チロトロピン (甲状腺刺激ホルモン)

動物種別の用量

用量は獣医療従事者向けの臨床リファレンスです。必ず最新の添付文書と個々の患者で確認してください。

投与経路

禁忌

• Adrenocortical insufficiency (untreated Addison's disease)
• Hyperthyroidism
• Coronary thrombosis
• Hypersensitivity to bovine thyrotropin or human proteins
• Repeated administration is not advisable
• Patients currently receiving levothyroxine therapy
• Use of chemical grade TSH (due to anaphylaxis risk)

有害事象

• Hypersensitivity reactions (especially with repeated injections of human-derived proteins in animals)
• Clinical signs of hyperthyroidism (with chronic administration or high doses)
• Anaphylactic responses (specifically associated with chemical grade/bovine TSH; recombinant forms are generally well tolerated)

薬物相互作用

• Anabolic or androgenic steroids · May decrease serum T4 levels, making the TSH stimulation test hard to interpret · moderate
• Carbimazole · May decrease serum T4 levels, making the TSH stimulation test hard to interpret · moderate
• Barbiturates · May decrease serum T4 levels, making the TSH stimulation test hard to interpret · moderate
• Corticosteroids · May decrease serum T4 levels, making the TSH stimulation test hard to interpret · moderate
• Diazepam · May decrease serum T4 levels, making the TSH stimulation test hard to interpret · moderate
• Heparin · May decrease serum T4 levels, making the TSH stimulation test hard to interpret · moderate
• Mitotane · May decrease serum T4 levels, making the TSH stimulation test hard to interpret · moderate
• Phenylbutazone · May decrease serum T4 levels, making the TSH stimulation test hard to interpret · moderate
• Phenytoin · May decrease serum T4 levels, making the TSH stimulation test hard to interpret · moderate
• Salicylates · May decrease serum T4 levels, making the TSH stimulation test hard to interpret · moderate
• Fluorouracil · May cause T4 levels to be increased, making the TSH stimulation test hard to interpret · moderate
• Insulin · May cause T4 levels to be increased, making the TSH stimulation test hard to interpret · moderate

モニタリング

• Serum total T4 concentrations (baseline and 4-6 hours post-administration)
• Clinical signs of hypersensitivity or anaphylaxis during and immediately after administration
• Serum total T4 levels (baseline and post-stimulation, typically 4-6 hours post-injection)

過量投与

Chronic administration at high dosages can produce clinical signs of **hyperthyroidism** (e.g., weight loss, polyphagia, tachycardia, hyperactivity). Massive overdoses can cause clinical signs resembling **thyroid storm** (a life-threatening hypermetabolic state). Treatment is generally supportive and symptomatic; refer to levothyroxine overdose protocols for specific management strategies.