ビタミンE / セレン

Vitamin E / Selenium

Alpha-tocopherol / Sodium selenite

別名: Emulsivit E-300 · Vital E-300 · Equ-SeE · Equ-Se5E · Mu-Se · Bo-Se · L-Se · E-Se · Seletoc · Aquasol E · Nutr-E-Sol · Alpha-tocopherol · Sodium selenite

VetSheet 獣医チームが監修更新日 2026年4月5日エビデンスに基づく獣医学リファレンス

10-15 Units/kg per day PO as alpha-tocopherol acetatePO· q24h

体重— 🐕

用量は獣医専門家向けの臨床参考資料です。必ず最新の医薬品情報および個別症例に基づいて確認してください。

動物種別用量

🌎 NA — North America🌍 EU — Europe

犬

適応	用量	経路	頻度	期間	地域
Adjunctive treatment of discoid lupus erythematosus, canine demodicosis or acanthosis nigricans	200-400 Units PO three times daily	PO	q8h	—	🌎 NA
Adjunctive treatment of cholestatic hepatopathies; necroinflammatory hepatopathies	10-15 Units/kg per day PO as alpha-tocopherol acetate	PO	q24h	—	🌎 NA
Adjunctive treatment of copper-associated hepatopathy	400-600 Units PO per day	PO	q24h	—	🌎 NA
Treatment of tocopherol deficiency associated with exocrine pancreatic disease	100-400 Units PO once daily for one month then every 1-2 weeks as needed	PO	q24h	1 month, then q1-2 weeks	🌎 NA
Vitamin E/Selenium deficiency (using Seletoc)	Initially, 1 mL per 20 pounds of body weight (minimum 0.25 mL; maximum 5 mL) SC, or IM in divided doses in 2 or more sites. Repeat dose at 3 day intervals until satisfactory results then switch to maintenance dose. Maintenance dose: 1 mL per 40 lbs body weight (minimum 0.25 mL) repeat at 3-7 day intervals (or longer) to maintain.	SC/IM	q3d initially, then q3-7d	—	🌎 NA

Adjunctive treatment of discoid lupus erythematosus, canine demodicosis or acanthosis nigricans: Variable efficacy, but relatively innocuous at these dosages
Vitamin E/Selenium deficiency (using Seletoc): If no response in 14 days reevaluate.

猫

適応	用量	経路	頻度	期間	地域
Treatment of tocopherol deficiency associated with exocrine pancreatic disease	30 Units PO once daily for one month then every 1-2 weeks as needed	PO	q24h	1 month, then q1-2 weeks	🌎 NA
Adjunctive treatment of hepatic lipidosis	10 Units/kg once PO once daily	PO	q24h	—	🌎 NA

馬

適応	用量	経路	頻度	期間	地域
Adjunctive treatment of ionophore (monensin) toxicity	4-12 Units/kg PO once daily	PO	q24h	—	🌎 NA
Adjunctive therapy for EPM	8000-9000 Units PO per day	PO	q24h	—	🌎 NA
Adjunctive therapy for metabolic syndrome	10,000 Units PO once daily	PO	q24h	—	🌎 NA
Adjunctive treatment of perinatal asphyxia syndrome (hypoxic ischemic encephalopathy)	Foals: 4,000 Units PO once daily; Mares: 10,000 Units PO once daily	PO	q24h	—	🌎 NA
Vitamin E/Selenium deficiency (using E-Se)	1 mL/100 lbs. body weight slow IV or deep IM (in 2 or more sites; gluteal or cervical muscles). May be repeated at 5-10 day intervals.	IV/IM	q5-10d	—	🌎 NA

Vitamin E/Selenium deficiency (using E-Se): Give slowly when administering IV.

