μ μ½ν λ° νλ λλμλ‘
**μ μ½ν**(μ΄κΈ° λΉμ€ν λ‘μ΄λμ± νμΌμ¦μ )κ³Ό **νλ λλμλ‘ **(κΈλ£¨μ½μ½λ₯΄ν°μ½μ΄λ)μ 볡ν©μ μ λλ€. μμ¬μ μΌλ‘ λ°λ €κ²¬μ 골κ΄μ μΌ λ° μΌμ¦μ± μ§ν κ΄λ¦¬μ μ¬μ©λμμ΅λλ€. > **μμ ν:** νλ μμνμμλ NSAIDμ μ½λ₯΄ν°μ½μ€ν λ‘μ΄λλ₯Ό λ³μ©νλ κ²μ΄ μ¬κ°ν μμ₯κ΄ κΆ€μ λ° μ²κ³΅μ μνμ ν¬κ² μ¦κ°μν€λ―λ‘ μΌλ°μ μΌλ‘ κΈκΈ°μλ©λλ€. μ΄λ κΈ°μ‘΄ μ ν(μ: PLT μ μ )μ΄λ©°, νΉν μ μ½νκ³Ό κ΄λ ¨λ κ°λ μ±μ λν λ§€μ° μ£Όμ κΉμ λͺ¨λν°λ§μ΄ νμν©λλ€.
μμ© κΈ°μ : **Cinchophen** acts as an NSAID by inhibiting **cyclooxygenase (COX)** enzymes β decreased synthesis of pro-inflammatory prostaglandins. **Prednisolone** is a synthetic glucocorticoid that binds to cytosolic receptors β alters gene transcription β inhibits **phospholipase A2** via lipocortin β decreases arachidonic acid release and reduces inflammatory cytokines.
ν¬μ¬ κ²½λ‘
κΈκΈ°
- Pre-existing gastrointestinal ulceration
- Hepatic impairment
- Renal impairment
- Concurrent use of other NSAIDs or corticosteroids
μ΄μλ°μ
- Gastrointestinal ulceration
- Hepatotoxicity
- Polyuria (PU)
- Polydipsia (PD)
- Polyphagia
- Vomiting
- Diarrhea
- Melena
μ½λ¬Ό μνΈμμ©
- NSAIDs (other) Β· Increased risk of severe GI ulceration and perforation Β· major
- Corticosteroids (other) Β· Increased risk of severe GI ulceration and immunosuppression Β· major
- Other NSAIDs (e.g., Meloxicam, Carprofen) Β· Synergistic toxicity leading to severe gastrointestinal ulceration and perforation. Β· major
- Other Corticosteroids (e.g., Dexamethasone) Β· Synergistic toxicity leading to severe gastrointestinal ulceration and perforation. Β· major
- Furosemide Β· Increased risk of nephrotoxicity and gastrointestinal ulceration. Β· moderate
λͺ¨λν°λ§
- Clinical signs of GI ulceration (vomiting, melena, anorexia)
- Liver function tests (ALT, ALP, AST, Bilirubin)
- Renal parameters (BUN, Creatinine)
κ³Όμ©λ
Overdosage significantly increases the risk of **gastrointestinal perforation**, severe **hepatotoxicity**, and acute renal failure. Treatment is supportive, including GI protectants (e.g., omeprazole, sucralfate), intravenous fluid therapy, and hepatoprotectants.
VetSheet μ½λ¬Ό λ νΌλ°μ€λ λ©΄ν μμ μ λ¬Έκ°λ₯Ό μν μμ μμ¬κ²°μ 보쑰 λꡬμ΄λ©°, μ λ¬Έμ νλ¨μ΄λ μ μ‘°μ¬μ μ΅μ λΌλ²¨μ λμ νμ§ μμ΅λλ€.