오라노핀

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Systemic Lupus Erythematosus (SLE) - may exacerbate signs
• Pregnancy (known teratogen and maternotoxic)

이상반응

• Immune-mediated thrombocytopenia (dose-dependent)
• Hemolytic anemia
• Leukopenia
• Gastrointestinal disturbances (particularly diarrhea, dose-dependent)
• Renal toxicity (proteinuria)
• Hepatotoxicity (increased liver enzymes)
• Dermatosis
• Corneal ulcers

약물 상호작용

• Cytotoxic agents (including high dose corticosteroids) · Safety when used with these agents has not been established; use with caution.
• Penicillamine · Increased potential for hematologic or renal toxicity; use with gold salts is not recommended.
• Antimalarial drugs · Increased potential for hematologic or renal toxicity; use with gold salts is not recommended.

모니터링

• Hepatic function tests (baseline, monthly for 2-3 months, then every other month)
• Renal function tests including urinalysis (baseline, monthly for 2-3 months, then every other month)
• CBC with platelet counts (baseline, monthly for 2-3 months, then every other month). Note: eosinophilia may denote impending reactions.

과용량

Very limited data is available. The minimum lethal oral dose in rats is 30 mg/kg. * **Decontamination**: Gut-emptying protocols should be employed after an acute overdose when applicable. * **Antidotes**: Chelating agents (e.g., penicillamine, dimercaprol) have been used for severe toxicities, but their use is controversial.