강아지 임신중절약 (아글레프리스톤)

프로게스테론 수용체 길항제

아글레프리스톤은 **프로게스테론 수용체 길항제**로 작용하는 합성 스테로이드입니다. 주로 수의학에서 개와 고양이의 **임신 중절**, 그리고 **자근축농증**과 고양이의 **섬유선종성 유선 증식증**의 내과적 치료에 사용됩니다. 오일-알코올 기반 제제이므로 국소적인 주사 부위 반응이 흔하게 발생합니다. **임상 요점**: 경쟁적 길항제로서 아글레프리스톤은 체내 프로게스테론 수치를 낮추지 않고, 수용체 수준에서 직접 생물학적 작용을 차단합니다.

작용 기전: Aglepristone competitively binds to **progesterone (P4) receptors** in the uterus and other target tissues. * In dogs, its affinity for uterine progesterone receptors is ~3x that of endogenous progesterone; in queens, it is ~9x greater. * **Pathway**: Aglepristone binding → blockade of progesterone signaling → withdrawal of pregnancy support → cervical dilation and resumption of myometrial contractility → fetal resorption or abortion (usually within 7 days). * It also binds to **glucocorticoid receptors** acting as an antagonist, which can block endogenous or exogenously administered glucocorticoids from acting at these sites.

동물 종별 용량

Dogs

To terminate pregnancy (up to day 45) · 10 mg/kg (0.33 mL/kg) subcutaneous injection only. Repeat one time, 24 hours after the first injection. · SC · q24h · 2 doses · A maximum of 5 mL should be injected at any one site. Light massage of the injection site is recommended.
To induce parturition · At day 60 (post-estimated LH surge): 15 mg/kg SC and another dose 24 hours later. Subsequently, give oxytocin 0.15 Units/kg SC at hourly intervals until last pup is delivered. · SC · q24h · 2 doses · Additional studies confirming efficacy and safety are warranted before routine clinical application.
To induce parturition · On or after day 58 of pregnancy: 15 mg/kg subcutaneously; repeat in 9 hours. · SC · Repeat in 9 hours · 2 doses · Expulsion of first pup occurred between 32 and 56 hours after treatment. Use standard protocols to assist with birth.
As an adjunct to treating pyometra/metritis (preserve fertility) · Treatment begun at week 2-4 of diestrus with a single SC injection of aglepristone at 10 mg/kg. Doses are repeated at days 2, 7, and 14. · SC · Days 1, 2, 7, 14 · 14 days · During first 7 days, daily injections of amoxicillin/clavulanic acid were also given.
For closed cervix pyometra · 6 mg/kg twice daily on the first day followed by the same dose once daily on days 2, 3, and 4. Some prefer using larger doses (10mg/kg) once daily on days 1, 3, and 8, then follow up also on days 15 and 28 depending on the bitch's condition. · SC · Variable · Variable
For metritis · 10 mg/kg subcutaneously once daily on days 1, 2 and 8. · SC · Days 1, 2, 8 · 8 days
For open or closed pyometra · aglepristone 10 mg/kg subcutaneously once daily on days 1, 2 and 8 and cloprostenol 1 microgram/kg subcutaneously on days 3 to 7. · SC · Days 1, 2, 8 · 8 days · Bitches with closed pyometra or with elevated temperature/dehydration should also receive IV fluids and antibiotics. If unresolved, additional doses on days 14 and 28.

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

Known hypersensitivity to aglepristone
Pregnancy (unless used specifically for pregnancy termination or inducing parturition)
Hypoadrenocorticism (Addison's disease) or genetic predisposition to it
Peritonitis (must be ruled out before using for pyometra)
Caution in patients with poor health, diabetes, or impaired hepatic/renal function

이상반응

Injection site reactions (pain, edema, skin thickening, ulceration, localized lymph node enlargement)
Anorexia (25%)
Excitation (23%)
Depression (21%)
Diarrhea (13%)
Uterine infections (3.4%)
Vomiting (2%)
Brown mucoid vaginal discharge (associated with pregnancy termination)
Mammary gland congestion

약물 상호작용

Progestins (natural or synthetic) · Could reduce the efficacy of aglepristone
Glucocorticoids · Aglepristone could reduce the efficacy of glucocorticoid treatment due to receptor antagonism · moderate
Ketoconazole · May interact with aglepristone (manufacturer warning, likely due to CYP450 enzyme inhibition)
Itraconazole · May interact with aglepristone (manufacturer warning)
Erythromycin · May interact with aglepristone (manufacturer warning)

모니터링

Clinical efficacy
For pregnancy termination: ultrasound 10 days after treatment and at least 30 days after mating
Injection site reactions (pain, swelling, ulceration)
Systemic adverse effects (anorexia, excitation, depression, diarrhea)

과용량

When administered at 3X (30 mg/kg) recommended doses, bitches demonstrated no untoward systemic effects. Localized reactions were noted at the injection site, presumably due to the larger volumes injected.

VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.