닥티노마이신

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Hypersensitivity to dactinomycin
• Pregnancy (teratogenic and embryotoxic)

이상반응

• Bone marrow depression (anemia, leukopenia, thrombocytopenia)
• Gastrointestinal toxicity (diarrhea, ulcerative stomatitis, GI ulceration)
• Severe tissue damage and pain (if extravasated)
• Hyperuricemia (may require allopurinol)
• Hepatotoxicity

약물 상호작용

• Doxorubicin · Additive cardiotoxicity may occur if used concurrently or sequentially. · major
• Myelosuppressive drugs (e.g., chloramphenicol, flucytosine, colchicine, other antineoplastics) · May cause additive myelosuppression.
• Vitamin K · Patients may require higher dosages of vitamin K when receiving dactinomycin.

모니터링

• Efficacy (tumor measurement/response)
• Complete Blood Count (CBC) with differential and platelets (prior to each dose and at nadir)
• Hepatic function tests
• Oral cavity examinations (check for ulcerative stomatitis)
• IV catheter site for any signs of extravasation during administration

과용량

Due to the extreme toxic potential of this agent, iatrogenic overdoses must be strictly avoided. Double-check all dosage calculations (ensure dosing is in **mg/m2**, not mg/kg). Overdose will result in severe, potentially fatal bone marrow suppression and gastrointestinal ulceration. Treatment is entirely symptomatic and supportive (e.g., broad-spectrum antibiotics, blood transfusions, aggressive fluid therapy, GI protectants).