VetSheet

スタノゾロール

Stanozolol

17alpha-Methyl-5alpha-androstano[3,2-c]pyrazol-17beta-ol (Androstanazole)

アナボリックステロイドPOIMSC犬猫小型哺乳類フェレット鳥爬虫類馬羊ヤギ

別名: Winstrol-V · Menabol · Neurabol · Stanol · Strombaject · Androstanazole · Estanozolol · Methylstanazole · NSC-43193 · Stanozololum · Win-14833

VetSheet 獣医チームが監修更新日 2026年4月5日エビデンスに基づく獣医学リファレンス

2 mg/kg IM for 4-6 weeks with 1-2 mg (total dose) PO once daily for dogs less than 23 kg and 4 mg (total dose) PO once daily for dogs greater than 23 kg.IM/PO· q24h (PO)· 4-6 weeks initially
— 🐕

用量は獣医専門家向けの臨床参考資料です。必ず最新の医薬品情報および個別症例に基づいて確認してください。

動物種別用量

🌎 NA — North America🌍 EU — Europe

犬

適応用量経路頻度期間地域
As an anabolic agent per labeled indications (Small Breeds)1-2 mg PO twice daily; or 25 mg deep IM, may repeat weekly.PO/IMq12h (PO) or weekly (IM)Several weeks, depending on response🌎 NA
As an anabolic agent per labeled indications (Large Breeds)2-4 mg PO twice daily; or 50 mg deep IM, may repeat weekly.PO/IMq12h (PO) or weekly (IM)Several weeks, depending on response🌎 NA
For anemia secondary to chronic renal failure1-4 mg PO once dailyPOq24h—🌎 NA
For anemias secondary to uremia2-10 mg PO twice dailyPOq12h—🌎 NA
As an anabolic/appetite stimulant1-4 mg PO twice daily OR 1-2 mg PO twice daily or 25-50 mg IM weeklyPO/IMq12h (PO) or weekly (IM)—🌎 NA
For canine cognitive dysfunction2 mg/kg IM for 4-6 weeks with 1-2 mg (total dose) PO once daily for dogs less than 23 kg and 4 mg (total dose) PO once daily for dogs greater than 23 kg.IM/POq24h (PO)4-6 weeks initially🌎 NA
  • For canine cognitive dysfunction: If drug has some positive effect, maintain oral dosing and gradually reduce injections to every 3-4 weeks.

猫

適応用量経路頻度期間地域
As an anabolic agent per labeled indications1-2 mg PO twice daily; or 25 mg deep IM, may repeat weekly.PO/IMq12h (PO) or weekly (IM)Several weeks, depending on response🌎 NA
  • As an anabolic agent per labeled indications: EXTREME CAUTION: High incidence of hepatotoxicity in cats.

小型哺乳類

適応用量経路頻度期間地域
As an appetite stimulant (Rabbits)0.5-2 mg PO oncePOOnceSingle dose🌎 NA

フェレット

適応用量経路頻度期間地域
General therapeutics0.5 mg/kg PO or SC twice dailyPO/SCq12h—🌎 NA
  • General therapeutics: Use with caution in hepatic disease.

鳥

適応用量経路頻度期間地域
As an anabolic agent to promote weight gain and recovery from disease0.5-1 mL/kg (25-50 mg/kg) IM once or twice weekly.IMOnce or twice weekly—🌎 NA
  • As an anabolic agent to promote weight gain and recovery from disease: Use with caution in birds with renal disease.

爬虫類

適応用量経路頻度期間地域
Post-surgically and in very debilitated animals5 mg/kg IM once a week as neededIMweeklyAs needed🌎 NA

馬

適応用量経路頻度期間地域
As an anabolic agent per labeled indications0.55 mg/kg (25 mg per 100 pounds of body weight) IM deeply. May repeat weekly for up to and including 4 weeks.IMweeklyUp to 4 weeks🌎 NA
  • As an anabolic agent per labeled indications: ARCI UCGFS Class 4 Drug. Contraindicated in breeding stallions and food animals.

羊

適応用量経路頻度期間地域
For acute or subacute aflatoxicosis in ruminantsStanozolol 2 mg/kg IM (plus activated charcoal 6.7 mg/kg as a 30% w/v slurry in M/15, pH 7 phosphate buffer).IMSingle dose—🌎 NA
  • For acute or subacute aflatoxicosis in ruminants: Do not combine with oxytetracycline therapy.

ヤギ

適応用量経路頻度期間地域
For acute or subacute aflatoxicosis in ruminantsStanozolol 2 mg/kg IM (plus activated charcoal 6.7 mg/kg as a 30% w/v slurry in M/15, pH 7 phosphate buffer).IMSingle dose—🌎 NA
  • For acute or subacute aflatoxicosis in ruminants: Do not combine with oxytetracycline therapy.

