다노플록사신

항생제 - 플루오로퀴놀론계Critically Important

다노플록사신은 주로 육우의 소 호흡기 질병(BRD) 치료에 사용되는 수의학 전용 주사용 **플루오로퀴놀론계 항생제**입니다. *Mannheimia haemolytica* 및 *Pasteurella multocida*와 같은 주요 호흡기 병원체에 대해 농도 의존적 살균 활성을 나타냅니다. **임상 요점:** * 다른 플루오로퀴놀론계와 마찬가지로 조직 침투력이 뛰어나며, 특히 폐 조직에 대한 침투력이 우수하여 호흡기 감염에 매우 효과적입니다. * 분포 용적이 크며 삼출물 및 누출물에 잘 농축됩니다. * **규제 경고:** 미국 FDA는 식용 동물에 대한 플루오로퀴놀론계 약물의 허가 외 사용(extra-label use)을 엄격히 금지하고 있습니다.

작용 기전: Fluoroquinolones are bactericidal antibiotics that act by inhibiting bacterial DNA replication and transcription. * They enter the bacterium and inhibit **DNA gyrase** (topoisomerase II) and **topoisomerase IV**. * Inhibition of **DNA gyrase** → prevents DNA supercoiling → halts DNA replication. * Inhibition of **topoisomerase IV** → interferes with the separation of interlinked replicated DNA molecules. * This dual action leads to rapid bacterial cell death. The bactericidal activity is **concentration-dependent** rather than time-dependent.

동물 종별 용량

Cats

Ophthalmic infections · 1 drop to affected eye · topical · q6h · As directed by veterinarian · Intensive therapy: q30-120min for short-term use (1-2 days).

Cattle

Bovine Respiratory Disease (BRD) · 6 mg/kg (1.5 mL per 100 lb body weight) SC · SC · Repeat once in approximately 48 hours · 2 doses total · Administered dosage volume should not exceed 15 mL per injection site.

Dogs

Ophthalmic infections · 1 drop to affected eye · topical · q6h · As directed by veterinarian · Intensive therapy: q30-120min for short-term use (1-2 days).

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

SCIMIVTopical (Ophthalmic)

금기

Extra-label use in food-producing animals (FDA prohibited)
Lactating dairy cattle (where milk is for human consumption)
Veal calves
Animals with known or suspected CNS disorders (relative contraindication)
Known hypersensitivity to ofloxacin or other fluoroquinolones

이상반응

Hypersensitivity reactions (uncommon)
Lameness or arthropathies (especially in young animals/calves)
Local tissue reaction at the subcutaneous injection site (may result in trim loss)
Mild, transient ocular irritation or stinging upon application (general class effect)
Conjunctival hyperemia (rare)

약물 상호작용

Theophylline (aminophylline) · Potential increase in serum concentrations of theophylline; increased monitoring of theophylline concentrations is recommended

모니터링

Clinical efficacy
Injection site reactions
Signs of lameness or CNS stimulation
Clinical response to therapy (resolution of ocular discharge, inflammation, or ulceration)
Culture and sensitivity testing prior to and during prolonged treatment if no improvement

과용량

Limited information is available for cattle. High dosages (18-60 mg/kg for 3-6 days) in feeder calves can cause **arthropathies/lameness** (consistent with other fluoroquinolones), **CNS stimulation** (ataxia, nystagmus, tremors), inappetence, recumbency, depression, and exophthalmos. Some calves receiving 18 mg/kg twice 48 hours apart developed nasal pad erythema. In adult dogs, 2.4 mg/kg/day PO for 90 days resulted in no observable adverse effects.

VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.