신코펜 및 프레드니솔론

투여 경로

금기

• Pre-existing gastrointestinal ulceration
• Hepatic impairment
• Renal impairment
• Concurrent use of other NSAIDs or corticosteroids

이상반응

• Gastrointestinal ulceration
• Hepatotoxicity
• Polyuria (PU)
• Polydipsia (PD)
• Polyphagia
• Vomiting
• Diarrhea
• Melena

약물 상호작용

• NSAIDs (other) · Increased risk of severe GI ulceration and perforation · major
• Corticosteroids (other) · Increased risk of severe GI ulceration and immunosuppression · major
• Other NSAIDs (e.g., Meloxicam, Carprofen) · Synergistic toxicity leading to severe gastrointestinal ulceration and perforation. · major
• Other Corticosteroids (e.g., Dexamethasone) · Synergistic toxicity leading to severe gastrointestinal ulceration and perforation. · major
• Furosemide · Increased risk of nephrotoxicity and gastrointestinal ulceration. · moderate

모니터링

• Clinical signs of GI ulceration (vomiting, melena, anorexia)
• Liver function tests (ALT, ALP, AST, Bilirubin)
• Renal parameters (BUN, Creatinine)

과용량

Overdosage significantly increases the risk of **gastrointestinal perforation**, severe **hepatotoxicity**, and acute renal failure. Treatment is supportive, including GI protectants (e.g., omeprazole, sucralfate), intravenous fluid therapy, and hepatoprotectants.