牛

適応	用量	経路	頻度	期間	地域
Vitamin E/Selenium deficiency (using Mu-Se)	For weanling calves: 1 mL per 200 lbs. body weight IM or SC. For breeding beef cows: 1 mL per 200 lbs. body weight during middle third of pregnancy and 30 days before calving IM or SC.	IM/SC	Variable	—	🌎 NA
Vitamin E/Selenium deficiency (using Bo-Se)	Calves: 2.5-3.75 mL/100 lbs body weight (depending on severity of condition and geographical area) IM or SC.	IM/SC	Single dose	—	🌎 NA

Vitamin E/Selenium deficiency (using Mu-Se): Slaughter withdrawal = 30 days.
Vitamin E/Selenium deficiency (using Bo-Se): Slaughter withdrawal = 30 days.

豚

適応	用量	経路	頻度	期間	地域
Vitamin E/Selenium deficiency (using Bo-Se)	Sows and weanling pigs: 1mL/40 lbs. body weight IM or SC (1 mL minimum).	IM/SC	Single dose	—	🌎 NA
Vitamin E/Selenium deficiency (using L-Se)	Baby Pigs: 1 mL SC or IM.	SC/IM	Single dose	—	🌎 NA

Vitamin E/Selenium deficiency (using Bo-Se): Do not use on newborn pigs. Slaughter withdrawal = 14 days.
Vitamin E/Selenium deficiency (using L-Se): Slaughter withdrawal = 14 days.

羊

適応	用量	経路	頻度	期間	地域
Vitamin E/Selenium deficiency (using Bo-Se)	Lambs (2 weeks of age or older): 1 mL per 40 lbs. body weight IM or SC (1 mL minimum). Ewes: 2.5 mL/100 lbs. body weight IM or SC.	IM/SC	Single dose	—	🌎 NA
Vitamin E/Selenium deficiency (using L-Se)	Lambs: 1 mL SC or IM in newborns and 4 mL SC or IM in lambs 2 weeks of age or older	SC/IM	Single dose	—	🌎 NA

Vitamin E/Selenium deficiency (using Bo-Se): Slaughter withdrawal = 14 days.
Vitamin E/Selenium deficiency (using L-Se): Slaughter withdrawal = 14 days.

用量は獣医専門家向けの臨床参考資料です。必ず最新の医薬品情報および個別症例に基づいて確認してください。

診察中ですか？VetSheet の AI が薬剤・用量・投与期間を構造化された診察記録に直接記入します。VetSheet の仕組みを見る

概要

ビタミンEとセレンは、相乗的な抗酸化特性を持つため頻繁に併用されますが、ビタミンE単独でもサプリメントとして広く使用されています。

ビタミンE（α-トコフェロール） は、細胞膜を酸化損傷から保護するために不可欠な脂溶性ビタミンです。円板状エリテマトーデス、毛包虫症などの皮膚疾患、肝疾患、神経疾患の補助療法として使用されます。
セレン は、抗酸化酵素の重要な補因子として機能する微量ミネラルです。配合剤は主に、家畜の白筋病などのセレン・トコフェロール欠乏症（STD）の治療または予防に適応されます。

臨床のポイント： ビタミンEの安全域は広いですが、セレンの過剰摂取は非常に毒性が高いです。配合剤はセレン濃度に基づいて慎重に投与量を決定し、FDAに承認された動物種にのみ使用する必要があります。

作用機序

Both Vitamin E and Selenium are intricately involved in the cellular metabolism of sulfur and the prevention of oxidative stress.

Vitamin E acts as a potent biological free radical scavenger. It prevents the oxidation of polyunsaturated fatty acids within cellular and subcellular membranes.
Selenium is an essential structural component of the enzyme glutathione peroxidase → this enzyme catalyzes the reduction of lipid hydroperoxides to their corresponding alcohols, neutralizing their potential to cause cellular damage.

Together, they protect against red blood cell hemolysis and prevent the destructive action of peroxidase on unsaturated bonds in cell membranes.

