세포테탄

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Known hypersensitivity to cephamycins or cephalosporins
• Caution in patients with documented hypersensitivity to penicillins or other beta-lactams (cross-reactivity possible)
• Caution in patients with severe renal dysfunction (dose interval adjustment may be required)

이상반응

• Pain at IM injection site
• Thrombophlebitis (IV administration)
• Hypersensitivity reactions (rash, fever, anaphylaxis)
• Bleeding tendencies (hypoprothrombinemia due to NMTT side chain)
• Gastrointestinal flora alteration (diarrhea, superinfections)
• Rarely: nephrotoxicity, neurotoxicity, neutropenia, thrombocytopenia at high doses

약물 상호작용

• Alcohol · Potential for a disulfiram-like reaction (vomiting, etc.) due to the NMTT side chain.
• Aminoglycosides · Potential additive nephrotoxicity; do not mix together in the same syringe/fluid bag (administer separately). May have synergistic antibacterial activity.
• Nephrotoxic drugs (e.g., Amphotericin B) · Potential additive nephrotoxicity.

모니터링

• Clinical efficacy (resolution of infection)
• Renal function in patients with pre-existing renal disease
• Signs of bleeding or coagulopathy (due to NMTT side chain)

과용량

Massive or chronic overdoses are required to cause significant adverse effects. **Seizures** are possible with extreme beta-lactam overdoses, particularly in patients with renal impairment. Treatment is supportive and symptomatic.