세프티오퍼 결정 유리산
Ceftiofur Crystalline Free Acid
다른 이름: Excede · CCFA · CM-31916 · ceftiofuri
VetSheet 수의사 팀 검수업데이트 2026년 4월 5일근거 기반 수의학 참고자료
용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.
동물 종별 용량
🌎 NA — North America🌍 EU — Europe
말
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Lower respiratory tract infections caused by susceptible strains of Streptococcus equi ssp. zooepidemicus | 6.6 mg/kg IM; repeat in 4 days | IM | repeat in 4 days | 2 doses total | 🌎 NA |
- Lower respiratory tract infections caused by susceptible strains of Streptococcus equi ssp. zooepidemicus: A maximum of 20 mL per injection site may be administered. Shake well before using.
소
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| BRD treatment (Beef and lactating cattle) | 3 mg per lb (6.6 mg ceftiofur equivalents per kg) body weight (1.5 mL sterile suspension per 100 lb body weight) | SC | Single dose | Single dose | 🌎 NA |
| BRD treatment (Beef and non-lactating dairy cattle) | 6.6 mg ceftiofur equivalents/kg body weight (1.5 mL sterile suspension per 100 lb body weight) | SC | Single dose | Single dose | 🌎 NA |
| BRD control (Beef and non-lactating dairy cattle) | 6.6 mg ceftiofur equivalents (CE)/kg body weight (1.5 mL sterile suspension per 100 lb body weight) | SC | Single dose | Single dose | 🌎 NA |
- BRD treatment (Beef and lactating cattle): Administer as a single SC injection in the posterior aspect of the ear where it attaches to the head at the base of the ear (BOE).
- BRD treatment (Beef and non-lactating dairy cattle): Administer as a single SC injection in the middle third of the posterior aspect of the ear.
- BRD control (Beef and non-lactating dairy cattle): Administer as a SC injection either in the middle third of the posterior aspect of the ear or at the base of the ear.
돼지
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Swine respiratory disease (SRD) | 2.27 mg ceftiofur equivalents (CE) per lb (5 mg CE/kg) body weight | IM | Single dose | Single dose | 🌎 NA |
- Swine respiratory disease (SRD): Administer in the post-auricular region of the neck. No more than 2 mL should be injected in a single injection site. Pigs heavier than 88 lb (40 kg) will require more than one injection.
용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.
개요
세프티오퍼 결정 유리산(CCFA)은 지속성 수의학 전용 3세대 세팔로스포린입니다. 면실유 기반으로 제조되어 1회 주사로 수일간 서방형 효과를 제공합니다.
- 광범위 항균 활성: 주요 그람 음성 및 양성 호흡기 병원체에 대해 높은 효능을 나타냅니다.
- 대상 동물: 소(소 호흡기 질환 및 지간부란), 돼지(돼지 호흡기 질환) 및 말(동물성 연쇄상구균에 의한 하기도 감염)에 사용하도록 FDA 승인을 받았습니다.
- 임상적 장점: 1회 투여(소/돼지) 또는 2회 투여(말)로 전체 치료 과정을 완료할 수 있어 순응도를 높이고 동물의 스트레스를 줄여줍니다.
작용 기전
Like other beta-lactam antibiotics, ceftiofur is a time-dependent, bactericidal agent.
- It binds to penicillin-binding proteins (PBPs) → inhibits peptidoglycan cross-linking → disrupts bacterial cell wall synthesis → activates autolysins → cell lysis and death.
- After administration, the parent compound is rapidly cleaved into furoic acid and desfuroylceftiofur (the primary active metabolite).
- Desfuroylceftiofur is equally potent to the parent drug and exhibits a spectrum of activity similar to cefotaxime. High protein binding creates a 'reservoir effect' to maintain active drug levels at the site of infection.
안전성·주의사항
금기사항
- Patients with a history of hypersensitivity to cephalosporins
- Use with caution in patients with documented hypersensitivity to other beta-lactams (penicillins, carbapenems)
- Do not use in pre-ruminating calves to be processed for veal
부작용
- Hypersensitivity reactions (rashes, fever, eosinophilia, anaphylaxis)
- Granulocytopenia and thrombocytopenia (rare)
- Diarrhea, soft or loose stools (especially in horses)
- Injection site reactions: swelling, thickening, aseptic cellular infiltrate, discoloration
- Sudden death in cattle if injected into ear arteries
주의
CRITICAL WARNING: Administration of ceftiofur free acid into the ear arteries is likely to result in sudden death in cattle.
