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동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• No specific contraindications available, but use with caution in patients with known hypersensitivity.

이상반응

• Thrombocytopenia (reported in dogs)
• Transient and self-resolving slight swelling of mammary glands (female dogs)
• Hepatotoxicity (rare, reported in humans)
• Nephrotoxicity (rare, reported in humans)
• Headache (humans)
• Decreased libido (humans)

약물 상호작용

• Propranolol · Increases plasma levels of beta-blockers due to CYP450 inhibition · moderate
• Verapamil · Increases plasma levels of calcium-channel blockers · moderate
• Diazepam · Increases plasma levels of diazepam · moderate
• Lidocaine · Increases plasma levels of lidocaine · major
• Metronidazole · Increases plasma levels of metronidazole · moderate
• Pethidine · Increases plasma levels of pethidine · moderate
• Theophylline · Increases plasma levels of theophylline · major
• Myelosuppressive agents · May exacerbate leucopenia · moderate
• Sucralfate · May decrease cimetidine bioavailability; administer sucralfate at least 2 hours before · minor
• Antacids · May decrease absorption; stagger oral doses by 2 hours · minor
• Digoxin · Altered absorption/metabolism; stagger oral doses by 2 hours · moderate
• Itraconazole · Decreased absorption of itraconazole due to reduced gastric acidity; stagger oral doses by 2 hours · moderate
• Maropitant · Potential interaction; stagger oral doses by 2 hours · minor

모니터링

• Clinical signs of GI ulceration or bleeding
• Renal function (to guide dose reduction if impaired)
• Heart rate and blood pressure (if administering IV)
• Complete blood count (monitor for thrombocytopenia or leucopenia, especially if on concurrent myelosuppressive drugs)

과용량

Adverse reactions are generally minor even at high doses. Supportive care should be provided if massive overdose occurs.