ํฌ๋ก๋ฎด ํผ์ฝ๋ฆฌ๋ค์ดํธ
ํฌ๋ก๋ฎด ํผ์ฝ๋ฆฌ๋ค์ดํธ๋ ํนํ ๊ณ ์์ด์ ๋น๋จ๋ณ ๋ฐ ๋น๋ง ๋ณด์กฐ ์น๋ฃ์ ๋ก ์ฌ์ฉ๋ ์ ์๋ ๋ฏธ๋ ๊ธ์ ์์ ๋ณด์ถฉ์ ์ ๋๋ค. ์์์ ํจ๋ฅ์ ๋ํด์๋ ๋ ผ๋์ด ์์ผ๋ฉฐ, ๋น๋จ๋ณ์ด ์๋ ๊ฐ์๊ฒ๋ ์ ์ฉํ์ง ์์ ๊ฒ์ผ๋ก ๋ณด์ ๋๋ค. ๋ณด์ถฉ์ ์๋ ์๋ฌผํ์ ํ์ฑ์ ๊ฐ์ง 3๊ฐ ํฌ๋ก๋ฎด(Cr III)์ด ์ฌ์ฉ๋ฉ๋๋ค.
์์ฉ ๊ธฐ์ : Chromium is an active component of the **glucose tolerance factor (GTF)**, a complex of molecules including glycine, glutamic acid, cysteine, and nicotinic acid. While its exact role in carbohydrate and nitrogen metabolism is not fully elucidated, it is thought to enhance **insulin receptor** sensitivity and facilitate glucose transport into cells. * **GTF โ Insulin Receptor Binding โ Enhanced Intracellular Glucose Uptake** * It does *not* lower blood glucose levels in normal, healthy patients.
๋๋ฌผ ์ข ๋ณ ์ฉ๋
- For use as an oral hypoglycemic agent ยท Chromium picolinate 200 micrograms (per cat) PO once a day. ยท PO ยท q24h
- For adjunctive treatment of feline obesity ยท Chromium picolinate 20 micrograms/kg PO every other a day ยท PO ยท q48h
์ฉ๋์ ๋ฉดํ ์์ ์ ๋ฌธ๊ฐ๋ฅผ ์ํ ์์ ์ฐธ๊ณ ์๋ฃ์ ๋๋ค. ํญ์ ์ต์ ๋ผ๋ฒจ๊ณผ ๊ฐ๋ณ ํ์์ ๋ํด ํ์ธํ์ญ์์ค.
ํฌ์ฌ ๊ฒฝ๋ก
๊ธ๊ธฐ
- Renal insufficiency (use with caution)
์ด์๋ฐ์
- Cognitive, perceptual, and motor dysfunction (reported in humans receiving the picolinate salt)
์ฝ๋ฌผ ์ํธ์์ฉ
- Corticosteroids ยท May increase the urinary excretion of chromium
- H2 Blockers (cimetidine, ranitidine, famotidine) or Proton Pump Inhibitors (omeprazole) ยท May decrease chromium levels by inhibiting their absorption; clinical significance is unclear
- NSAIDs ยท May increase the absorption and retention of chromium; clinical significance is unlikely
- Zinc ยท Theoretically, co-administration of zinc with chromium could decrease the oral absorption of both
๋ชจ๋ํฐ๋ง
- Fasting blood glucose
- Appetite and attitude
- Body condition and weight
- PU/PD resolution
- Serum fructosamine levels
- Glycosylated hemoglobin levels
๊ณผ์ฉ๋
Little information on acute overdoses is available. In humans, there are case reports of women developing renal failure after taking excessive doses of chromium picolinate.
VetSheet ์ฝ๋ฌผ ๋ ํผ๋ฐ์ค๋ ๋ฉดํ ์์ ์ ๋ฌธ๊ฐ๋ฅผ ์ํ ์์ ์์ฌ๊ฒฐ์ ๋ณด์กฐ ๋๊ตฌ์ด๋ฉฐ, ์ ๋ฌธ์ ํ๋จ์ด๋ ์ ์กฐ์ฌ์ ์ต์ ๋ผ๋ฒจ์ ๋์ ํ์ง ์์ต๋๋ค.