클로프로스테놀 나트륨
Cloprostenol Sodium
Cloprostenol sodium
다른 이름: Estrumate · estroPLAN · ICI-80996
VetSheet 수의사 팀 검수업데이트 2026년 4월 5일근거 기반 수의학 참고자료
용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.
동물 종별 용량
🌎 NA — North America🌍 EU — Europe
개
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Adjunctive treatment of open cervix pyometra | 1-5 micrograms/kg (0.001-0.005 mg/kg) | Not specified | once per day | Up to 2-3 weeks | 🌎 NA |
| Adjunctive treatment of open cervix pyometra | 1 microgram/kg | SC | every 5 days | for 15 days (if not cured earlier) | 🌎 NA |
| Pregnancy termination | 1-2.5 micrograms/kg | SC | once daily | for 4-7 days | 🌎 NA |
| Pregnancy termination | 1-2.5 micrograms/kg | SC | every 48 hours | for three doses | 🌎 NA |
- Adjunctive treatment of open cervix pyometra: When starting treatment, start with one-half the normal dosage and gradually achieve the full dose within 2-3 days.
- Adjunctive treatment of open cervix pyometra: Give not during feeding. Use with aglepristone at 10 mg/kg SC every 5 days until cured. Give Clavamox (12.5 mg/kg PO twice daily) and supportive hydration throughout protocol.
- Pregnancy termination: Successful in terminating pregnancy in dogs after 30 days gestation.
- Pregnancy termination: At higher dose (2.5 mg/kg); appears very effective starting at 30 days of pregnancy. Anticholinergic drug administration (e.g., atropine) 15 minutes prior to dosing appears to lessen adverse effects.
말
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| To cause abortion prior to the twelfth day of gestation | 100 micrograms | IM | once | — | 🌎 NA |
| For luteolysis and to stimulate uterine contractions | 250 micrograms (total dose) | IM | once | — | 🌎 NA |
| For luteolysis | 25-250 micrograms (0.1-1 mL) | IM | once | — | 🌎 NA |
| As an ecbolic | 250 micrograms (1 mL) | IM | q24h | — | 🌎 NA |
- To cause abortion prior to the twelfth day of gestation: Most effective day 7 or 8 post estrus. Mare will usually return to estrus within 5 days.
- For luteolysis and to stimulate uterine contractions: Research has shown that 1/10th of a dose can still cause luteolysis and if given on once or on two consecutive days can avoid side effects.
- For luteolysis: Should not be used more than one day after ovulation because it can damage the corpus luteum and reduce progesterone.
소
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| For treatment of pyometra | 500 micrograms | IM | once | — | 🌎 NA |
| For pyometra or chronic endometritis, mummified fetus, luteal cysts | 500 micrograms | IM | once | — | 🌎 NA |
| For unobserved or undetected estrus in cows with continued ovarian cyclicity and a mature corpus luteum | 500 micrograms | IM | once | — | 🌎 NA |
| For abortion, from one week after mating to approximately the 150th day of gestation | 500 micrograms | IM | once | — | 🌎 NA |
| For controlled breeding (Single injection method) | 500 micrograms | IM | once | — | 🌎 NA |
| For controlled breeding (Double injection method) | 500 micrograms | IM | Repeat dose 11 days later | — | 🌎 NA |
- For treatment of pyometra: Up to 97% efficacy.
- For pyometra or chronic endometritis, mummified fetus, luteal cysts: Manual assistance may be required to remove mummified fetus from vagina.
- For unobserved or undetected estrus in cows with continued ovarian cyclicity and a mature corpus luteum: Estrus should commence in 2-5 days at which time the animal may be inseminated. If estrus detection is not possible, inseminate twice at 72 and 96 hours post injection.
- For abortion, from one week after mating to approximately the 150th day of gestation: Abortion generally takes place in 4-5 days after injection.
- For controlled breeding (Single injection method): Use only animals with mature corpus luteum. Inseminate at usual time after detecting estrus, or once at 72 hours, or twice at 72 and 96 hours post injection.
- For controlled breeding (Double injection method): Estrus should occur in 2-5 days after second injection.
돼지
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| To induce parturition in sows | 175 micrograms | IM | once | — | 🌎 NA |
- To induce parturition in sows: Give 2 days or less before anticipated date of farrowing. Farrowing generally occurs in approximately 36 hours after injection.
염소
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| To induce parturition in does | 62.5-125 micrograms | IM | once | — | 🌎 NA |
| To treat pseudopregnancy (hydrometra/mucometra) | 125 micrograms | IM | once | — | 🌎 NA |
- To induce parturition in does: Give at 144 days of gestation in early morning. Deliveries will peak at 30-35 hours after injection. Maintain goat in usual surroundings and minimize outside disturbances.