- Human Safety: Avoid direct contact with skin, eyes, mouth, and clothing. Wear latex gloves to prevent sensitization. Persons with known penicillin/cephalosporin hypersensitivity should avoid exposure.
- Residue Warnings: Strictly observe slaughter withdrawal times (13 days for cattle, 14 days for swine). Extra-label use or exceeding maximum injection volumes per site may result in violative residues.
- Equine Precautions: If acute diarrhea is observed, do not administer additional doses and initiate appropriate therapy. Not evaluated in horses <4 months of age, or breeding, pregnant, or lactating horses. Due to prolonged clearance (~17 days to eliminate 97%), adverse reactions may require prolonged care.
약물 상호작용
Potential additive nephrotoxicity. Do not mix in the same syringe or IV line.
Competitively blocks the tubular secretion of most cephalosporins, thereby increasing serum levels and serum half-lives.
모니터링
- Clinical efficacy (resolution of respiratory signs within 3-5 days)
- Injection site reactions (swelling, inflammation)
- Fecal consistency (monitor for diarrhea, especially in horses)
- CBC (if used off-label in small animals)
- Renal function in patients with pre-existing renal compromise
약동학
반감기
흡수
Cattle (SC): Provides therapeutic concentrations above MIC90 for generally not less than 150 hours. Swine (IM): Therapeutic levels reached within 1 hour and maintained for an average of 8 days. Horses (IM): Slowly absorbed; peak serum level at ~22 hours (first dose) and ~16 hours (second dose), maintaining therapeutic levels for 10 days.
분포
High protein binding creates a 'reservoir effect' to maintain active levels at the site of infection.
대사
Rapidly cleaved into furoic acid and desfuroylceftiofur (the primary active metabolite).
배설
Horses: Approximately 17 days are needed to eliminate 97% of the dose from the body.
과다투여
Cephalosporin overdoses are unlikely to cause significant systemic toxicity other than gastrointestinal distress and potential injection site reactions.
Regulatory Warning: Use of dosages in excess of labeled recommendations (e.g., >6.6 mg/kg in cattle or >5 mg/kg in swine) or administration by unapproved routes (e.g., SC in the neck or IM in cattle) will likely cause violative tissue residues. Contact FARAD for assistance in determining appropriate extended withdrawal times if an overdose occurs.
제품
제형
- Sterile suspension (100 mg/mL ceftiofur equivalents)
- Sterile suspension (200 mg/mL ceftiofur equivalents)
동물용의약품
- Ceftiofur Crystalline Free Acid equivalent to 200 mg/mL ceftiofur in 100 mL vials (Excede for Cattle/Horses)
- Ceftiofur Crystalline Free Acid equivalent to 100 mg/mL ceftiofur in 100 mL vials (Excede for Swine)
규제 현황
규제 데이터 없음: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
보관·안정성
Store at controlled room temperature 20-25°C (68-77°F). Shake well before using. Contents should be used within 12 weeks after the first dose is removed.
보호자 정보
말 보호자 안내:
- 설사 주의: 이 약물을 투여받은 후 말에게 묽은 변이나 설사가 발생하면 즉시 수의사에게 연락하고 두 번째 투여를 중단하십시오.
- 주사 부위 부종: 주사 부위에 가벼운 부종이나 통증이 발생할 수 있습니다. 해당 부위를 관찰하고 심각하거나 진물이 나는 병변이 있으면 보고하십시오.
- 지속적인 작용: 이 약물은 체내에 장기간(2주 이상) 머물도록 설계되었습니다. 따라서 부작용이 발생할 경우 장기적인 수의학적 관리가 필요할 수 있습니다.
축산 농가 안내:
- 휴약 기간: 식육 내 불법 약물 잔류를 방지하기 위해 도축 휴약 기간(소 13일, 돼지 14일)을 엄격히 준수하십시오.
- 우유 폐기: 착유우의 경우 라벨 지시대로 귀 밑부분에 정확히 투여했을 때만 우유 폐기 기간이 0일입니다.
- 주사 기술: 안전성을 확보하고 지육 손실을 방지하기 위해 올바른 주사 기술과 부위 선정이 매우 중요합니다.
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