아세토히드록삼산

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Cats (highly toxic)
• Patients with poor renal function (e.g., serum creatinine >2.5 mg/dL)
• Pregnancy (FDA Category X - severe teratogenic effects)

이상반응

• Anorexia
• Vomiting
• Mouth and esophageal ulcers
• Hemolytic anemia
• Hyperbilirubinemia
• Bilirubinuria
• CNS disturbances (anxiety, depression, tremulousness)
• Reticulocytosis
• Bone marrow depression
• Phlebitis
• Skin rashes and alopecia

약물 상호작용

• Iron salts · AHA may chelate iron salts in the gut if given concomitantly, reducing absorption.
• Methenamine · AHA may have a synergistic effect with methenamine in inhibiting urine pH increases caused by urease-producing Proteus spp., and may potentiate antibacterial effects.
• Alcohol · In humans, concurrent use of AHA with alcohol has resulted in skin rashes.

모니터링

• CBC (Complete Blood Count)
• Renal function (including urinalysis)
• Hepatic function (specifically bilirubin levels)

과용량

Acute overdoses can lead to severe hematologic and neurologic signs. * **Clinical Signs**: Anorexia, tremors, lethargy, vomiting, and anxiety. * **Hematologic Effects**: Increased reticulocyte counts and severe **hemolytic reactions**. Mild overdoses over several weeks can also result in hemolysis, particularly in patients with reduced renal function. * **Treatment**: Intensive hematologic monitoring with adjunctive supportive therapy, including possible blood transfusions.