세프티오퍼 결정 유리산

항생제 - 3세대 세팔로스포린

세프티오퍼 결정 유리산(CCFA)은 지속성 수의학 전용 **3세대 세팔로스포린**입니다. 면실유 기반으로 제조되어 1회 주사로 수일간 서방형 효과를 제공합니다. - **광범위 항균 활성:** 주요 그람 음성 및 양성 호흡기 병원체에 대해 높은 효능을 나타냅니다. - **대상 동물:** 소(소 호흡기 질환 및 지간부란), 돼지(돼지 호흡기 질환) 및 말(동물성 연쇄상구균에 의한 하기도 감염)에 사용하도록 FDA 승인을 받았습니다. - **임상적 장점:** 1회 투여(소/돼지) 또는 2회 투여(말)로 전체 치료 과정을 완료할 수 있어 순응도를 높이고 동물의 스트레스를 줄여줍니다.

작용 기전: Like other beta-lactam antibiotics, ceftiofur is a **time-dependent, bactericidal** agent. - It binds to **penicillin-binding proteins (PBPs)** → inhibits peptidoglycan cross-linking → disrupts bacterial cell wall synthesis → activates autolysins → cell lysis and death. - After administration, the parent compound is rapidly cleaved into furoic acid and **desfuroylceftiofur** (the primary active metabolite). - Desfuroylceftiofur is equally potent to the parent drug and exhibits a spectrum of activity similar to cefotaxime. High protein binding creates a 'reservoir effect' to maintain active drug levels at the site of infection.

동물 종별 용량

Cattle

BRD treatment (Beef and lactating cattle) · 3 mg per lb (6.6 mg ceftiofur equivalents per kg) body weight (1.5 mL sterile suspension per 100 lb body weight) · SC · Single dose · Single dose · Administer as a single SC injection in the posterior aspect of the ear where it attaches to the head at the base of the ear (BOE).
BRD treatment (Beef and non-lactating dairy cattle) · 6.6 mg ceftiofur equivalents/kg body weight (1.5 mL sterile suspension per 100 lb body weight) · SC · Single dose · Single dose · Administer as a single SC injection in the middle third of the posterior aspect of the ear.
BRD control (Beef and non-lactating dairy cattle) · 6.6 mg ceftiofur equivalents (CE)/kg body weight (1.5 mL sterile suspension per 100 lb body weight) · SC · Single dose · Single dose · Administer as a SC injection either in the middle third of the posterior aspect of the ear or at the base of the ear.

Horses

Lower respiratory tract infections caused by susceptible strains of Streptococcus equi ssp. zooepidemicus · 6.6 mg/kg IM; repeat in 4 days · IM · repeat in 4 days · 2 doses total · A maximum of 20 mL per injection site may be administered. Shake well before using.

Swine

Swine respiratory disease (SRD) · 2.27 mg ceftiofur equivalents (CE) per lb (5 mg CE/kg) body weight · IM · Single dose · Single dose · Administer in the post-auricular region of the neck. No more than 2 mL should be injected in a single injection site. Pigs heavier than 88 lb (40 kg) will require more than one injection.

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

SCIM

금기

Patients with a history of hypersensitivity to cephalosporins
Use with caution in patients with documented hypersensitivity to other beta-lactams (penicillins, carbapenems)
Do not use in pre-ruminating calves to be processed for veal

이상반응

Hypersensitivity reactions (rashes, fever, eosinophilia, anaphylaxis)
Granulocytopenia and thrombocytopenia (rare)
Diarrhea, soft or loose stools (especially in horses)
Injection site reactions: swelling, thickening, aseptic cellular infiltrate, discoloration
Sudden death in cattle if injected into ear arteries

약물 상호작용

Aminoglycosides / Nephrotoxic drugs · Potential additive nephrotoxicity. Do not mix in the same syringe or IV line.
Probenecid · Competitively blocks the tubular secretion of most cephalosporins, thereby increasing serum levels and serum half-lives.

모니터링

Clinical efficacy (resolution of respiratory signs within 3-5 days)
Injection site reactions (swelling, inflammation)
Fecal consistency (monitor for diarrhea, especially in horses)
CBC (if used off-label in small animals)
Renal function in patients with pre-existing renal compromise

과용량

Cephalosporin overdoses are unlikely to cause significant systemic toxicity other than **gastrointestinal distress** and potential injection site reactions. > **Regulatory Warning:** Use of dosages in excess of labeled recommendations (e.g., >6.6 mg/kg in cattle or >5 mg/kg in swine) or administration by unapproved routes (e.g., SC in the neck or IM in cattle) will likely cause **violative tissue residues**. Contact FARAD for assistance in determining appropriate extended withdrawal times if an overdose occurs.

VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.