasia:
- Secobarbital → Rapidly and profoundly depresses the Central Nervous System (CNS), including the respiratory centers, leading to rapid loss of consciousness and cessation of respiration.
- Cinchocaine → Exerts marked cardiotoxic effects at high doses. It depresses cardiac conduction → resulting in early cardiac arrest.
Clinical Pearl: Because cardiac arrest is not dependent on the development of profound hypoxia, euthanasia with this combination is generally not accompanied by the agonal gasping that may occur with other agents.
安全性・警告
禁忌
- Must NOT be used for anesthesia (non-sterile and cardiotoxic)
有害事象
- Pain on injection (if administered perivascularly)
- Excitement (if administered perivascularly or too slowly)
注意事項
Patient Precautions
- Injection Speed: Speed of injection is critical. An injection rate that is too slow may induce normal collapse but prolong the period until death. Administer over 10-15 seconds to minimize premature cardiac arrest before unconsciousness.
- Route: Strictly intravenous. Perivascular administration may delay the onset of effect, cause pain, and result in excitement. Placement of an IV catheter is strongly recommended.
- Always have an alternative method of euthanasia available.
Human Safety Warnings
EXTREME DANGER TO HUMANS: Rapidly and highly toxic.
- Use an IV catheter instead of a needle whenever possible to prevent accidental needle-stick injuries.
- Only administer in the presence of an assistant.
- Wear suitable protective gloves. Cinchocaine can cause hypersensitivity and severe contact dermatitis following skin contact.
- Wash off splashes from skin and eyes immediately.
- In the event of accidental self-administration: Do not leave the person unattended. Seek URGENT medical assistance, advise medical services of barbiturate and local anesthetic poisoning, and show the label. Maintain airways and provide symptomatic/supportive treatment.
監視
- Confirmation of cardiac arrest (auscultation)
- Confirmation of respiratory arrest
- Absence of corneal reflex
- Loss of pupillary light reflex
薬物動態
吸収
Rapid onset following intravenous administration.
分布
Rapidly distributes to the CNS.
過剰投与
Not applicable. This medication is intended to induce death.
製品
製剤
- Injectable: 400 mg/ml secobarbital with 25 mg/ml cinchocaine solution
動物用医薬品
- Somulose Injectable Solution (400 mg/ml secobarbital, 25 mg/ml cinchocaine)
規制ステータス
Controlled Drug
POM-V CD SCHEDULE 2
規制データなし: 🇺🇸 US · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
保管・安定性
Store in a locked receptacle in accordance with Controlled Drug Schedule 2 regulations.
飼主向け情報
この薬剤は、獣医療の専門家がペットの安楽死を行うためにのみ使用されます。迅速で痛みがなく、安らかな最期を迎えることができるよう設計されています。
VetSheet医薬品リファレンスは獣医専門家の臨床意思決定支援を目的としており、専門的判断または製造業者の最新医薬品情報の代替にはなりません。