용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.
개요
클로프로스테놀 나트륨은 강력한 황체 분해 특성으로 수의학에서 널리 사용되는 합성 프로스타글란딘 F2α(PGF2α) 유사체입니다. 천연 디노프로스트와 구조적으로 유사하지만 훨씬 더 강력하고 작용 시간이 깁니다.
- 대동물: 소, 말, 돼지의 번식 관리에서 발정 동기화, 분만 유도, 황체 낭종, 미라화 태아 또는 만성 자궁내막염과 같은 생식기 병리 관리에 필수적으로 사용됩니다.
- 소동물: 개에서는 임신 중절 및 개방형 자궁축농증의 내과적 치료를 위해 허가 외(off-label)로 사용됩니다.
임상 요점: 합성 유사체이기 때문에 말에서는 천연 PGF2α(디노프로스트)에 비해 전신 부작용이 적게 나타나는 경우가 많지만, 개에서는 여전히 심각한 콜린성 부작용(아트로핀과 같은 항콜린제 전처치로 완화 가능)이 발생할 수 있습니다.
작용 기전
Cloprostenol acts as a potent agonist at prostaglandin F (FP) receptors.
- Luteolysis: Binds to FP receptors on the corpus luteum (CL) → induces rapid functional and structural regression (luteolysis) → sharp decline in progesterone production. This drop in progesterone removes the negative feedback on the hypothalamus/pituitary, allowing a return to estrus, or induces abortion/parturition depending on the stage of gestation.
- Myometrial Contraction: Directly stimulates FP receptors on uterine smooth muscle → increases intracellular calcium → powerful, rhythmic uterine contractions (ecbolic effect).
- Cervical Relaxation: Concurrently promotes relaxation and dilation of the cervix, facilitating the expulsion of uterine contents (e.g., fetus, purulent material in pyometra).
안전성·주의사항
금기사항
- Pregnancy (when abortion or induced parturition are not desired)
- Intravenous (IV) administration
부작용
- Increased salivation (dogs)
- Tachycardia (dogs)
- Increased urination and defecation (dogs)
- Gagging and vomiting (dogs)
- Ataxia and mild depression (dogs)
- Sweating (horses)
- Cramping and loose stools (horses)
- Increased risk of dystocia if used after 5th month of gestation (cattle)
주의
Women of child-bearing age, pregnant women, and persons with asthma or other respiratory diseases should use extreme caution when handling cloprostenol, as the drug may induce abortion or acute bronchoconstriction. Cloprostenol is readily absorbed through the skin and must be washed off immediately with soap and water. Do not administer IV.
약물 상호작용
Activity may be enhanced by cloprostenol
모니터링
- Resolution of clinical signs (e.g., clearance of pyometra)
- Estrus behavior and timing
- Confirmation of pregnancy termination/abortion
- Adverse cholinergic effects in dogs (salivation, vomiting, heart rate)
약동학
흡수
Readily absorbed through the skin.
과다투여
In cattle, doses of 50 and 100 times those recommended may cause signs of uneasiness, slight frothing, and milk let-down.
In small animals, overdoses of cloprostenol or other synthetic prostaglandin F2α analogs reportedly can result in severe shock and death.
제품
제형
- Injection (250 micrograms/mL)
동물용의약품
- Cloprostenol Sodium Injection equivalent to 250 micrograms/mL cloprostenol in 20 mL vials (Estrumate, estroPLAN)
인용의약품
- None
규제 현황
규제 데이터 없음: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
보관·안정성
Store at room temperature (15-30°C); protect from light.
보호자 정보
중대한 인체 안전 경고: 클로프로스테놀은 피부를 통해 쉽게 흡수되며 사람에게 심각한 부작용을 일으킬 수 있습니다.
- 임산부, 가임기 여성, 천식 환자 및 기관지 질환이 있는 사람은 이 제품을 취급할 때 극도로 주의하거나 취급을 완전히 피해야 합니다. 우발적인 노출은 유산이나 급성 기관지 경련(천식 발작)을 유발할 수 있습니다.
- 피부에 우발적으로 노출된 경우 즉시 비누와 물로 씻어내십시오.
- 이 약물은 사용법과 안전 예방 조치를 완전히 숙지한 사람만 취급하고 투여해야 합니다.
- 개에서는 투여 직후 침 흘림, 구토, 배뇨/배변 증가 또는 헐떡임과 같은 부작용이 나타날 수 있습니다. 수의사는 이러한 영향을 최소화하기 위해 추가 약물을 처방할 수 있습니다.
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