클로프로스테놀 나트륨

프로스타글란딘 (F-클래스 유사체)

클로프로스테놀 나트륨은 강력한 **황체 분해** 특성으로 수의학에서 널리 사용되는 합성 **프로스타글란딘 F2α(PGF2α) 유사체**입니다. 천연 디노프로스트와 구조적으로 유사하지만 훨씬 더 강력하고 작용 시간이 깁니다. * **대동물:** 소, 말, 돼지의 번식 관리에서 발정 동기화, 분만 유도, 황체 낭종, 미라화 태아 또는 만성 자궁내막염과 같은 생식기 병리 관리에 필수적으로 사용됩니다. * **소동물:** 개에서는 임신 중절 및 개방형 자궁축농증의 내과적 치료를 위해 허가 외(off-label)로 사용됩니다. **임상 요점:** 합성 유사체이기 때문에 말에서는 천연 PGF2α(디노프로스트)에 비해 전신 부작용이 적게 나타나는 경우가 많지만, 개에서는 여전히 심각한 콜린성 부작용(아트로핀과 같은 항콜린제 전처치로 완화 가능)이 발생할 수 있습니다.

작용 기전: Cloprostenol acts as a potent agonist at **prostaglandin F (FP) receptors**. * **Luteolysis:** Binds to FP receptors on the **corpus luteum (CL)** → induces rapid functional and structural regression (luteolysis) → sharp decline in **progesterone** production. This drop in progesterone removes the negative feedback on the hypothalamus/pituitary, allowing a return to estrus, or induces abortion/parturition depending on the stage of gestation. * **Myometrial Contraction:** Directly stimulates FP receptors on **uterine smooth muscle** → increases intracellular calcium → powerful, rhythmic uterine contractions (ecbolic effect). * **Cervical Relaxation:** Concurrently promotes relaxation and dilation of the cervix, facilitating the expulsion of uterine contents (e.g., fetus, purulent material in pyometra).

동물 종별 용량

Goats

To induce parturition in does · 62.5-125 micrograms · IM · once · Give at 144 days of gestation in early morning. Deliveries will peak at 30-35 hours after injection. Maintain goat in usual surroundings and minimize outside disturbances.
To treat pseudopregnancy (hydrometra/mucometra) · 125 micrograms · IM · once

Cattle

For treatment of pyometra · 500 micrograms · IM · once · Up to 97% efficacy.
For pyometra or chronic endometritis, mummified fetus, luteal cysts · 500 micrograms · IM · once · Manual assistance may be required to remove mummified fetus from vagina.
For unobserved or undetected estrus in cows with continued ovarian cyclicity and a mature corpus luteum · 500 micrograms · IM · once · Estrus should commence in 2-5 days at which time the animal may be inseminated. If estrus detection is not possible, inseminate twice at 72 and 96 hours post injection.
For abortion, from one week after mating to approximately the 150th day of gestation · 500 micrograms · IM · once · Abortion generally takes place in 4-5 days after injection.
For controlled breeding (Single injection method) · 500 micrograms · IM · once · Use only animals with mature corpus luteum. Inseminate at usual time after detecting estrus, or once at 72 hours, or twice at 72 and 96 hours post injection.
For controlled breeding (Double injection method) · 500 micrograms · IM · Repeat dose 11 days later · Estrus should occur in 2-5 days after second injection.

투여 경로

IMSC

금기

Pregnancy (when abortion or induced parturition are not desired)
Intravenous (IV) administration

이상반응

Increased salivation (dogs)
Tachycardia (dogs)
Increased urination and defecation (dogs)
Gagging and vomiting (dogs)
Ataxia and mild depression (dogs)
Sweating (horses)
Cramping and loose stools (horses)
Increased risk of dystocia if used after 5th month of gestation (cattle)

약물 상호작용

Oxytocic agents · Activity may be enhanced by cloprostenol

모니터링

Resolution of clinical signs (e.g., clearance of pyometra)
Estrus behavior and timing
Confirmation of pregnancy termination/abortion
Adverse cholinergic effects in dogs (salivation, vomiting, heart rate)

과용량

In **cattle**, doses of 50 and 100 times those recommended may cause signs of uneasiness, slight frothing, and milk let-down. In **small animals**, overdoses of cloprostenol or other synthetic prostaglandin F2α analogs reportedly can result in severe shock and death.

VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.