安全性・警告

禁忌

Use of combination products in non-FDA approved species
Use of Bo-Se in newborn pigs

有害事象

Anaphylactoid reactions
Transient muscle soreness at injection sites (IM)
Selenium toxicity (depression, ataxia, dyspnea, blindness, diarrhea, muscle weakness, garlic breath)

注意事項

Vitamin E/selenium products should only be used in the species for which they are FDA-approved. Because selenium can be extremely toxic, the promiscuous use of these products cannot be condoned. Give slowly when administering intravenously to horses.

医薬品相互作用

Iron

Large doses of vitamin E may delay the hematologic response to iron therapy in patients with iron deficiency anemia.

Mineral oil

May reduce the absorption of orally administered vitamin E.

Vitamin A

Absorption, utilization, and storage may be enhanced by vitamin E.

Warfarin

Vitamin E may increase the effects of warfarin.

監視

Clinical efficacy
Blood selenium levels (when using combination products)
Glutathione peroxidase activity (optional)

薬物動態

吸収

After absorption, vitamin E is transported in the circulatory system via beta-lipoproteins. Absorption of vitamin E may be impaired in patients with severe cholestatic liver disease or in animals with fat malabsorption syndromes.

分布

Vitamin E is distributed to all tissues and stored in adipose tissue. It is only marginally transported across the placenta.

代謝

Vitamin E is metabolized in the liver.

消失

Vitamin E is excreted primarily into the bile.

過剰投与

Selenium is quite toxic in overdose quantities, but has a fairly wide safety margin. Cattle have tolerated chronic doses of 0.6 mg/kg/day with no adverse effects (approximate therapeutic dose is 0.06 mg/kg).

Clinical signs of selenium toxicity include:

Depression, ataxia, dyspnea, blindness, diarrhea, muscle weakness
A distinct 'garlic' odor on the breath
Horses: May become blind, paralyzed, slough their hooves, and lose hair from the tail and mane.
Dogs: May exhibit anorexia, vomiting, and diarrhea at high dosages.

Large overdoses of vitamin E alone can cause coagulopathies.

製品

製剤

Injection
Oral powder
Oral liquid
Tablets
Capsules

動物用医薬品

Vitamin E Injection: 300 mg/mL (Emulsivit E-300, Vital E-300)
Vitamin E/Selenium Oral: Equ-SeE, Equ-Se5E
Vitamin E/Selenium Injection: Mu-Se (5 mg Se/mL), Bo-Se (1 mg Se/mL), L-Se (0.25 mg Se/mL), E-Se (2.5 mg Se/mL), Seletoc (1 mg Se/mL)

ヒト用医薬品

Vitamin E Tablets: 100 Units, 200 Units, 400 Units, 500 Units & 800 Units
Vitamin E Capsules: 100 Units, 200 Units, 400 Units & 1000 Units
Vitamin E Drops: 15 Units/0.3 mL
Vitamin E Liquid: 15 Units/30 mL, 798 Units/30 mL

規制ステータス

規制データなし: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU

保管・安定性

Vitamin E/Selenium for injection should be stored at temperatures less than 25°C (77°F).

飼主向け情報

厳格な用量遵守： 処方された用量を絶対に超えないでください。ビタミンEは比較的安全ですが、セレンの過剰補給は非常に毒性が高いです。
中毒の兆候： ペットの息から「ニンニク」の臭いがする、極度の脱力感、ふらつき、嘔吐、呼吸困難などの症状が見られた場合は、直ちに獣医師に連絡してください。
投与方法： 経口液剤やカプセル剤を投与する場合は、給餌に関する獣医師の指示に従ってください（脂溶性ビタミンの吸収を高めるため、通常は食事と一緒に与えます）。
保管： 誤飲を防ぐため、すべてのサプリメントは子供や動物の手の届かないところに保管してください。

VetSheet医薬品リファレンスは獣医専門家の臨床意思決定支援を目的としており、専門的判断または製造業者の最新医薬品情報の代替にはなりません。