아세트산 칼슘
Calcium Acetate
Calcium acetate
다른 이름: PhosLo · Calphron · Eliphos · Phosex · calcii acetas · acetato de calcio · kalcio acetates · kalciumacetat · kalciumasetaatti · Calcium diacetate
VetSheet 수의사 팀 검수업데이트 2026년 4월 5일근거 기반 수의학 참고자료
용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.
동물 종별 용량
🌎 NA — North America🌍 EU — Europe
개
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Hyperphosphatemia associated with chronic renal failure | 60-90 mg/kg/day | PO | divided with meals | — | 🌎 NA |
| Hyperphosphatemia in CKD | 60-90 mg/kg/day divided | PO | divided with meals | Long-term | 🌍 EU |
- Hyperphosphatemia associated with chronic renal failure: In conjunction with a low-phosphorus diet. Give with food or mixed with food, or just prior to each meal. Individualize dose to achieve desired serum phosphorus concentrations. Decrease dose if serum calcium exceeds normal limits.
- Hyperphosphatemia in CKD: Dose must be titrated based on serum phosphorus levels. Must be given with food.
고양이
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Hyperphosphatemia associated with chronic renal failure | 60-90 mg/kg/day | PO | divided with meals | — | 🌎 NA |
| Hyperphosphatemia in CKD | 60-90 mg/kg/day divided | PO | divided with meals | Long-term | 🌍 EU |
- Hyperphosphatemia associated with chronic renal failure: In conjunction with a low-phosphorus diet. Give with food or mixed with food, or just prior to each meal. Individualize dose to achieve desired serum phosphorus concentrations. Decrease dose if serum calcium exceeds normal limits.
- Hyperphosphatemia in CKD: Dose must be titrated based on serum phosphorus levels. Must be given with food.
용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.
개요
아세트산 칼슘은 주로 만성 신장 질환(CKD)에 이차적으로 발생하는 고인산혈증 관리에 사용되는 경구용 인 결합제입니다. 탄산칼슘에 비해 인 결합 효율이 높아(원소 칼슘 1g당 약 2배의 인 결합) 의인성 고칼슘혈증의 위험이 낮습니다. 또한 구연산칼슘과 달리 위장관에서 알루미늄 흡수를 촉진하지 않습니다.
작용 기전
When administered with meals, calcium acetate dissociates in the gastrointestinal tract. The calcium ions then bind to dietary phosphorus in the stomach and proximal small intestine to form calcium phosphate, an insoluble complex.
Dietary Phosphorus + Calcium Acetate → Insoluble Calcium Phosphate → Excreted in feces.
This mechanism effectively reduces the gastrointestinal absorption of phosphorus, thereby lowering serum phosphorus levels. It is soluble over a wide range of pH, making it highly available for binding.
안전성·주의사항
금기사항
- Pre-existing hypercalcemia
부작용
- Hypercalcemia
- Gastrointestinal intolerance (nausea)
주의
Warning: Do not use in patients with pre-existing hypercalcemia.
- Ca × P Product: Use with extreme caution if the serum calcium and phosphorus product exceeds 60 due to the risk of metastatic soft tissue mineralization.
- Concurrent Calcitriol: The concurrent use of calcium-based binders and calcitriol is controversial; some consider it contraindicated, while others require intensified monitoring for hypercalcemia.
- Monitoring: Adequate monitoring of serum ionized calcium and phosphorus is strictly required.
약물 상호작용
May lead to hypercalcemia; if used concomitantly, intensified monitoring for hypercalcemia is mandatory.
Not recommended; hypercalcemia induced by calcium acetate may cause serious arrhythmias in patients on digoxin.
Oral calcium can reduce the absorption of fluoroquinolones. Separate dosages by at least two hours.
Oral calcium can reduce the absorption of tetracyclines. Separate dosages by at least two hours.
Decreased absorption of levothyroxine
모니터링
- Serum phosphorus (after a 12-hour fast)
- Serum ionized calcium
- Monitor initially at 10-14 day intervals; once 'stable', at 4-6 week intervals
약동학
흡수
In humans, approximately 30% is absorbed when given with food. No specific pharmacokinetic information is available for dogs and cats.
배설
Unabsorbed calcium and bound calcium phosphate are eliminated in the feces.
과다투여
Acute overdoses could potentially cause hypercalcemia.
- Management: Patients should be monitored and treated symptomatically.
- If the dosage was massive and recent, consider using standard protocols to empty the gut (e.g., emesis induction or gastric lavage, followed by activated charcoal, though charcoal does not bind minerals well).
제품
제형
- Tablets
- Capsules
- Gelcaps
인용의약품
- Calcium Acetate Oral Tablets: 667 mg (169 mg elemental calcium); Calphron® (Nephro-Tech); Eliphos® (Hawthorn)
- Calcium Acetate Oral Capsules & Gelcaps: 667 mg (169 mg elemental calcium); PhosLo® (Fresenius)
규제 현황
Human approved products used off-label
POM (Prescription Only Medicine)
규제 데이터 없음: 🇺🇸 US · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
보관·안정성
Store commercially available tablets, capsules, and gelcaps at room temperature (25°C); excursions are permitted to 15-30°C.
보호자 정보
사료 내 인을 효과적으로 결합하기 위해 반드시 식사와 함께(식사 직전 또는 사료에 섞어서) 투여해야 합니다. 수의사의 특별한 지시가 없는 한 식사 사이에 투여하지 마십시오. 이 약물을 사용하는 동안 반려동물의 체내 칼슘 및 인 농도가 안전한 범위 내에 있는지 확인하기 위해 지속적인 혈액 검사가 필요합니다.
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