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아미트라즈

Amitraz

N-methylbis(2,4-xylyliminomethyl)amine

항기생충약 / 포름아미딘계topical개고양이소형 포유류

다른 이름: Mitaban · Taktic · Preventic · Aludex · ProMeris (historical) · Amitrazum

VetSheet 수의사 팀 검수업데이트 2026년 4월 5일근거 기반 수의학 참고자료

250 ppm (one 10.6 mL bottle in 2 gallons of warm water)topical· q14d· 3-6 treatments (or until 30 days past two negative skin scrapings)
10.6 ml — 개체당 고정 용량(체중에 따라 환산하지 않음)

용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.

동물 종별 용량

🌎 NA — North America🌍 EU — Europe

개

적응증용량경로빈도기간지역
Generalized demodicosis (Labeled Protocol)250 ppm (one 10.6 mL bottle in 2 gallons of warm water)topicalq14d3-6 treatments (or until 30 days past two negative skin scrapings)🌎 NA
Generalized demodicosis (Extra-label Protocol 1)250 ppm, 500 ppm, or 1000 ppmtopicalq7dUntil 30 days past two negative skin scrapings🌎 NA
Generalized demodicosis (Extra-label Protocol 2)0.125% solution (1 mL of 12.5% Taktic in 100 mL water)topicalq24hUntil 30 days past two negative skin scrapings🌎 NA
Otic demodicosis1 mL of 12.5% Taktic in 8.5 mL mineral oiltopicalq3-7dUntil resolved🌎 NA
Generalized mite infestations (canine demodicosis, sarcoptic acariasis and cheyletiellosis)Diluted as a dip, left on the coattopicalAs directed (typically weekly or bi-weekly depending on specific product label)Until clinical and microscopic resolution🌍 EU
  • Generalized demodicosis (Labeled Protocol): Apply to entire animal and air dry. DO NOT rinse or towel dry.
  • Generalized demodicosis (Extra-label Protocol 1): Step up concentration if lower doses fail. Increased risk of toxicity at higher doses.
  • Generalized demodicosis (Extra-label Protocol 2): Rub onto one-half of the dog's body and alternate sides daily.
  • Otic demodicosis: Discontinue if irritation develops.
  • Generalized mite infestations (canine demodicosis, sarcoptic acariasis and cheyletiellosis): Clipping long-haired coats will improve penetration. Animals should not be bathed or allowed to swim for 48 hours after application.

고양이

적응증용량경로빈도기간지역
Follicular demodicosis (Demodex cati)0.0125% (125 ppm)topicalq7-14dUntil resolved🌎 NA
Surface demodicosis (Demodex gatoi)0.0125% (125 ppm)topicalq7d12 weeks🌎 NA
  • Follicular demodicosis (Demodex cati): Extra-label. Monitor very closely for side effects. Use E-collar until dry.
  • Surface demodicosis (Demodex gatoi): Extra-label. Monitor very closely for side effects. Use E-collar until dry.

소형 포유류

적응증용량경로빈도기간지역
Mite treatment (Mice, Rats, Gerbils, Hamsters, Guinea pigs, Chinchillas)1.4 mL per litertopicalq14d3-6 treatments🌎 NA
  • Mite treatment (Mice, Rats, Gerbils, Hamsters, Guinea pigs, Chinchillas): Not recommended in young animals or rabbits.

용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.

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개요

아미트라즈는 포름아미딘계 살비제 및 살충제로, 수의학에서 주로 개의 전신성 모낭충증 치료 및 벼룩/진드기 구제에 사용됩니다. 고양이와 토끼에게는 매우 독성이 강합니다.

작용 기전

Acts as a monoamine oxidase (MAO) inhibitor in susceptible mites → alters neurotransmitter breakdown → CNS toxicity and death. Additionally, acts as an alpha-2 adrenergic agonist in mammals → inhibits insulin release → transient hyperglycemia and sedation. Also inhibits prostaglandin synthesis.

안전성·주의사항

금기사항

  • Cats and rabbits (highly toxic, though extra-label protocols exist)
  • Chihuahuas and toy breeds (use with extreme caution)
  • Puppies less than 4 months of age
  • Dogs with deep pyodermas and draining tracts (treat infection first)
  • Brittle diabetic patients
  • Pregnant or nursing animals

부작용

  • Transient sedation (up to 72 hours)
  • Ataxia
  • Bradycardia
  • Vomiting and diarrhea
  • Hypothermia
  • Transient hyperglycemia
  • Pruritus, erythema, and edema at application site
  • Seizures (rare)

주의

​Safety Warning:​ Liquid concentrates are flammable until diluted.

  • Clients must wear rubber gloves when mixing and applying.
  • Wash hands and arms thoroughly after application.
  • Do not stress animals for at least 24 hours post-application.
  • Use ophthalmic protectants (e.g., petrolatum ointment) if treating near the eyes.
  • Dispose of unused diluted solution by flushing down the drain and do not reuse containers.

약물 상호작용

Corticosteroids

Immunosuppression can worsen demodicosis; concomitant use is contraindicated.

Selegiline

Concurrent use of MAO inhibitors increases risk of toxicity.

Amitriptyline

Concurrent use with tricyclic antidepressants is not recommended.

Clomipramine

Concurrent use with tricyclic antidepressants is not recommended.

Alpha-2 agonist sedatives (e.g., dexmedetomidine, xylazine)Major

Additive or synergistic CNS depression and cardiovascular effects (bradycardia).

Other ectoparasiticidesModerate

Potential for increased toxicity.

모니터링

  • Resolution of clinical signs (negative skin scrapings)
  • Blood glucose levels (especially in diabetic patients)
  • Heart rate and body temperature
  • Signs of excessive sedation or CNS depression

약동학

흡수

Absorbed systemically through the skin, especially if the skin barrier is compromised.

과다투여

Toxicity can be significant, especially if amitraz-containing collars are ingested.

  • ​Signs:​ Ataxia, severe CNS depression, bradycardia, hypothermia, and marked hyperglycemia.
  • ​Treatment:​ Emesis (if asymptomatic), endoscopic retrieval of ingested collars, activated charcoal, and cathartics.
  • ​Antidotes:​ Yohimbine (0.11-0.2 mg/kg IV) or Atipamezole can effectively reverse the alpha-2 adrenergic mediated signs (sedation, bradycardia, hyperglycemia). Repeated doses may be necessary due to the short half-life of the reversal agents.

제품

제형

  • Solution for Dilution: 19.9%
  • Solution (emulsifiable concentrate) for Dilution: 12.5%
  • Spot-On Solution: amitraz 150 mg/mL; metaflumizone 150 mg/mL
  • Collar: 9% amitraz

동물용의약품

  • Mitaban Solution for Dilution 19.9%
  • Taktic EC Solution 12.5%
  • ProMeris for Dogs Spot-On Solution
  • Preventic Collar 9%

규제 현황

European Union✓ 승인됨처방전의약품EMA
🐕 Dogs🐄 Cattle🐑 Sheep pigs

투여 중단 기간: cattle meat 28 days · pig meat 7 days · sheep meat 28 days

Classified as POM-V in the UK/EU.

United Kingdom✓ 승인됨처방전의약품VMD
🐕 Dogs🐄 Cattle🐑 Sheep pigs

POM-V (Prescription Only Medicine - Veterinarian).

규제 데이터 없음: 🇺🇸 US · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU

보관·안정성

Liquid concentrates are flammable. Store at room temperature away from open flames. Once diluted with water, the solution must be used immediately and cannot be stored for future use.

보호자 정보

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