클렌부테롤

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Food-producing animals (strictly banned by law)
• Horses suspected of having cardiovascular impairment
• Pregnant mares near full-term (unless used specifically for dystocia management)

이상반응

• Muscle tremors
• Sweating
• Restlessness
• Urticaria
• Tachycardia
• Creatine kinase (CK) elevations
• Ataxia (rare)
• Abortion in pregnant animals
• Cardiac hypertrophy and collagen infiltration (with chronic use)

약물 상호작용

• Inhalant Anesthetics (halothane, isoflurane, methoxyflurane) · May predispose the patient to ventricular arrhythmias, particularly with preexisting cardiac disease.
• Beta-Blockers (e.g., propranolol) · May antagonize clenbuterol's bronchodilating and tocolytic effects.
• Digoxin · May increase the risk of cardiac arrhythmias.
• Dinoprost (Prostaglandin F2alpha) · Clenbuterol may antagonize the ecbolic effects of dinoprost.
• Oxytocin · Clenbuterol may antagonize the uterine contracting effects of oxytocin.
• Other Sympathomimetic Amines (terbutaline, albuterol) · Concomitant administration may enhance the adverse cardiovascular and neurologic effects of clenbuterol.
• Tricyclic Antidepressants or MAOIs · May potentiate the vascular effects of clenbuterol.

모니터링

• Clinical efficacy (improvement in respiratory rate, effort, and reduction of cough)
• Heart rate and rhythm (monitor for tachycardia or arrhythmias)
• Signs of muscle tremors, sweating, or restlessness
• Creatine kinase (CK) levels if myopathy is suspected

과용량

Overdoses can cause severe sympathomimetic toxicity (extreme tachycardia, arrhythmias, severe muscle tremors, hypertension followed by hypotension, and hypokalemia). **Treatment**: * **Decontamination**: Emptying the gut (gastric lavage/activated charcoal) may be appropriate depending on the dosage and timing of ingestion. * **Medical Management**: Provide supportive therapy. Administration of parenteral **beta-blockers** (e.g., propranolol, esmolol) may be considered to control heart rate, rhythm, and elevated blood pressure.