클로로티아지드

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Hypersensitivity to thiazides or sulfonamides
• Anuria
• Pregnancy in otherwise healthy females with only mild edema (relative contraindication)

이상반응

• Hypokalemia
• Hypochloremic alkalosis
• Dilutional hyponatremia
• Hypomagnesemia
• Hypercalcemia
• Hypophosphatemia
• Hyperuricemia
• Gastrointestinal distress (vomiting, diarrhea)
• Pancreatitis
• Hypersensitivity / dermatologic reactions
• Polyuria
• Hematologic toxicity
• Hyperglycemia
• Hyperlipidemias
• Orthostatic hypotension

약물 상호작용

• Amphotericin B · Increased risk for severe hypokalemia
• Corticosteroids / Corticotropin · Increased risk for severe hypokalemia
• Diazoxide · Increased risk for hyperglycemia, hyperuricemia, and hypotension
• Digitalis / Digoxin · Thiazide-induced hypokalemia, hypomagnesemia, and/or hypercalcemia may increase the likelihood of digitalis toxicity
• Insulin · Thiazides may increase insulin requirements
• Lithium · Thiazides can increase serum lithium concentrations
• Methenamine · Thiazides can alkalinize urine and reduce methenamine effectiveness
• NSAIDs · May increase risk for renal toxicity; NSAIDs may reduce diuretic actions of thiazides
• Neuromuscular blocking agents · Response or duration of nondepolarizing agents (e.g., tubocurarine) may be increased
• Probenecid · Blocks thiazide-induced uric acid retention
• Quinidine · Half-life may be prolonged by thiazides due to urine alkalinization
• Vitamin D or Calcium Salts · Hypercalcemia may be exacerbated

모니터링

• Serum electrolytes (especially potassium)
• BUN and Creatinine
• Blood glucose
• Hydration status
• Blood pressure (if indicated)
• Hemograms (if indicated)

과용량

Acute overdosage may cause **electrolyte and water balance problems**, CNS effects (ranging from lethargy to coma and seizures), and GI effects (hypermotility, GI distress). Transient increases in BUN have also been reported. **Treatment:** * Empty the gut after recent oral ingestion using standard protocols. * **Avoid concomitant cathartics** as they may exacerbate fluid and electrolyte imbalances. * Monitor and treat electrolyte and water balance abnormalities supportively. * Monitor respiratory, CNS, and cardiovascular status; provide symptomatic and supportive care as required.