다나졸

안드로겐 / 면역조절제

다나졸은 **합성 안드로겐**입니다. 수의학에서는 주로 개와 고양이의 **면역매개성 용혈성 빈혈(IMHA)** 및 **면역매개성 혈소판 감소증(ITP)** 치료를 위한 보조 면역조절제로 사용됩니다. 효능을 예측하기 어렵고 작용이 느리기 때문에 일반적으로 글루코코르티코이드와 같은 표준 요법에 불응성인 환자에게 구제 요법으로 사용됩니다.

작용 기전: Danazol possesses weak androgenic, anabolic, and antiestrogenic properties. Its immunomodulatory effects are achieved through several mechanisms: * **Fc Receptor Modulation**: Reduces the affinity of autoantibodies for the **mononuclear phagocytic system Fc receptors** → decreases the macrophage-mediated destruction of antibody-coated red blood cells and platelets. * **Steroid-Binding Globulin Competition**: Competes with glucocorticoids for binding sites on **corticosteroid-binding globulin (CBG)** → increases the fraction of free, pharmacologically active glucocorticoids in circulation, enhancing their efficacy. * **Pituitary-Ovarian Axis Suppression**: Inhibits the synthesis of sex steroids and binds directly to sex steroid receptors in target tissues.

동물 종별 용량

Cats

Adjunctive treatment of immune-mediated hemolytic anemia · 5 mg/kg PO twice daily · PO · q12h

Dogs

Adjunctive treatment of immune-mediated hemolytic anemia (non-regenerative forms) · 5 mg/kg PO three times daily. · PO · q8h · Used to reduce the dose of glucocorticoids needed for long-term therapy.
Adjunctive treatment of immune-mediated hemolytic anemia or thrombocytopenia · 5 mg/kg PO 2-3 times per day · PO · q8-12h · Rarely helpful. Costly and has limited effectiveness.
Adjunctive treatment of immune-mediated hemolytic anemia or thrombocytopenia · 10 mg/kg/day PO. Once anemia improves, corticosteroids may be slowly tapered and eventually DC'd. When remission maintained by danazol alone, may lower to 5 mg/kg/day. Slowly taper after 2-3 months of normal hemograms with frequent monitoring of hemograms. · PO · q24h · Long-term · Initially given in addition to prednis(ol)one.

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

Pregnancy (Teratogenic - FDA Category X)
Nursing/breastfeeding
Severe cardiac function impairment
Severe renal function impairment
Severe hepatic function impairment
Undiagnosed abnormal vaginal bleeding

이상반응

Hepatotoxicity (rare but significant in dogs)
Virilization in females
Weight gain
Lethargy
Edema
Testicular atrophy
Hirsutism
Alopecia
Vaginitis (reported in humans)

약물 상호작용

Cyclosporine · May significantly increase cyclosporine levels
Insulin · By affecting carbohydrate metabolism, danazol may affect insulin requirements (doses may need to be increased) in diabetic patients
Warfarin · Concomitant use may enhance the anticoagulant effect as danazol may decrease the synthesis of procoagulant factors in the liver

모니터링

Efficacy (CBC, platelets, reticulocyte count)
Hepatic function (baseline and at regular intervals while on therapy)

과용량

No specific information was located regarding acute toxicity in animals. Significant overdoses should initially be handled by contacting an animal poison control center and initiating gut emptying protocols (emesis or gastric lavage, followed by activated charcoal) when applicable.

VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.