세프티오퍼 염산염

동물 종별 용량

투여 경로

금기

• Patients with a documented history of hypersensitivity to cephalosporins
• Use with caution in patients hypersensitive to other beta-lactam antibiotics (e.g., penicillins, carbapenems) due to potential cross-reactivity

이상반응

• Pain on IM injection (especially in small animals)
• Hypersensitivity reactions (rashes, fever, eosinophilia, lymphadenopathy, anaphylaxis)
• Gastrointestinal distress / diarrhea
• Granulocytopenia (rare)
• Thrombocytopenia (rare)
• Injection site discoloration

약물 상호작용

• Aminoglycosides / Nephrotoxic Drugs (e.g., amphotericin B) · Potential for additive nephrotoxicity. In vitro studies show synergistic antibacterial activity, but they must NOT be mixed together in the same syringe or fluid line.
• Probenecid · Competitively blocks the tubular secretion of most cephalosporins, thereby increasing serum levels and prolonging serum half-lives.
• Aminoglycosides · Synergistic antibacterial effect, but should not be mixed in the same syringe due to chemical incompatibility. · moderate
• Amphotericin B · Increased risk of nephrotoxicity. · major
• Loop diuretics (e.g., furosemide) · Increased risk of nephrotoxicity. · major

모니터링

• Clinical efficacy and resolution of infection
• Weekly CBC monitoring (if used off-label in small animals)
• Renal function parameters in patients with pre-existing renal impairment
• Injection site reactions

과용량

Cephalosporin overdoses are generally well-tolerated and unlikely to cause significant problems other than gastrointestinal distress. However, extreme overdoses could theoretically induce hypersensitivity or hematologic abnormalities. > **Important:** Use of dosages in excess of those labeled or via unapproved routes may cause violative tissue or milk residues. Contact FARAD for assistance in determining appropriate withdrawal times if an overdose occurs in food-producing animals.