μνΈλ λ Έκ²μ€νΈ
μνΈλ λ Έκ²μ€νΈ(Altrenogest)λ μμ λ²μ μνμμ λ리 μ¬μ©λλ ν©μ± κ²½κ΅¬μ© νλ‘κ²μ€ν΄μ λλ€. - **λ§**: μλ§μ λ°μ μ μ΅μ νμ¬ μ£ΌκΈ°λ₯Ό λκΈ°ννκ³ , ν©μ²΄ κΈ°λ₯ λΆμ μ΄λ νλ°μΌμ΄ μλ μλ§μ μμ μ μ μ§νλ λ° μ¬μ©λ©λλ€. - **λΌμ§**: μ±μν λ―Έκ²½μ°λμ λ°μ λκΈ°νμ μ¬μ©λ©λλ€. - **κ°**: ν©μ²΄ κΈ°λ₯ λΆμ λ° μ‘°μ° λ°©μ§λ₯Ό μν μκΆ μμΆ μ΅μ μ λ‘ νκ° μΈ μ¬μ©λ©λλ€. > **μμ μ£Όμμ¬ν**: μ΄ μ½λ¬Όμ μ§μ©μ±μ΄ λμ μμλμ§ μμ μ¬λμ νΌλΆλ₯Ό ν΅ν΄ μ½κ² ν‘μλ©λλ€. μ·¨κΈμ(νΉν μμ°λΆ λ° νμ μμ μ¦μ΄λ μμ€νΈλ‘κ² μμ‘΄μ± μ§ν λ³λ ₯μ΄ μλ μ¬λ)μκ² μ¬κ°ν κ±΄κ° μνμ μ΄λν μ μμ΅λλ€.
μμ© κΈ°μ : Altrenogest acts as an agonist at **progesterone receptors**. - Transforms proliferative endometrium into secretory endometrium. - Enhances myometrial hypertrophy and inhibits spontaneous uterine contractions (tocolytic effect). - Exerts negative feedback on the hypothalamus and pituitary gland β inhibits secretion of **GnRH** β decreases release of pituitary gonadotropins (**FSH** and **LH**), thereby suppressing estrus and ovulation in a dose-dependent manner.
λλ¬Ό μ’ λ³ μ©λ
- To suppress estrus for synchronization Β· 1 mL per 110 pounds body weight (0.044 mg/kg) Β· PO Β· once daily Β· 15 consecutive days Β· May administer directly on tongue using a dose syringe or on the usual grain ration.
- For prevention of abortion/pregnancy loss Β· 0.088 mg/kg Β· PO Β· once daily
- To maintain pregnancy in mares with deficient progesterone levels Β· 0.044 mg/kg Β· PO Β· once daily Β· Until day 60, 120, or end of pregnancy Β· Three options: 1) until day 60+ AND endogenous progesterone >4 ng/mL; 2) until day 120; 3) until end of pregnancy.
- To maintain pregnancy in mares with placentitis Β· 22-44 mg (total dose; 10-20 mL) Β· PO Β· daily
- To suppress estrus (long-term) Β· 0.044 mg/kg Β· PO Β· daily
- For synchronization of estrous in sexually mature gilts that have had at least one estrous cycle Β· 6.8 mL (15 mg) per gilt Β· PO Β· once daily Β· 14 consecutive days Β· Apply as a top-dressing on a portion of gilt's daily feed allowance. Estrous should occur 4-9 days after completing treatment.
- Luteal insufficiency Β· 2 mL per 100 lbs of body weight Β· PO Β· once daily Β· Document luteal insufficiency and rule out infectious causes. Best to avoid during first trimester. Monitor pregnancy with ultrasound. Monitor carefully for pyometra.
- Luteal insufficiency, pre-term labor Β· 0.1 mL per 10 lb body weight Β· PO Β· once daily
μ©λμ λ©΄ν μμ μ λ¬Έκ°λ₯Ό μν μμ μ°Έκ³ μλ£μ λλ€. νμ μ΅μ λΌλ²¨κ³Ό κ°λ³ νμμ λν΄ νμΈνμμμ€.
ν¬μ¬ κ²½λ‘
κΈκΈ°
- Horses intended for food purposes
- Mares with chronic uterine infections
- Manufacturer lists pregnancy as a contraindication (though clinically used extensively to maintain pregnancy)
μ΄μλ°μ
- Minimal at labeled dosages
- Slight, sporadic elevations in Ca++, K+, alkaline phosphatase, and AST
- May exacerbate chronic uterine infections
- Risk of pyometra in dogs (due to exogenous progesterone effects)
μ½λ¬Ό μνΈμμ©
- Rifampin Β· May decrease progestin activity if administered concomitantly due to microsomal enzyme induction and increased progestin metabolism.
λͺ¨λν°λ§
- Pregnancy viability (via ultrasound)
- Endogenous progesterone levels (if treating luteal deficiency)
- Signs of pyometra in dogs
κ³Όμ©λ
The LD50 of altrenogest is 175-177 mg/kg in rats. No specific information is available regarding the effects of an accidental acute overdose in horses or other veterinary species.
VetSheet μ½λ¬Ό λ νΌλ°μ€λ λ©΄ν μμ μ λ¬Έκ°λ₯Ό μν μμ μμ¬κ²°μ 보쑰 λꡬμ΄λ©°, μ λ¬Έμ νλ¨μ΄λ μ μ‘°μ¬μ μ΅μ λΌλ²¨μ λμ νμ§ μμ΅λλ€.