用量は獣医専門家向けの臨床参考資料です。必ず最新の医薬品情報および個別症例に基づいて確認してください。

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概要

​スタノゾロール​は、テストステロンから派生した合成​アナボリックステロイド（AAS）​です。歴史的に獣医学において、食欲増進、体重増加の促進、体力と活力の向上、および慢性疾患に伴う貧血の治療に広く使用されてきました。

米国ではFDA承認の市販製品（Winstrol®-Vなど）はすでに販売されていませんが、獣医用調剤薬局を通じて入手可能です。

​臨床上の注意点:​ スタノゾロールは猫において​肝毒性​の発生率が非常に高いことで知られています。絶対に必要な場合を除き、猫への使用は強く推奨されず、使用する場合は極めて慎重な投与と厳密なモニタリングが必要です。

内因性テストステロンと比較して同化作用/男性化作用の比率が高いものの、特に長期使用や高用量では男性化の副作用（行動の変化や生殖機能の抑制など）が生じる可能性があります。人間による乱用の可能性があるため、​規制薬物​に指定されています。

作用機序

Stanozolol is highly lipophilic and diffuses across the cell membrane to bind with intracellular androgen receptors.

  • ​Anabolic Pathway:​ The receptor-hormone complex translocates to the nucleus → binds to specific DNA sequences (hormone response elements) → modulates transcription of target genes → increases protein synthesis (anabolism), promotes a positive nitrogen balance, and induces muscle hypertrophy.
  • ​Erythropoietic Pathway:​ Stimulates the production of erythropoietin in the kidneys → stimulates bone marrow → increases red blood cell production (useful in treating anemia of chronic disease).
  • ​Fibrinolytic Pathway:​ Enhances fibrinolysis after parenteral injection, which provides a theoretical basis for its use in treating feline aortic thromboembolism or thrombosis in nephrotic syndrome.

安全性・警告

禁忌

  • Pregnant animals (Category X - teratogenic)
  • Breeding stallions
  • Food-producing animals
  • Patients with hepatic dysfunction
  • Patients with hypercalcemia
  • Patients with a history of myocardial infarction
  • Patients with pituitary insufficiency
  • Patients with prostate carcinoma or benign prostatic hypertrophy
  • Patients with mammary carcinoma
  • During the nephrotic stage of nephritis

有害事象

  • Hepatotoxicity (especially high incidence in cats)
  • Sodium, calcium, potassium, water, chloride, and phosphate retention
  • Behavioral changes (androgenic effects such as increased aggression)
  • Reproductive abnormalities (oligospermia, estrus suppression)
  • Mild androgenic effects (usually only at high doses or prolonged use)

注意事項

​Extreme Caution:​ Use in cats due to a very high incidence of hepatotoxicity.

​Caution:​ Use cautiously in patients with cardiac and renal dysfunction; enhanced fluid and electrolyte monitoring is required due to the potential for sodium and water retention.

​Pregnancy Warning:​ FDA Category X / Papich Class D. Teratogenicity clearly outweighs any possible benefit. Contraindicated in pregnant animals. Use with extreme caution in nursing patients as it is unknown if it is excreted in maternal milk.

医薬品相互作用

Anticoagulants (heparin, warfarin)

Anabolic agents may potentiate the effects of anticoagulants; monitoring of INR/PT and dosage adjustment of the anticoagulant are recommended.

Corticosteroids

Anabolics may enhance the edema that can be associated with ACTH or adrenal steroid therapy.

Insulin

Anabolics may decrease blood glucose and decrease insulin requirements; diabetic patients receiving insulin may need dosage adjustments.

監視

  • Androgenic side effects (behavioral changes)
  • Fluid and electrolyte status (especially in cardiac/renal patients)
  • Liver function tests (crucial in cats)
  • RBC count and indices (if treating anemia)
  • Weight and appetite

薬物動態

消失

No specific information located. Injectable suspension is generally dosed on a weekly basis.

過剰投与

No specific information was located for this agent in veterinary species. In humans, sodium and water retention can occur after overdosage of anabolic steroids.

​Treatment:​ Treat supportively and monitor liver function should an inadvertent overdose be administered.

製品

製剤

  • Tablets
  • Injectable suspension

動物用医薬品

  • None commercially available. Previously available as Winstrol®-V tablets and injection. Currently available via compounding pharmacies.

ヒト用医薬品

  • None commercially available.

規制ステータス

規制データなし: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU

保管・安定性

Stanozolol tablets should be stored in tight, light-resistant packaging, preferably at room temperature.

飼主向け情報

スタノゾロールは、ペットの体重増加、筋肉増強、または特定の種類の貧血の治療を助けるために使用されるアナボリックステロイドです。

  • ​投与方法:​ 錠剤は砕いて食事に混ぜて与えることができ、投薬を容易にすることができます。
  • ​安全上の警告:​ この薬は、特に猫において重篤な肝障害を引き起こす可能性があります。獣医師は肝機能を監視するために定期的な血液検査を推奨する場合があります。
  • ​保管と取り扱い:​ 人間による乱用の可能性があるため、スタノゾロールは​規制薬物​です。子供や許可されていない人の手の届かない安全な場所に厳重に保管する必要があります。
  • ​副作用:​ 体液貯留（むくみ）、行動の変化（攻撃性の増加など）、または目や歯茎の黄色化（黄疸）の兆候がないか注意深く観察し、発見した場合は直ちに獣医師に報告してください。

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