ํด๋ก๋ฅดํ ํธ๋ผ์ฌ์ดํด๋ฆฐ
ํด๋ก๋ฅดํ ํธ๋ผ์ฌ์ดํด๋ฆฐ์ ๊ด๋ฒ์ 1์ธ๋ **ํ ํธ๋ผ์ฌ์ดํด๋ฆฐ๊ณ ํญ์์ **์ ๋๋ค. ์ฅ์ํ ํธ๋ผ์ฌ์ดํด๋ฆฐ ๋ฐ ํ ํธ๋ผ์ฌ์ดํด๋ฆฐ๊ณผ ๊ฑฐ์ ๋์ผํ ํญ๊ท ์คํํธ๋ผ์ ๊ณต์ ํ์ง๋ง, ์์ํ์์๋ ์ฃผ๋ก ์ฐ์ ๋๋ฌผ(์, ๋ผ์ง, ๊ฐ๊ธ๋ฅ)์ ์ฌ๋ฃ๋ ์์ ์ฒจ๊ฐ์ ๋ก ์ฌ์ฉ๋ฉ๋๋ค. ์ฃผ์ ์์์ ํน์ง: * **๊ด๋ฒ์ ํญ๊ท ๋ ฅ:** ๋ง์ ๋ง์ด์ฝํ๋ผ์ค๋ง, ์คํผ๋กํคํ(๋ผ์๋ณ ์์ธ๊ท ํฌํจ), ํด๋ผ๋ฏธ๋์, ๋ฆฌ์ผ์ฐจ์ ํจ๊ณผ์ ์ ๋๋ค. * **๋ด์ฑ ์ฆ๊ฐ:** ๋ง์ ๊ทธ๋ ์์ฑ ๋ฐ ์์ฑ ์ธ๊ท (์: ๋์ฅ๊ท , ํด๋ ๋ธ์์๋ผ, ๋ น๋๊ท )์ด ๋ด์ฑ์ ๋ณด์ ๋๋ค. * **ํน์๋๋ฌผ ์ฌ์ฉ:** ์กฐ๋ฅ(ํนํ ํด๋ผ๋ฏธ๋์์ฆ) ๋ฐ ์ผ๋ถ ์ํ ํฌ์ ๋ฅ์ ์์ฃผ ์ฌ์ฉ๋์ง๋ง, ๊ธฐ๋ํผ๊ทธ์์๋ ์น๋ช ์ ์ธ ์ฅ๋ ํ์ฆ์ ์ ๋ฐํ๋ฏ๋ก **์ ๋ ๊ธ๊ธฐ**์ ๋๋ค.
์์ฉ ๊ธฐ์ : Chlortetracycline is a **bacteriostatic** antibiotic that inhibits bacterial protein synthesis. * **Primary Mechanism:** Reversibly binds to the **30S ribosomal subunit** of susceptible organisms → blocks the binding of aminoacyl transfer-RNA to the mRNA-ribosome complex → halts peptide chain elongation. * **Secondary Mechanism:** May also reversibly bind to **50S ribosomes** and alter cytoplasmic membrane permeability. * **Mammalian effects:** At very high concentrations, it can inhibit protein synthesis in mammalian cells, leading to antianabolic effects.
๋๋ฌผ ์ข ๋ณ ์ฉ๋
- Susceptible infections ยท 25 mg/kg PO q6-8h ยท PO ยท q6-8h
- Bacterial conjunctivitis, keratitis, blepharitis, and spontaneous chronic corneal epithelial defects (SCCEDs) ยท 0.5-2 cm of ointment to affected eye ยท topical ยท q6h ยท 5 days ยท Used for immunomodulatory mechanism in SCCEDs.
- Chlamydiosis (Small birds) ยท 0.05% concentration in food ยท PO ยท Continuous
- Chlamydiosis (Larger psittacines) ยท 1% CTC concentration in food ยท PO ยท Continuous
- Susceptible infections (Ratites) ยท 15-20 mg/kg PO three times daily ยท PO ยท TID
- Susceptible infections (Pigeons) ยท 50 mg/kg PO q6-8h; or 1000-1500 mg/gallon drinking water ยท PO ยท q6-8h or continuous ยท In warm weather mix fresh every 12 hours. Calcium inhibits absorption; withhold grit and layer pellets during treatment.
