콜히친

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Serious renal dysfunction
• Serious gastrointestinal dysfunction
• Serious cardiac dysfunction
• Pregnancy (unless benefits strictly outweigh risks)
• Pregnancy
• Severe renal impairment

이상반응

• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Anorexia
• Bone marrow suppression (with prolonged use)
• Neutropenia (rare)
• Severe local irritation/thrombophlebitis (if extravasated IV)
• Diarrhoea
• Renal damage (rare)
• Bone marrow suppression (rare)
• Myopathy (rare)
• Peripheral neuropathy (rare)
• Increased serum ALP
• Decreased platelet counts

약물 상호작용

• Bone Marrow Depressants (e.g., antineoplastics, immunosuppressants, chloramphenicol, amphotericin B) · May cause additive myelosuppression when used concurrently with colchicine.
• Ciclosporin · Possible increased risk of nephrotoxicity and myotoxicity · major
• NSAIDs (e.g., Phenylbutazone) · May increase the risks of thrombocytopenia, leucopenia, or bone marrow depression · major
• Anticancer chemotherapeutics · May cause additive myelosuppressive effects · major

모니터링

• Clinical efficacy
• Adverse effects (especially GI signs as early indicators of toxicity)
• CBC (to monitor for bone marrow suppression)
• Gastrointestinal signs (vomiting, diarrhea)
• Complete Blood Count (platelets, WBCs)
• Liver enzymes (ALP)
• Renal function parameters
• Urinalysis

과용량

### Toxicity Profile Colchicine has a **narrow therapeutic index** and can be highly toxic even after relatively small overdoses. In humans, ingestion of as little as 7 mg has been fatal, with 65 mg considered a lethal dose in adults. ### Clinical Signs of Overdose - **Early Signs:** Severe gastrointestinal distress (anorexia, vomiting, bloody diarrhea, paralytic ileus). - **Advanced Signs:** Renal failure, hepatotoxicity, pancytopenia, ascending paralysis, shock, and vascular collapse. ### Management - **No specific antidote exists.** - **Decontamination:** Gut removal techniques should be employed when applicable. Due to extensive **enterohepatic recycling**, administering **repeated doses of activated charcoal** along with a saline cathartic is highly recommended to interrupt systemic reabsorption. - **Supportive Care:** Aggressive fluid therapy, symptomatic management, and potentially peritoneal dialysis.