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금기

• Hyperkalemia
• Severe renal impairment or anuria
• Addison's disease (hypoadrenocorticism)
• Concurrent use of potassium supplements (unless closely monitored)

이상반응

• Hyperkalemia
• Hyponatremia
• Gastrointestinal disturbances (nausea, vomiting, diarrhea)
• Dehydration
• Weakness or lethargy

약물 상호작용

• ACE Inhibitors (e.g., Enalapril, Benazepril) · Increased risk of severe hyperkalemia due to additive potassium-sparing effects. · major
• Potassium Supplements · Significant risk of hyperkalemia. · major
• NSAIDs · May reduce the diuretic effect of amiloride and increase the risk of nephrotoxicity and hyperkalemia. · moderate
• Spironolactone · Additive potassium-sparing effects leading to hyperkalemia. · major

모니터링

• Serum potassium levels
• Serum sodium levels
• Renal function panel (BUN, Creatinine)
• Hydration status
• Blood pressure

과용량

Overdose primarily presents as **severe hyperkalemia**, **dehydration**, and **hyponatremia**. Clinical signs may include profound weakness, bradycardia, cardiac arrhythmias, and collapse. **Treatment:** Discontinue the drug immediately. Induce emesis or perform gastric lavage if ingestion is recent. Treat hyperkalemia aggressively (e.g., IV fluids, calcium gluconate, dextrose/insulin, or sodium bicarbonate as clinically indicated).