์ํญ์๋ผ๋
์ํญ์๋ผ๋๋ ์ด์์ฌ์กธ๋ฆฐ๊ณ ๊ตฌ์ถฉ์ ๋ก, ์ฃผ๋ก ๋ฐ๋ ค๊ฒฌ์ ๋ฒผ๋ฃฉ ๋ฐ ์ง๋๊ธฐ ๊ฐ์ผ ์น๋ฃ ๋ฐ ์๋ฐฉ์ ์ฌ์ฉ๋ฉ๋๋ค. ๋จ์ผ์ ๋๋ ๋ฐ๋ฒ ๋ง์ด์ ์ฅ์ฌ๊ณผ์ ๋ณตํฉ์ ๋ก ์ ๊ณต๋ฉ๋๋ค.
์์ฉ ๊ธฐ์ : Afoxolaner acts at **ligand-gated chloride channels**, in particular those gated by the inhibitory neurotransmitter **GABA** (gamma-aminobutyric acid). By binding to these channels, it blocks the pre- and post-synaptic transfer of chloride ions across cell membranes โ leading to uncontrolled central nervous system activity โ hyperexcitation โ death of the insect or acarine parasite.
๋๋ฌผ ์ข ๋ณ ์ฉ๋
- Parasite control (fleas, ticks) ยท 11.3 mg, 28.3 mg, 68 mg, or 136 mg tablets ยท PO ยท Not specified in monograph ยท Not specified ยท Administer appropriate tablet size based on weight. Available alone (Nexgard) or with milbemycin oxime (Nexgard Spectra).
์ฉ๋์ ๋ฉดํ ์์ ์ ๋ฌธ๊ฐ๋ฅผ ์ํ ์์ ์ฐธ๊ณ ์๋ฃ์ ๋๋ค. ํญ์ ์ต์ ๋ผ๋ฒจ๊ณผ ๊ฐ๋ณ ํ์์ ๋ํด ํ์ธํ์ญ์์ค.
ํฌ์ฌ ๊ฒฝ๋ก
๊ธ๊ธฐ
- Known hypersensitivity to afoxolaner or any excipients
์ด์๋ฐ์
- Vomiting
- Diarrhea
- Lethargy
- Anorexia
- Neurological signs (tremors, ataxia, seizures) - rare
๋ชจ๋ํฐ๋ง
- Efficacy of parasite control
- Adverse gastrointestinal or neurological signs
๊ณผ์ฉ๋
Afoxolaner is generally well tolerated at multiples of the recommended dose. However, significant overdosage may increase the risk of adverse effects, particularly gastrointestinal upset (vomiting, diarrhea) and neurological signs (tremors, ataxia, seizures). Treatment is symptomatic and supportive as there is no specific antidote.
VetSheet ์ฝ๋ฌผ ๋ ํผ๋ฐ์ค๋ ๋ฉดํ ์์ ์ ๋ฌธ๊ฐ๋ฅผ ์ํ ์์ ์์ฌ๊ฒฐ์ ๋ณด์กฐ ๋๊ตฌ์ด๋ฉฐ, ์ ๋ฌธ์ ํ๋จ์ด๋ ์ ์กฐ์ฌ์ ์ต์ ๋ผ๋ฒจ์ ๋์ ํ์ง ์์ต๋๋ค.