์ธํฐ๋ฆฌ์ง
**์ธํฐ๋ฆฌ์ง(Cetirizine)**์ **2์ธ๋ ํญํ์คํ๋ฏผ์ **๋ก ์ธ์์์ ๋๋ฆฌ ์ฌ์ฉ๋๋ฉฐ, ๊ฐ์ ๊ณ ์์ด์ ์๋ ๋ฅด๊ธฐ ๋ฐ ํ์คํ๋ฏผ ๋งค๊ฐ์ฑ ์์์ฆ(๊ฐ๋ ค์์ฆ)์ ๋ณด์กฐ ์น๋ฃ์ ๋ก ์์ํ์์๋ ์ฌ์ฉ์ด ์ฆ๊ฐํ๊ณ ์์ต๋๋ค. * **๋น์ง์ ์ฑ** : 1์ธ๋ ํญํ์คํ๋ฏผ์ (์: ๋ํํ๋๋ผ๋ฏผ)์ ๋ฌ๋ฆฌ ์ธํฐ๋ฆฌ์ง์ ํ์ค ์ฉ๋์์ ํ์ก๋์ฅ๋ฒฝ(BBB)์ ์ ํต๊ณผํ์ง ๋ชปํ์ฌ ์ง์ ์์ฉ(์กธ์)์ด ํจ์ฌ ์ ์ต๋๋ค. * **ํ์ฑ ๋์ฌ์ฒด** : ํผํ๋ผ์ง๊ณ ์ ๋์ฒด์ด๋ฉฐ, ํ์ด๋๋ก์์ง(Hydroxyzine)์ ์ฃผ์ ์ธ์ฒด ํ์ฑ ๋์ฌ์ฒด์ ๋๋ค. * **์์์ ์ ์ฉ์ฑ** : ์ฃผ๋ก ๊ฐ์ ๊ณ ์์ด์ ์ํ ํผ ํผ๋ถ์ผ, ๊ณ ์์ด์ ๋ง์ฑ ๋น๋ถ๋น๋์ผ ๋ณด์กฐ ์น๋ฃ, ๊ทธ๋ฆฌ๊ณ ๊ฐํน ๋ง์ ์๋ ๋ฅด๊ธฐ ์งํ์ ์ฌ์ฉ๋ฉ๋๋ค. ๋ฐ๋ ค๋๋ฌผ์ ์ฌํ ์๋ ๋ฅด๊ธฐ ๋ฐ์ ์ ๋จ๋ ์๋ฒ์ผ๋ก๋ ์ฌ๋์ ๋นํด ํจ๊ณผ๊ฐ ๋จ์ด์ง ์ ์์ผ๋, ์คํ ๋ก์ด๋ ์ฌ์ฉ์ ์ค์ด๊ธฐ ์ํ ๋ค์ค ๋ชจ๋ ์ ๊ทผ๋ฒ์ ์ผ๋ถ๋ก์ ๊ฐ์น๊ฐ ์์ต๋๋ค.
์์ฉ ๊ธฐ์ : Cetirizine acts as a highly selective, competitive antagonist at peripheral **H1 receptors**. * **Allergic cascade**: Allergen exposure โ Mast cell/basophil degranulation โ **Histamine** release โ Binds to **H1 receptors** on sensory nerve endings and blood vessels โ Pruritus, vasodilation, and edema. * Cetirizine competitively blocks this binding, preventing histamine-mediated effects. * It also appears to decrease histamine release from basophils in some species, though experimental studies in cats showed it does not reduce eosinophilic airway inflammation. * It lacks significant anticholinergic or anti-serotonergic activity, and tolerance to its antihistaminic effects is not thought to occur.
๋๋ฌผ ์ข ๋ณ ์ฉ๋
- For adjunctive treatment of non-responsive chronic rhinosinusitis ยท 5 mg (total dose) PO q12h ยท PO ยท q12h
- General antihistamine use ยท 5 mg (total dose) per cat PO once daily ยท PO ยท q24h ยท No controlled studies evaluating effectiveness against other antihistamines.
- For adjunctive treatment of pruritus ยท 2.5-5 mg (total dose) per cat once daily ยท PO ยท q24h
- Antihistamine ยท 0.2-0.4 mg/kg PO q12h ยท PO ยท q12h ยท Based on pharmacokinetic and pharmacodynamic data, may be a useful antihistamine in horses.
- For atopic dermatitis ยท 1 mg/kg PO once daily with or without food ยท PO ยท q24h ยท Satisfactory control of pruritus in 18% of dogs evaluated in the study.
- For atopic dermatitis ยท 5-10 mg (total dose) PO once daily ยท PO ยท q24h
- For allergic dermatitis ยท 1 mg/kg PO q12h ยท PO ยท q12h
- For adjunctive treatment of pruritus ยท 0.5-1 mg/kg or 5-10 mg total dose once to twice daily ยท PO ยท q12-24h
์ฉ๋์ ๋ฉดํ ์์ ์ ๋ฌธ๊ฐ๋ฅผ ์ํ ์์ ์ฐธ๊ณ ์๋ฃ์ ๋๋ค. ํญ์ ์ต์ ๋ผ๋ฒจ๊ณผ ๊ฐ๋ณ ํ์์ ๋ํด ํ์ธํ์ญ์์ค.
ํฌ์ฌ ๊ฒฝ๋ก
๊ธ๊ธฐ
- Hypersensitivity to cetirizine or hydroxyzine
- Combination products containing pseudoephedrine (e.g., Zyrtec-D) are strictly contraindicated in dogs and cats
์ด์๋ฐ์
- Vomiting
- Hypersalivation (drooling)
- Somnolence (drowsiness/sedation, especially in small dogs at higher dosages)
- Dry mouth (reported in humans)
์ฝ๋ฌผ ์ํธ์์ฉ
- CNS Depressants ยท Additive CNS depression if used concurrently with cetirizine ยท minor
๋ชจ๋ํฐ๋ง
- Clinical efficacy (reduction in pruritus or allergic signs)
- Adverse effects (vomiting, hypersalivation, somnolence)
๊ณผ์ฉ๋
Cetirizine generally has a wide margin of safety. * **Massive Overdose**: May cross the blood-brain barrier in overdose situations, leading to neurologic signs (hyperactivity or severe sedation). * **Cardiovascular Safety**: Unlike earlier non-sedating antihistamines (terfenadine and astemizole), cetirizine does not appreciably prolong the QT interval on ECG at high serum levels. * > **TOXICITY ALERT**: Overdoses of cetirizine products that also contain pseudoephedrine (e.g., Zyrtec-D 12 Hour) are highly dangerous and potentially fatal. Immediate veterinary intervention and consultation with an animal poison control center are required.
VetSheet ์ฝ๋ฌผ ๋ ํผ๋ฐ์ค๋ ๋ฉดํ ์์ ์ ๋ฌธ๊ฐ๋ฅผ ์ํ ์์ ์์ฌ๊ฒฐ์ ๋ณด์กฐ ๋๊ตฌ์ด๋ฉฐ, ์ ๋ฌธ์ ํ๋จ์ด๋ ์ ์กฐ์ฌ์ ์ต์ ๋ผ๋ฒจ์ ๋์ ํ์ง ์์ต๋๋ค.