볼데논 운데실레네이트

단백동화 스테로이드

**볼데논 운데실레네이트**는 테스토스테론에서 파생된 장기 지속형 주사용 **단백동화 스테로이드**입니다. 주로 수의학에서 쇠약해진 말의 체중, 털 상태 및 전반적인 신체 상태 개선을 돕기 위해 사용됩니다. 소동물 임상에서는 과거 고양이의 식욕 촉진제로 허가 외 사용(off-label)되기도 했으나, 간독성 위험으로 인해 현재는 더 안전하고 효과적인 대안으로 대체되는 추세입니다. > **임상 요점:** 볼데논은 참기름 기제에 운데실레네이트 에스테르 형태로 조제되어 근육 주사 부위에서의 흡수를 지연시키고 수주에 걸쳐 지속적인 방출을 제공합니다. 근육 강화 특성으로 인해 미국에서는 **스케줄 III (C-III) 통제 약물**로 지정되어 있으며, 인체 남용 및 불법 유통의 위험이 높습니다.

작용 기전: Boldenone works by binding to intracellular **androgen receptors** in muscle and other tissues → the receptor-steroid complex translocates to the nucleus → alters gene transcription → promotes protein synthesis, nitrogen retention, and tissue building (anabolism) while reversing catabolism. * **Erythropoiesis:** Stimulates red blood cell production, likely by increasing the production of **erythropoietic stimulating factor (erythropoietin)**. * **Endocrine Feedback:** High doses cause negative feedback on the hypothalamus and pituitary gland → inhibits **Luteinizing Hormone (LH)** and **Follicle Stimulating Hormone (FSH)** → suppresses endogenous testosterone release and impedes spermatogenesis. * **Electrolyte Balance:** Causes retention of nitrogen, sodium, potassium, and phosphorus, and decreases urinary excretion of calcium.

동물 종별 용량

Cats

As an appetite stimulant · 5 mg (total dose) IM/SC every 7 days · IM/SC · q7d · Anabolic steroids not as effective as many other appetite stimulants and may be associated with hepatotoxicity

Horses

Debilitated horses (improvement in weight, haircoat, or general physical condition) · 1.1 mg/kg IM; may repeat in 3 week intervals · IM · q3w · Most horses will respond with one or two treatments. ARCI UCGFS Class 4 Drug.
Debilitated horses · 1 mg/kg IM; repeated at 3 week intervals · IM · q3w · ARCI UCGFS Class 4 Drug.

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

IMSC

금기

Stallions intended for reproduction
Pregnant mares (Category X - risk of fetal masculinization)
Non-pregnant mares intended for reproduction
Horses intended for food purposes
Patients with hepatic dysfunction
Patients with hypercalcemia
Patients with a history of myocardial infarction
Patients with pituitary insufficiency
Patients with prostate carcinoma or benign prostatic hypertrophy

이상반응

Androgenic effects (over-aggressiveness)
Detrimental effects on testis size and sperm production in males
Altered sexual behavior, shortened estrus, and reduced pregnancy rates in females
Clitoral enlargement in females
Hepatotoxicity
Sodium and water retention

약물 상호작용

Anticoagulants (e.g., warfarin) · Anabolic agents may potentiate the effects of anticoagulants; monitoring of INR and dosage adjustment are recommended.
Corticosteroids / ACTH · May enhance the edema that can be associated with ACTH or adrenal steroid therapy.
Insulin · May decrease blood glucose and decrease insulin requirements; diabetic patients may need dosage adjustments.

모니터링

Androgenic side effects (e.g., aggression, behavioral changes)
Fluid and electrolyte status, if indicated
Liver function tests, if indicated
Red blood cell count and indices, if indicated
Weight and appetite

과용량

Sodium and water retention can occur after overdosage of anabolic steroids. It is suggested to treat supportively and monitor liver function should an inadvertent overdose be administered.

VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.