수산화알루미늄

인 결합제 / 제산제

수산화알루미늄은 경구 투여되는 화합물로, 수의학에서는 주로 **만성 신장 질환(CKD)** 환자의 고인산혈증을 관리하기 위한 **장관 내 인 결합제**로 사용됩니다. * 또한 위장관 궤양을 치료하거나 예방하기 위한 **위 제산제**로도 활용됩니다. * > **임상 팁:** 인체용 액상 제산제(예: 민트향 현탁액)를 일반 의약품으로 구할 수 있지만, 개와 고양이는 그 맛을 매우 싫어하는 경우가 많습니다. 조제된 건조 분말은 거의 무맛이므로 캔 사료에 섞어 투여하기가 훨씬 수월합니다.

작용 기전: * **Phosphate Binding:** In the gastrointestinal tract, **aluminum** binds to dietary **phosphate** → forms insoluble **aluminum phosphate** → excreted in the feces. This prevents the systemic absorption of phosphorus, thereby lowering serum phosphorus levels. * **Antacid:** Neutralizes gastric hydrochloric acid → increases gastric pH → reduces pepsin activity, providing a protective effect on the gastric mucosa.

동물 종별 용량

Cats

Hyperphosphatemia · Initially at 30-90 mg/kg per day · PO · divided with meals · Dosage must be individualized. Capsules or suspension are preferred as they are more easily mixed with food and dispersed throughout ingesta.
Hyperphosphatemia · 15-45 mg/kg · PO · q12h
As an antacid · ¼ tablet · PO · q6h · Aluminum hydroxide tablets

Cattle

As an antacid · 30 grams/animal · PO · as needed

Horses

Adjunctive gastroduodenal ulcer therapy in foals · 15 mL (total dose) · PO · 4 times a day · Aluminum/magnesium hydroxide suspension

SmallMammals

General · 1 mL/animal · PO · as needed · Chinchillas; Aluminum hydroxide gel
General · 0.5-1 mL/animal · PO · as needed · Guinea pigs

Dogs

Hyperphosphatemia · 30-100 mg/kg/day · PO · with meals
Hyperphosphatemia · 30-90 mg/kg/day · PO · prior to meals · Aluminum hydroxide gel, dried powder. The dried powder is virtually tasteless and accepted readily by most cats when mixed with canned food.
Hyperphosphatemia · 15-45 mg/kg · PO · q12h
Adjunctive therapy for gastric ulcers · 2-10 mL · PO · q2-4h · Aluminum hydroxide suspension or aluminum hydroxide/magnesium hydroxide suspension
Adjunctive therapy for gastric ulcers · ½-1 tablet or strength · PO · q6h · Aluminum hydroxide tablets

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

Use with caution in patients with delayed gastric emptying or severe constipation
Use with caution in patients with severe renal failure due to risk of aluminum accumulation

이상반응

Constipation
Aluminum toxicity (neuromuscular weakness, microcytosis) with chronic use or severe renal impairment
Hypophosphatemia (if over-supplemented)

약물 상호작용

Isoniazid · Decreased absorption; separate oral doses by two hours
Penicillamine · Decreased absorption; separate oral doses by two hours
Phenothiazines · Decreased absorption; separate oral doses by two hours
Tetracyclines · Decreased absorption; separate oral doses by two hours
Thyroid Hormones · Decreased absorption; separate oral doses by two hours

모니터링

Serum phosphorus (after a 12-hour fast), initially at 10-14 day intervals; once 'stable', at 4-6 week intervals
Neuromuscular effects (signs of aluminum toxicity)
Progressive decreases in mean cell volume (MCV) and microcytosis

과용량

Chronic overdosage or accumulation in patients with severe renal failure can lead to **aluminum toxicity**. * Signs of toxicity include neuromuscular effects (weakness, stumbling, difficulty walking) and hematological changes (progressive decreases in mean cell volume [MCV] and microcytosis).

VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.