카프로펜

비스테로이드성 항염증제 (NSAID)

**카프로펜(Carprofen)**은 수의학에서 널리 사용되는 프로피온산 계열의 비스테로이드성 항염증제(NSAID)입니다. * **주요 용도:** 반려견의 골관절염과 관련된 통증 및 염증 관리, 연부 조직 및 정형외과 수술 후 통증 조절. * **임상 요점:** 효과가 매우 뛰어나지만 위장관, 신장 또는 간 부작용을 피하기 위해 신중한 환자 선택이 필요합니다. > **참고:** 카프로펜은 일반적으로 COX-2 선택적 NSAID로 간주되며, 이는 COX-1의 보호적 항상성 기능을 대부분 유지하면서 염증 경로를 표적으로 함을 의미합니다.

작용 기전: Carprofen produces its analgesic and anti-inflammatory effects via the inhibition of cyclooxygenase (COX) enzymes. **Arachidonic Acid** → **Cyclooxygenase (COX)** → **Prostaglandins & Thromboxanes** * **COX-1 Sparing:** It preferentially inhibits **COX-2** (induced during inflammation) over **COX-1** (constitutively expressed for GI and renal protection). * **Additional Mechanisms:** May also inhibit the release of several prostaglandins and modulate cellular and humoral immune responses.

동물 종별 용량

Cats

Post-operative pain · 4 mg/kg · SC/IV · Single dose · One time only · Use with extreme caution in cats due to limited glucuronidation capacity; single dose only. Not approved for multi-day use in cats in many countries.

Ferrets

Analgesia · 1-2 mg/kg · PO/SC · q12-24h · As needed

Cattle

Adjunct therapy for acute mastitis or respiratory disease · 1.4 mg/kg · SC/IV · Single dose · One time · Approved in some regions outside the US.

Horses

Pain and Inflammation · 0.7 mg/kg · IV · q24h · As needed · Used primarily outside the US.

Birds

Analgesia · 1-2 mg/kg · PO/IM/SC · q12-24h · As needed · Dosing varies significantly by species.

SmallMammals

Analgesia · 2-5 mg/kg · PO/SC · q12-24h · As needed · Commonly used in rabbits, guinea pigs, and rodents.

Dogs

Osteoarthritis and Pain Management · 4.4 mg/kg · PO/SC/IV · q24h or divided q12h · As needed · Can be given as a single daily dose or divided into 2.2 mg/kg twice daily.

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

POSCIV

금기

Bleeding disorders (e.g., Von Willebrand disease)
Active gastrointestinal ulceration
Hypersensitivity to carprofen or other NSAIDs
Concurrent use with other NSAIDs or corticosteroids

이상반응

Vomiting
Diarrhea
Anorexia
Lethargy
Gastrointestinal ulceration or bleeding
Hepatopathy (rare, idiosyncratic)
Renal toxicity

약물 상호작용

Corticosteroids · Significantly increased risk of gastrointestinal ulceration and perforation. · major
Other NSAIDs · Increased risk of GI, renal, and hepatic toxicity. · major
ACE Inhibitors · Potential for increased risk of renal toxicity and decreased hypotensive efficacy. · moderate
Phenobarbital · Potential for altered metabolism and increased risk of hepatotoxicity.
Furosemide · Decreased diuretic efficacy. · moderate

모니터링

Baseline blood work (CBC/Chemistry panel)
Liver enzymes (ALT, AST, ALP, Bilirubin)
Renal parameters (BUN, Creatinine, SDMA, USG)
Clinical signs of GI upset (vomiting, diarrhea, melena)

과용량

**Signs of Toxicity:** * **GI:** Vomiting, diarrhea, hematemesis, melena, GI ulceration/perforation. * **Renal:** Acute kidney injury (AKI), polyuria, polydipsia. * **Hepatic:** Elevated liver enzymes, icterus. * **Neurologic:** Seizures or coma in massive overdoses. **Treatment:** 1. **Decontamination:** Emesis induction (if recent and asymptomatic), followed by activated charcoal. 2. **GI Protectants:** Omeprazole, misoprostol, sucralfate. 3. **Fluid Therapy:** IV crystalloids to support renal perfusion and promote diuresis. 4. **Monitoring:** Serial monitoring of renal and hepatic values for at least 48-72 hours.

VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.