비타민 C / 아스코르브산

투여 경로

금기

• Patients with a history of urate or calcium oxalate urolithiasis
• Use with caution in patients with iron storage diseases (e.g., hemochromatosis)
• Patients with a history of calcium oxalate or urate urolithiasis (due to urine acidification)

이상반응

• Gastrointestinal upset (diarrhea) with high oral doses
• Pain or tissue irritation at the injection site (IM or SC)
• Increased risk of calcium oxalate urolithiasis with chronic high-dose administration
• Gastrointestinal upset (diarrhea) at high oral doses
• Pain at injection site (IM/SC)
• Potential to acidify urine, which may increase the risk of oxalate or urate urolithiasis

약물 상호작용

• Deferoxamine · Concurrent use may exacerbate tissue iron toxicity, particularly in the heart. · major
• Urine acidifying agents · May have additive acidifying effects, potentially increasing the risk of crystalluria. · moderate

모니터링

• Clinical signs of disease resolution (e.g., improvement of scurvy symptoms in guinea pigs)
• Urine pH (if utilized specifically as a urinary acidifier)
• Resolution of clinical signs of scurvy (in susceptible species)
• Urine pH (if using high doses)

과용량

Ascorbic acid is generally very safe due to its water-soluble nature; excess amounts are rapidly excreted in the urine. Massive acute overdoses may cause **gastrointestinal disturbances** (such as diarrhea) or **mild acidosis**. Chronic overdosage significantly increases the risk of **calcium oxalate urolithiasis**.