시미콕시브

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Dogs less than 10 weeks of age
• Dogs weighing less than 2 kg
• Gastrointestinal disorders or ulceration
• Impaired hepatic, cardiac, or renal function
• Bleeding disorders
• Pregnancy and lactation
• Hypersensitivity to NSAIDs or sulfonamides

이상반응

• Vomiting
• Diarrhea
• Anorexia
• Gastrointestinal ulceration
• Elevated liver enzymes
• Renal impairment
• Lethargy

약물 상호작용

• Corticosteroids · Increased risk of severe gastrointestinal ulceration and bleeding · major
• Other NSAIDs · Increased risk of gastrointestinal and renal toxicity · major
• ACE inhibitors · Increased risk of nephrotoxicity and reduced hypotensive effect · moderate
• Diuretics · Increased risk of nephrotoxicity · moderate
• Warfarin · Competition for plasma protein binding sites, potentially increasing bleeding risk · moderate

모니터링

• Renal function (BUN, Creatinine, SDMA, Urinalysis)
• Hepatic function (ALT, ALP, Bilirubin)
• Clinical signs of GI upset (vomiting, diarrhea, melena)
• Hydration status

과용량

Overdose may lead to severe gastrointestinal signs (vomiting, bloody diarrhea, ulceration), renal failure, and hepatic damage. > **Treatment:** Discontinue the drug immediately. Initiate supportive care including intravenous fluid therapy to support renal perfusion, gastroprotectants (e.g., omeprazole, sucralfate), and closely monitor renal and hepatic blood parameters.