テルビナフィン

動物種別の用量

投与経路

禁忌

• Known hypersensitivity to terbinafine
• Active or chronic liver disease
• Significantly impaired renal function
• Perforated eardrum (for ear gel administration)
• Generalized demodicosis (topical or systemic use)
• Pregnant animals
• Breeding animals

有害事象

• Vomiting
• Inappetence
• Diarrhea
• Lethargy (reported in cats)
• Hepatotoxicity / Liver failure (very rare, reported in humans)
• Neutropenia (very rare, reported in humans)
• Serious skin reactions like Toxic Epidermal Necrolysis or Stevens-Johnson syndrome (very rare, reported in humans)
• Diarrhoea
• Increased liver enzymes
• Pruritus (cats)
• Topical irritation (due to alcohol content in topical solutions)
• Transient deafness or impaired hearing (in elderly dogs after administration of ear gel)

薬物相互作用

• Cyclosporine · Terbinafine may increase the elimination and decrease the efficacy of cyclosporine.
• Rifampin · May increase terbinafine clearance, potentially requiring higher terbinafine doses. · moderate
• Beta-blockers · Terbinafine shares the CYP2D6 metabolic pathway and could theoretically alter the metabolism of beta-blockers.
• MAO Inhibitors (e.g., amitraz, selegiline) · Terbinafine shares the CYP2D6 metabolic pathway and could theoretically alter the metabolism of MAOIs.
• SSRIs (e.g., fluoxetine) · Terbinafine shares the CYP2D6 metabolic pathway and could theoretically alter the metabolism of SSRIs.
• Tricyclic Antidepressants · Terbinafine shares the CYP2D6 metabolic pathway and could theoretically alter the metabolism of TCAs.
• Cimetidine · May decrease the clearance of terbinafine, potentially increasing plasma concentrations (Clinical Pearl) · moderate

モニタリング

• Clinical efficacy (resolution of fungal lesions)
• Baseline liver enzymes prior to therapy
• Periodic liver enzyme monitoring as needed, especially during long-term treatment
• CBC (baseline and periodic)
• Liver function tests (ALT, AST, Bilirubin)
• Renal function tests
• Clinical response (skin scrapings, fungal cultures)

過量投与

There is limited information regarding acute toxicity in veterinary species. In humans, acute ingestions of up to 5 grams have been reported without serious adverse effects. Treatment of massive overdose should be supportive and symptomatic.