COP 항암화학요법 프로토콜

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Severe neutropenia (< 2 x 10^9/L)
• Pre-existing haemorrhagic cystitis
• Known MDR1 mutation (requires extreme caution/dose adjustment for vincristine)

이상반응

• Myelosuppression (neutropenia)
• Haemorrhagic cystitis (cyclophosphamide)
• Gastrointestinal toxicity (vomiting, diarrhoea, anorexia)
• Tissue necrosis if extravasated (vincristine)

약물 상호작용

• Cimetidine · Inhibits hepatic cytochrome P450 enzyme pathway, potentially altering the metabolism and increasing toxicity of chemotherapeutics. · major

모니터링

• Haematology (prior to each vincristine treatment)
• Biochemistry (prior to first treatment, then minimum every 6 months)
• Free-catch urine dipstick (prior to each cyclophosphamide administration to check for blood)
• Urine culture (if blood is noted on dipstick)

과용량

**Severe toxicity:** Overdose of these chemotherapeutics can lead to fatal myelosuppression, severe gastrointestinal sloughing, sepsis, and death. Extravasation of vincristine causes severe, progressive tissue necrosis requiring immediate management (e.g., hyaluronidase, warm compresses).