클레마스틴

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Known hypersensitivity to clemastine

이상반응

• Sedation (dogs)
• Paradoxical hyperactivity (dogs)
• Anticholinergic effects: dry mucous membranes, tachycardia, urinary retention
• Diarrhea (cats)
• Fixed drug reaction (cats - rare)

약물 상호작용

• CNS Depressant Medications (e.g., barbiturates, tranquilizers) · Additive CNS depression may occur.
• Monoamine Oxidase Inhibitors (e.g., furazolidone, amitraz, selegiline) · May intensify the anticholinergic effects of clemastine.
• CNS Depressants (e.g., phenobarbital, gabapentin, opioids) · Additive CNS depression and sedation · moderate
• Anticholinergic drugs · Additive anticholinergic effects (dry mouth, urinary retention) · moderate

모니터링

• Clinical efficacy (reduction in pruritus, allergic signs)
• Adverse effects (sedation, hyperactivity, anticholinergic signs)

과용량

There are no specific antidotes for clemastine overdose. * **Management:** Handle significant overdoses using standard gut-emptying protocols (emesis/gastric lavage) when appropriate, followed by supportive therapy. * **Clinical Signs:** Overdose signs are extensions of the drug's side effects, principally **CNS depression** (though CNS stimulation/seizures may occur), severe **anticholinergic effects** (severe drying of mucous membranes, tachycardia, urinary retention, hyperthermia), and possibly hypotension. * **Specific Treatments:** **Physostigmine** may be considered to treat serious CNS anticholinergic effects. **Diazepam** can be employed to treat seizures if necessary.