코르티손 아세테이트

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Hypersensitivity to cortisone acetate
• Systemic fungal infections (general corticosteroid contraindication)

이상반응

• Vomiting
• Inappetence
• Diarrhea
• Hypersensitivity reactions (rare)
• Polyuria/Polydipsia/Polyphagia (at supra-physiologic doses)
• Panting (at supra-physiologic doses)
• Immunosuppression (at supra-physiologic doses)

약물 상호작용

• Amphotericin B · Concomitant use may cause hypokalemia; risk of CHF and cardiac enlargement reported in humans.
• Aspirin · Glucocorticoids may reduce salicylate blood levels and increase risk for GI ulceration/bleeding.
• Diuretics, Potassium-Depleting (e.g., furosemide, thiazides) · Concomitant administration may cause hypokalemia.
• Estrogens · May potentiate the effects of hydrocortisone/glucocorticoids.
• Insulin and Antidiabetic Agents · Insulin requirements may increase due to glucocorticoid-induced insulin resistance.
• Mitotane · May alter steroid metabolism; higher doses of steroids may be needed to treat mitotane-induced adrenal insufficiency.
• NSAIDs · Increased risk of gastrointestinal ulceration and bleeding.
• Vaccines (Live attenuated) · Virus replication may be augmented if given at immunosuppressive doses; diminished immune response to killed vaccines/toxoids.
• Warfarin · May affect INR values; requires monitoring.

모니터링

• Weight, appetite, signs of edema
• Serum and/or urine electrolytes (Na+, K+)
• Total plasma proteins, albumin
• Blood glucose
• Growth and development in young animals
• ACTH stimulation test (Note: Cortisone cross-reacts with cortisol assays; must test before administration)

과용량

Acute ingestion is rarely a clinical problem, and severe clinical effects are unlikely with a single acute overdose. However, neuropsychiatric effects can occur. Cardiac arrhythmias and anaphylaxis are theoretically possible but very rare. Treatment is generally supportive.