캡토프릴

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Hypersensitivity to ACE inhibitors

이상반응

• Hypotension
• Renal failure
• Hyperkalemia
• Vomiting
• Diarrhea
• Skin rashes (reported in humans, not dogs)
• Neutropenia/agranulocytosis (rare, reported in humans)

약물 상호작용

• Antacids · Reduced oral absorption of captopril; separate dosing by at least two hours.
• Cimetidine · Concomitant use has caused neurologic dysfunction in human patients.
• Digoxin · Digoxin levels may increase 15-30%; monitor serum digoxin levels.
• Diuretics · Concomitant use may cause hypotension; titrate dosages carefully.
• NSAIDs · May reduce the clinical efficacy of captopril when used as an antihypertensive agent.
• Potassium or Potassium-Sparing Diuretics (e.g., spironolactone) · Increased risk of developing hyperkalemia.
• Probenecid · Can decrease renal excretion of captopril, possibly enhancing clinical and toxic effects.
• Vasodilators (e.g., prazosin, hydralazine, nitrates) · Concomitant use may cause additive hypotension; titrate dosages carefully.

모니터링

• Clinical signs of CHF (respiratory rate/effort, exercise tolerance)
• Blood pressure (especially if treating hypertension or if signs of hypotension arise)
• Serum electrolytes (monitor for hyperkalemia)
• Renal panel (Creatinine, BUN)
• Urine protein
• CBC with differential (periodic)

과용량

The primary concern in an overdose situation is **hypotension**. * **Treatment:** Supportive treatment with volume expansion using normal saline is recommended to correct blood pressure. * **Toxicity thresholds:** Dogs given 1.5 g/kg orally developed emesis and decreased blood pressure. Dogs receiving doses greater than 6.6 mg/kg q8h may develop renal failure.