์์ธํธ์ฐ / ์ด์ฐ
**์์ธํธ์ฐ**(์ผ๋ฐ์ ์ผ๋ก 3-5% ํฌ์๋ ํํ์ธ ์์ด๋ก ์๋ ค์ง)์ ์ฃผ๋ก ๋๋๋ฌผ ์์ํ์์ ์ฌ์ฉ๋๋ ์์ฅ๊ด ์ฐ์ฑํ์ ์ ๋๋คใ * **๋ฐ์ถ๋๋ฌผ**: ๋น๋จ๋ฐฑํ ์ง์(์: ์์)๋ก ์ธํ ์๋ชจ๋์ ์ค๋ ์ ๊ตฌ๋ช ์น๋ฃ์ ๋ก ์ฌ์ฉ๋ฉ๋๋คใ * **๋ง**: ๊ฒฐ์ฅ์ pH๋ฅผ ๋ฎ์ถ์ด ์ฅ๊ฒฐ์ ํ์ฑ์ ์๋ฐฉํ๋ ์๋ฐฉ์ ๋ชฉ์ ์ผ๋ก ์ฌ์ฉ๋ฉ๋๋คใ > **์์ ํ**: ํญ์ ๋๋๋ฅผ ํ์ธํ์ญ์์ค! ์ผ๋ฐ ์๋ฃํ์ ์ ์ฆ๋ฅ ํ์ดํธ ์์ด๋ ๋ณดํต 3-5%์ ์์ธํธ์ฐ์ ํจ์ ํ๊ณ ์์ผ๋ฉฐ, ์์ํ์ ์๊ธ ์ํฉ์์ ๊ฐ์ฅ ์์ ํ๊ณ ์ฝ๊ฒ ๊ตฌํ ์ ์๋ ํํ์ ๋๋ค. ๊ณ ๋๋ ํํ(์: ๋น์ด์ฐ)๋ ๋ถ์์ฑ์ด ๋งค์ฐ ๊ฐํ๋ฏ๋ก ์ทจ๊ธ ๋ฐ ํฌ์ ์ ๊ทน๋์ ์ฃผ์๊ฐ ํ์ํฉ๋๋ค.
์์ฉ ๊ธฐ์ : The primary mechanism of action relies on altering the pH of the gastrointestinal tract: * **Ion Trapping (Ruminants)**: Lowers rumen pH โ shifts toxic, un-ionized ammonia (NH3) to the ionized ammonium ion (NH4+) โ **NH4+ cannot easily cross cell membranes**, significantly reducing systemic absorption of toxic ammonia into the bloodstream. * **Enzyme Inhibition**: Slows the hydrolysis of urea by rumen microbes. * **Mineral Solubility (Horses)**: Lowering the colonic pH increases the solubility of minerals (such as magnesium and phosphorus), preventing them from precipitating and forming **enteroliths**.
๋๋ฌผ ์ข ๋ณ ์ฉ๋
- Treatment of urea poisoning ยท Infuse 5% acetic acid (vinegar) into rumen; may be repeated as necessary if clinical signs reoccur ยท Intraruminal ยท As needed ยท Dose volume not explicitly specified for sheep in monograph, but indicated for ruminants generally.
- Treatment of urea poisoning ยท Infuse 5% acetic acid (vinegar) into rumen; may be repeated as necessary if clinical signs reoccur ยท Intraruminal ยท As needed ยท Dose volume not explicitly specified for goats in monograph, but indicated for ruminants generally.
- Putrefaction of rumen associated with a high rumen pH ยท 4-10 liters of vinegar ยท PO/Intraruminal ยท Once
- Treatment of urea poisoning ยท 2-6 liters into rumen ยท Intraruminal ยท may be repeated as necessary if clinical signs reoccur ยท Using 5% acetic acid (vinegar). Recovery ranges from 8-24 hours. A post-recovery pro-biotic rumen inoculation may enhance the gain and productivity of urea poisoned animals.
- Enterolith prevention ยท 250 mL/450 kg body weight PO ยท PO ยท once daily ยท Using vinegar.
์ฉ๋์ ๋ฉดํ ์์ ์ ๋ฌธ๊ฐ๋ฅผ ์ํ ์์ ์ฐธ๊ณ ์๋ฃ์ ๋๋ค. ํญ์ ์ต์ ๋ผ๋ฒจ๊ณผ ๊ฐ๋ณ ํ์์ ๋ํด ํ์ธํ์ญ์์ค.
ํฌ์ฌ ๊ฒฝ๋ก
๊ธ๊ธฐ
- Potential lactic acidosis (grain overload, rumen acidosis)
์ด์๋ฐ์
- Mucous membrane irritation
- Unpleasant taste
์ฝ๋ฌผ ์ํธ์์ฉ
- Oral medications ยท Due to its acidic qualities, it could potentially affect the degradation or absorption of several drugs in the gut.
๋ชจ๋ํฐ๋ง
- Rumen pH
- Clinical signs of ammonia toxicosis (e.g., tremors, tachypnea, convulsions)
- Resolution of clinical signs
๊ณผ์ฉ๋
When used for appropriate indications, there is little likelihood of serious toxicity occurring after minor overdoses. Due to its potential corrosiveness, the greatest concern would occur if a concentrated form of acetic acid (e.g., glacial acetic acid) was mistakenly used instead of a diluted form (3-5%).
VetSheet ์ฝ๋ฌผ ๋ ํผ๋ฐ์ค๋ ๋ฉดํ ์์ ์ ๋ฌธ๊ฐ๋ฅผ ์ํ ์์ ์์ฌ๊ฒฐ์ ๋ณด์กฐ ๋๊ตฌ์ด๋ฉฐ, ์ ๋ฌธ์ ํ๋จ์ด๋ ์ ์กฐ์ฌ์ ์ต์ ๋ผ๋ฒจ์ ๋์ ํ์ง ์์ต๋๋ค.