아세트산 칼슘

경구용 인 결합제

아세트산 칼슘은 주로 만성 신장 질환(CKD)에 이차적으로 발생하는 고인산혈증 관리에 사용되는 경구용 인 결합제입니다. 탄산칼슘에 비해 인 결합 효율이 높아(원소 칼슘 1g당 약 2배의 인 결합) 의인성 고칼슘혈증의 위험이 낮습니다. 또한 구연산칼슘과 달리 위장관에서 알루미늄 흡수를 촉진하지 않습니다.

작용 기전: When administered with meals, calcium acetate dissociates in the gastrointestinal tract. The calcium ions then bind to dietary phosphorus in the stomach and proximal small intestine to form **calcium phosphate**, an insoluble complex. Dietary Phosphorus + Calcium Acetate → **Insoluble Calcium Phosphate** → Excreted in feces. This mechanism effectively reduces the gastrointestinal absorption of phosphorus, thereby lowering serum phosphorus levels. It is soluble over a wide range of pH, making it highly available for binding.

동물 종별 용량

Dogs

Hyperphosphatemia associated with chronic renal failure · 60-90 mg/kg/day · PO · divided with meals · In conjunction with a low-phosphorus diet. Give with food or mixed with food, or just prior to each meal. Individualize dose to achieve desired serum phosphorus concentrations. Decrease dose if serum calcium exceeds normal limits.
Hyperphosphatemia in CKD · 60-90 mg/kg/day divided · PO · divided with meals · Long-term · Dose must be titrated based on serum phosphorus levels. Must be given with food.

Cats

Hyperphosphatemia associated with chronic renal failure · 60-90 mg/kg/day · PO · divided with meals · In conjunction with a low-phosphorus diet. Give with food or mixed with food, or just prior to each meal. Individualize dose to achieve desired serum phosphorus concentrations. Decrease dose if serum calcium exceeds normal limits.
Hyperphosphatemia in CKD · 60-90 mg/kg/day divided · PO · divided with meals · Long-term · Dose must be titrated based on serum phosphorus levels. Must be given with food.

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

Pre-existing hypercalcemia

이상반응

Hypercalcemia
Gastrointestinal intolerance (nausea)

약물 상호작용

Calcitriol · May lead to hypercalcemia; if used concomitantly, intensified monitoring for hypercalcemia is mandatory.
Digoxin · Not recommended; hypercalcemia induced by calcium acetate may cause serious arrhythmias in patients on digoxin.
Fluoroquinolones · Oral calcium can reduce the absorption of fluoroquinolones. Separate dosages by at least two hours. · major
Tetracyclines · Oral calcium can reduce the absorption of tetracyclines. Separate dosages by at least two hours. · major
Levothyroxine · Decreased absorption of levothyroxine · moderate

모니터링

Serum phosphorus (after a 12-hour fast)
Serum ionized calcium
Monitor initially at 10-14 day intervals; once 'stable', at 4-6 week intervals

과용량

Acute overdoses could potentially cause **hypercalcemia**. - **Management:** Patients should be monitored and treated symptomatically. - If the dosage was massive and recent, consider using standard protocols to empty the gut (e.g., emesis induction or gastric lavage, followed by activated charcoal, though charcoal does not bind minerals well).

VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.