- Susceptible infections ยท 25 mg/kg PO q6-8h ยท PO ยท q6-8h
- To prevent recurrence of mycoplasma or chlamydial conjunctivitis in large catteries ยท 50 mg per day per cat ยท PO ยท q24h ยท 1 month ยท Administer soluble chlortetracycline powder in food.
- Feline chlamydial conjunctivitis, mycoplasmal conjunctivitis, bacterial keratitis/blepharitis ยท 0.5-2 cm of ointment to affected eye ยท topical ยท q6h ยท 5 days ยท Oral doxycycline is the treatment of choice for feline chlamydial conjunctivitis.
ํฌ์ฌ ๊ฒฝ๋ก
๊ธ๊ธฐ
- Known hypersensitivity to chlortetracycline or other tetracyclines
- Guinea pigs (causes fatal clostridial enterotoxemia)
์ด์๋ฐ์
- Gastrointestinal distress (nausea, vomiting, anorexia, diarrhea)
- Discoloration of developing teeth and bones (yellow, brown, or gray)
- Delayed bone growth and healing (at high doses)
- Hepatotoxicity
- Increased BUN (antianabolic effect)
- Ruminal microflora depression and stasis (in ruminants)
- Intravascular hemolysis and hemoglobinuria (with rapid IV injection of propylene glycol-based products)
- Colic, fever, and hair loss (in cats)
- Severe diarrhea (in stressed horses)
- Superinfections (bacterial or fungal overgrowth)
- Photosensitivity
์ฝ๋ฌผ ์ํธ์์ฉ
- Beta-lactam Antibiotics ยท Bacteriostatic action of tetracyclines may interfere with the bactericidal activity of penicillins and cephalosporins.
- Aminoglycosides ยท May interfere with bactericidal activity.
- Digoxin ยท May increase the bioavailability of digoxin in a small percentage of patients, potentially leading to toxicity.
- Divalent or Trivalent Cations (Antacids, Calcium, Iron, Magnesium, Zinc, Bismuth) ยท Chelation occurs, significantly decreasing the oral absorption of the tetracycline. Separate administration by at least 1-2 hours.
- Warfarin ยท May depress plasma prothrombin activity; anticoagulant dosage may need adjustment.
๋ชจ๋ํฐ๋ง
- Clinical efficacy (resolution of infection)
- Gastrointestinal signs (vomiting, diarrhea, anorexia)
- Renal function (BUN, creatinine) and hepatic function, especially with prolonged use or in compromised patients
- Fluid and electrolyte status if severe GI distress occurs
๊ณผ์ฉ๋
Tetracyclines are generally well tolerated after acute overdoses. * **Oral Overdose:** Most likely associated with gastrointestinal disturbances (vomiting, anorexia, diarrhea). If severe emesis or diarrhea develops, monitor and replace fluids and electrolytes. * **Chronic Overdose:** May lead to drug accumulation and nephrotoxicity. * **Ruminants:** High oral doses can cause ruminal microflora depression and ruminoreticular stasis. * **Intravenous Overdose:** Rapid IV injection of undiluted propylene glycol-based products can cause intravascular hemolysis and hemoglobinuria. Rapid IV injection can also induce transient collapse and cardiac arrhythmias due to chelation with intravascular calcium ions.
VetSheet ์ฝ๋ฌผ ๋ ํผ๋ฐ์ค๋ ๋ฉดํ ์์ ์ ๋ฌธ๊ฐ๋ฅผ ์ํ ์์ ์์ฌ๊ฒฐ์ ๋ณด์กฐ ๋๊ตฌ์ด๋ฉฐ, ์ ๋ฌธ์ ํ๋จ์ด๋ ์ ์กฐ์ฌ์ ์ต์ ๋ผ๋ฒจ์ ๋์ ํ์ง ์์ต๋๋ค.