베타메타손

투여 경로

금기

• Suspected corneal abrasion
• Corneal ulceration
• Feline herpes keratitis (FHV-1)

이상반응

• Delayed corneal healing
• Increased intraocular pressure (IOP)
• Potentiation of ocular infections
• Systemic absorption leading to adrenal suppression (rare with topical use but possible in small patients)

약물 상호작용

• NSAIDs · Increased risk of GI ulceration · major
• Insulin · Glucocorticoids antagonize the effect of insulin · major
• Phenobarbital · May accelerate the metabolism of corticosteroids · moderate
• Itraconazole · May decrease the metabolism of corticosteroids · moderate
• Acetazolamide · Increased risk of hypokalaemia · moderate
• Amphotericin · Increased risk of hypokalaemia · moderate
• Furosemide · Increased risk of hypokalaemia · moderate
• Thiazide diuretics · Increased risk of hypokalaemia · moderate

모니터링

• Fluorescein staining (to ensure intact cornea prior to and during use)
• Intraocular pressure (IOP)
• Resolution of clinical signs of inflammation

과용량

Overdose via topical ophthalmic administration is unlikely to cause acute life-threatening signs, but chronic overuse can lead to iatrogenic hyperadrenocorticism (Cushing's syndrome) and local ocular complications (glaucoma, corneal degeneration).