오로티오글루코스

투여 경로

금기

• Pre-existing renal disease
• Hepatic dysfunction
• Severe hematologic disorders or pre-existing cytopenias
• Systemic lupus erythematosus (SLE)
• Pregnancy and lactation
• History of severe toxicity to heavy metals

이상반응

• Bone marrow suppression (thrombocytopenia, anemia, leukopenia)
• Nephrotoxicity (proteinuria, glomerulonephritis)
• Hepatotoxicity
• Stomatitis and oral ulcers
• Dermatologic reactions (Toxic epidermal necrolysis, Erythema multiforme)
• Anaphylaxis (rare)

약물 상호작용

• Penicillamine · Increased risk of severe hematologic and renal toxicity.
• Immunosuppressants (e.g., cyclophosphamide, azathioprine) · Synergistic bone marrow suppression; use together with extreme caution.
• Phenylbutazone · Increased risk of blood dyscrasias.

모니터링

• Complete Blood Count (CBC) with platelets (prior to every dose)
• Urinalysis (specifically monitoring for proteinuria prior to every dose)
• Liver enzyme panels
• Renal function panels (BUN, Creatinine)
• Clinical signs of bleeding, bruising, or oral ulcers

과용량

Overdosage can lead to severe heavy metal toxicity. * **Symptoms:** Profound bone marrow suppression (bleeding, severe infections), acute renal failure, and severe gastrointestinal signs. * **Treatment:** Involves immediate discontinuation of the drug, aggressive supportive care, and potential use of heavy metal chelating agents such as **dimercaprol (BAL)** to enhance excretion.