아시트레틴

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Pregnancy (absolute contraindication)
• Cardiovascular disease
• Hypertriglyceridemia
• Known sensitivity to acitretin or other retinoids

이상반응

• Anorexia
• Vomiting
• Diarrhea
• Cracking of foot pads
• Pruritus
• Ventral abdominal erythema
• Polydipsia
• Lassitude
• Joint pain/stiffness
• Eyelid abnormalities
• Keratoconjunctivitis sicca (KCS)
• Swollen tongue
• Behavioral changes
• Weight loss (especially in cats)

약물 상호작용

• Alcohol · Acitretin can form etretinate in the presence of alcohol; etretinate is a teratogen with an extremely long terminal half-life that can persist in adipose tissue for years.
• Hepatotoxic drugs (e.g., methotrexate, ketoconazole, sulfonamides, fluconazole, macrolides) · May increase the potential for hepatotoxicity.
• Other retinoids (isotretinoin, tretinoin, vitamin A) · May cause additive toxic effects.
• Tetracyclines · May increase the potential for the occurrence of pseudotumor cerebri (cerebral edema and increased CSF pressure).

모니터링

• Clinical efficacy
• Liver function tests (baseline and if clinical signs appear)
• Schirmer tear tests (monthly, especially in older dogs)
• Serum triglycerides and cholesterol (recommended based on human data)

과용량

Information on overdoses with this agent remains limited. One oral overdose (525 mg) in a human patient resulted only in vomiting. The oral LD50 in rats and mice is >4 grams/kg.