융모막 생식샘 자극 호르몬 (HCG)

생식 호르몬 / 생식샘 자극 호르몬

HCG는 임산부의 소변에서 추출한 폴리펩타이드 호르몬으로, 주로 황체 형성 호르몬(LH)의 작용을 모방하며 일부 난포 자극 호르몬(FSH) 활성을 가집니다. 수의학에서는 소의 낭종성 난소, 잠복고환증 치료 및 생식샘 기능을 평가하기 위한 HCG 자극 검사 등 다양한 동물의 번식 장애에 널리 사용됩니다.

작용 기전: HCG is a glycoprotein that primarily mimics the action of **luteinizing hormone (LH)**, with minor **follicle-stimulating hormone (FSH)**-like activity. * **In Males:** Binds to LH receptors on testicular interstitial (**Leydig**) cells → stimulates differentiation and **androgen (testosterone)** production → promotes testicular descent and spermatogenesis. * **In Females:** Binds to LH receptors on the ovary → stimulates the **corpus luteum** to produce **progesterone** → triggers ovulation of mature follicles. In bitches, it also induces estrogen secretion.

동물 종별 용량

Cats

HCG Challenge test (Male cats or females with suspected sexual differentiation disorder) · 250 micrograms · IM · once · Take sample for resting testosterone level. Administer HCG and take a 4 hour post sample.
HCG Challenge test (Queens to diagnose functional ovarian tissue) · 50-100 Units · IM · once · Give during apparent estrous episode. Measure progesterone level in 5-7 days. >1 ng/mL indicates functional tissue.
Infertility, reduced libido, testis descent in male cats · 50-100 Units · IM/SC · repeated if necessary
Infertility in queens due to confirmed ovulation failure · 100-500 Units · IM · once
To induce ovulation in anestrus queens · 250 micrograms · IM · once daily for 2 days · 2 days · Give FSH-P 2 mg IM daily until estrus is observed. Give HCG on first and second day of estrus.
After artificial insemination · 50-75 Units · IM · immediately after insemination; repeat in 24 hours · 24 hours

Ferrets

Estrus management · 100 Units · IM · repeat in 1 week as necessary · Most effective 14 days after onset of estrus.

Cattle

Treatment of ovarian cysts · 10,000 Units deep IM or 2500-5000 Units IV. Alternatively, 500-2500 Units injected directly into the follicle. · IM/IV/Intrafollicular · once · May repeat in 14 days if animal's behavior or physical exam indicates a need for retreatment.

Horses

Cryptorchidism (Foals) · 1000 Units · IM/SC · twice weekly · 4-6 weeks · Note: Many clinicians believe that medical treatment is unwarranted and that surgery should be performed.
To induce ovulation in early estrus (dominant follicle >35 mm) · 2000-3000 Units · IV · once · Preferable to treat mare 6 hours before mating.
Treatment of persistent follicles during the early transition period · 1000-5000 Units · IM/IV · once · Results are variable.
To hasten ovulation and reduce variability of estrus after prostaglandin synchronization · 1500-3300 Units · IM/IV · once · Give 5-6 days after the second prostaglandin treatment or on the first or second day of estrus.

Birds

To reduce feather plucking (especially in female birds) · 500-1,000 Units/kg · IM · once · Dosage is empirical. If no response in 3 days, repeat. If reduces feather plucking, will need to repeat after 4-6 weeks. Repeated usage reduces time between treatments.

SmallMammals

Cystic ovaries (Guinea pigs) · 1000 Units/animal · IM · repeat in 7-10 days

Dogs

Cryptorchidism · 500 Units injected twice weekly · IM/SC · twice weekly · 4-6 weeks
HCG Challenge test (Male dogs or females with suspected sexual differentiation disorder) · 44 micrograms/kg · IM · once · Take sample for resting testosterone level. Administer HCG and take a 4 hour post sample.
HCG Challenge test (Female dogs to diagnose functional ovarian tissue) · 100-1000 Units · IM · once · Give during apparent estrous episode. Measure progesterone level in 5-7 days. >1 ng/mL indicates functional tissue.
To produce luteinization of a persistent follicular cyst · 500 Units · IM · repeat in 48 hours · If effective, will convert from proestrus to estrus in 1-2 days and sexual behavior should stop within 2 weeks.
Infertile bitches cycling normally with low progesterone due to lack of corpus luteum formation · 500 Units · SC · once · Give on days 10-11 of heat cycle or when vaginal smear indicates breeding readiness. Breed 2 days after administration.
Male infertility secondary to low testosterone, LH and FSH · 500 Units · SC · twice weekly · 4 weeks · Add PMSG 20 Units/kg SC 3 times weekly. Continue for 3 months. Once spermatogenesis ensues, may continue with HCG only.

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

IMIVSCIntrafollicular

금기

Androgen-dependent neoplasias (e.g., prostatic carcinoma)
Precocious puberty
Known hypersensitivity to HCG
Pregnancy (FDA Category X in humans, unless specifically indicated for reproductive management)

이상반응

Hypersensitivity reactions / Anaphylaxis
Pain at the injection site
Antibody production leading to diminished efficacy (with repeated use)
Abortion in mares if given prior to the 35th day of pregnancy
Gynecomastia, headache, depression, irritability, and edema (reported in humans)

모니터링

Testosterone levels (for HCG challenge test in males)
Progesterone levels (for HCG challenge test in females)
Resolution of clinical signs (e.g., cessation of estrus behavior, resolution of cystic ovaries)
Signs of hypersensitivity or anaphylaxis post-injection

과용량

No overdosage cases have been reported with HCG in veterinary medicine.

VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.